Germline deletion of ETV6 in familial acute lymphoblastic leukemia

Recent studies have identified germline mutations in TP53, PAX5, ETV6, and IKZF1 in kindreds with familial acute lymphoblastic leukemia (ALL), but the genetic basis of ALL in many kindreds is unknown despite mutational analysis of the exome. Here, we report a germline deletion of ETV6 identified by...

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Veröffentlicht in:	Blood advances 2019-04, Vol.3 (7), p.1039-1046
Hauptverfasser:	Rampersaud, Evadnie, Ziegler, David S., Iacobucci, Ilaria, Payne-Turner, Debbie, Churchman, Michelle L., Schrader, Kasmintan A., Joseph, Vijai, Offit, Kenneth, Tucker, Katherine, Sutton, Rosemary, Warby, Meera, Chenevix-Trench, Georgia, Huntsman, David G., Tsoli, Maria, Mead, R. Scott, Qu, Chunxu, Leventaki, Vasiliki, Wu, Gang, Mullighan, Charles G.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Mutational Analysis ETS Translocation Variant 6 Protein Exome - genetics Family Genetic Predisposition to Disease Germ-Line Mutation Humans Lymphoid Neoplasia Lymphoma, Large B-Cell, Diffuse - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Proto-Oncogene Proteins c-ets - genetics Repressor Proteins - genetics Sequence Deletion Thrombocytopenia - genetics
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