Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome
22q11.2 deletion syndrome (22q11.2DS) is associated with high rates of neurodevelopmental disorder, however, the links between developmental coordination disorder (DCD), intellectual function and psychiatric disorder remain unexplored. Aims To establish the prevalence of indicative DCD in children w...
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| Veröffentlicht in: | British journal of psychiatry 2018-01, Vol.212 (1), p.27-33 |
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| creator | Cunningham, Adam C Delport, Sue Cumines, Wendy Busse, Monica Linden, David E J Hall, Jeremy Owen, Michael J van den Bree, Marianne B M |
| description | 22q11.2 deletion syndrome (22q11.2DS) is associated with high rates of neurodevelopmental disorder, however, the links between developmental coordination disorder (DCD), intellectual function and psychiatric disorder remain unexplored. Aims To establish the prevalence of indicative DCD in children with 22q11.2DS and examine associations with IQ, neurocognition and psychopathology.
Neurocognitive assessments and psychiatric interviews of 70 children with 22q11.2DS (mean age 11.2, s.d. = 2.2) and 32 control siblings (mean age 11.5, s.d. = 2.1) were carried out in their homes. Nine children with 22q11.2DS and indicative DCD were subsequently assessed in an occupational therapy clinic.
Indicative DCD was found in 57 (81.4%) children with 22q11.2DS compared with 2 (6.3%) control siblings (odds ratio (OR) = 36.7, P < 0.001). Eight of nine (89%) children with indicative DCD met DSM-5 criteria for DCD. Poorer coordination was associated with increased numbers of anxiety, (P < 0.001), attention-deficit hyperactivity disorder (ADHD) (P < 0.001) and autism-spectrum disorder (ASD) symptoms (P < 0.001) in children with 22q11.2DS. Furthermore, 100% of children with 22q11.2DS and ADHD had indicative DCD (20 of 20), as did 90% of children with anxiety disorder (17 of 19) and 96% of children who screened positive for ASD (22 of 23). The Developmental Coordination Disorder Questionnaire score was related to sustained attention (P = 0.006), even after history of epileptic fits (P = 0.006) and heart problems (P = 0.009) was taken into account.
Clinicians should be aware of the high risk of coordination difficulties in children with 22q11.2DS and its association with risk of mental disorder and specific neurocognitive deficits. Declaration of interest None. |
| doi_str_mv | 10.1192/bjp.2017.6 |
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Neurocognitive assessments and psychiatric interviews of 70 children with 22q11.2DS (mean age 11.2, s.d. = 2.2) and 32 control siblings (mean age 11.5, s.d. = 2.1) were carried out in their homes. Nine children with 22q11.2DS and indicative DCD were subsequently assessed in an occupational therapy clinic.
Indicative DCD was found in 57 (81.4%) children with 22q11.2DS compared with 2 (6.3%) control siblings (odds ratio (OR) = 36.7, P < 0.001). Eight of nine (89%) children with indicative DCD met DSM-5 criteria for DCD. Poorer coordination was associated with increased numbers of anxiety, (P < 0.001), attention-deficit hyperactivity disorder (ADHD) (P < 0.001) and autism-spectrum disorder (ASD) symptoms (P < 0.001) in children with 22q11.2DS. Furthermore, 100% of children with 22q11.2DS and ADHD had indicative DCD (20 of 20), as did 90% of children with anxiety disorder (17 of 19) and 96% of children who screened positive for ASD (22 of 23). The Developmental Coordination Disorder Questionnaire score was related to sustained attention (P = 0.006), even after history of epileptic fits (P = 0.006) and heart problems (P = 0.009) was taken into account.
Clinicians should be aware of the high risk of coordination difficulties in children with 22q11.2DS and its association with risk of mental disorder and specific neurocognitive deficits. Declaration of interest None.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.2017.6</identifier><identifier>PMID: 29433607</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Adolescent ; Age ; Anxiety disorders ; Anxiety Disorders - epidemiology ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention deficit hyperactivity disorder ; Autism ; Autism Spectrum Disorder - epidemiology ; Autistic children ; Child ; Children ; Children & youth ; Cognition ; Cognitive ability ; Comorbidity ; Coordination ; Developmental coordination disorder ; DiGeorge Syndrome - epidemiology ; Epilepsy ; Families & family life ; Female ; High risk ; Humans ; Hyperactivity ; Intellectual disabilities ; Intellectual Disability - epidemiology ; Intelligence ; Intelligence - physiology ; Intelligence tests ; Laboratories ; Male ; Mental disorders ; Motor ability ; Motor Skills Disorders - epidemiology ; Neurodevelopmental disorders ; Occupational therapy ; Population ; Premature birth ; Psychiatry ; Psychopathology ; Questionnaires ; R&D ; Research & development ; Siblings ; Sustained attention</subject><ispartof>British journal of psychiatry, 2018-01, Vol.212 (1), p.27-33</ispartof><rights>2018 This article is published under (https://creativecommons.org/licenses/by/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Authors 2018 2018 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-e0a049c09714a3ac4a83f5d8485ca43444fca1ec70f9c00dfb249634b77675963</citedby><cites>FETCH-LOGICAL-c472t-e0a049c09714a3ac4a83f5d8485ca43444fca1ec70f9c00dfb249634b77675963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,12827,27903,27904,30978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29433607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cunningham, Adam C</creatorcontrib><creatorcontrib>Delport, Sue</creatorcontrib><creatorcontrib>Cumines, Wendy</creatorcontrib><creatorcontrib>Busse, Monica</creatorcontrib><creatorcontrib>Linden, David E J</creatorcontrib><creatorcontrib>Hall, Jeremy</creatorcontrib><creatorcontrib>Owen, Michael J</creatorcontrib><creatorcontrib>van den Bree, Marianne B M</creatorcontrib><title>Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>22q11.2 deletion syndrome (22q11.2DS) is associated with high rates of neurodevelopmental disorder, however, the links between developmental coordination disorder (DCD), intellectual function and psychiatric disorder remain unexplored. Aims To establish the prevalence of indicative DCD in children with 22q11.2DS and examine associations with IQ, neurocognition and psychopathology.
Neurocognitive assessments and psychiatric interviews of 70 children with 22q11.2DS (mean age 11.2, s.d. = 2.2) and 32 control siblings (mean age 11.5, s.d. = 2.1) were carried out in their homes. Nine children with 22q11.2DS and indicative DCD were subsequently assessed in an occupational therapy clinic.
Indicative DCD was found in 57 (81.4%) children with 22q11.2DS compared with 2 (6.3%) control siblings (odds ratio (OR) = 36.7, P < 0.001). Eight of nine (89%) children with indicative DCD met DSM-5 criteria for DCD. Poorer coordination was associated with increased numbers of anxiety, (P < 0.001), attention-deficit hyperactivity disorder (ADHD) (P < 0.001) and autism-spectrum disorder (ASD) symptoms (P < 0.001) in children with 22q11.2DS. Furthermore, 100% of children with 22q11.2DS and ADHD had indicative DCD (20 of 20), as did 90% of children with anxiety disorder (17 of 19) and 96% of children who screened positive for ASD (22 of 23). The Developmental Coordination Disorder Questionnaire score was related to sustained attention (P = 0.006), even after history of epileptic fits (P = 0.006) and heart problems (P = 0.009) was taken into account.
Clinicians should be aware of the high risk of coordination difficulties in children with 22q11.2DS and its association with risk of mental disorder and specific neurocognitive deficits. Declaration of interest None.</description><subject>Adolescent</subject><subject>Age</subject><subject>Anxiety disorders</subject><subject>Anxiety Disorders - epidemiology</subject><subject>Attention Deficit Disorder with Hyperactivity - epidemiology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Autism</subject><subject>Autism Spectrum Disorder - epidemiology</subject><subject>Autistic children</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Comorbidity</subject><subject>Coordination</subject><subject>Developmental coordination disorder</subject><subject>DiGeorge Syndrome - epidemiology</subject><subject>Epilepsy</subject><subject>Families & family life</subject><subject>Female</subject><subject>High risk</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Intellectual disabilities</subject><subject>Intellectual Disability - epidemiology</subject><subject>Intelligence</subject><subject>Intelligence - physiology</subject><subject>Intelligence tests</subject><subject>Laboratories</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Motor ability</subject><subject>Motor Skills Disorders - epidemiology</subject><subject>Neurodevelopmental disorders</subject><subject>Occupational therapy</subject><subject>Population</subject><subject>Premature birth</subject><subject>Psychiatry</subject><subject>Psychopathology</subject><subject>Questionnaires</subject><subject>R&D</subject><subject>Research & development</subject><subject>Siblings</subject><subject>Sustained attention</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkV1LwzAUhoMobk5v_AFS8EbEzny1aW4EmV-DgQgK3oUsTbeONumSdrB_b-bmUK_OOZznvLyHF4BzBIcIcXw7XTRDDBEbpgegjyjDMaJpcgj6EEIWI5zAHjjxfhFGQjE7Bj3MKSEpZH3w-aBXurJNrU0rq0hZ6_LSyLa0JspLHybtbqLGr9XcNrKd28rO1pE0eTR-i0oTYbxEaIijXFf6-8ivTe5srU_BUSErr892dQA-nh7fRy_x5PV5PLqfxCoYbWMNJaRcQc4QlUQqKjNSJHlGs0RJSiilhZJIKwaLQMG8mGLKU0KnjKUsCd0A3G11m25a61yFP5ysROPKWrq1sLIUfzemnIuZXYmUJgylOAhc7QScXXbat6IuvdJVJY22nRcYQsQRTBkP6OU_dGE7Z8J7AhOSZZwzRgN1vaWUs947XezNICg2gYkQmNgEJjb2L37b36M_CZEvT9iRFA</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Cunningham, Adam C</creator><creator>Delport, Sue</creator><creator>Cumines, Wendy</creator><creator>Busse, Monica</creator><creator>Linden, David E J</creator><creator>Hall, Jeremy</creator><creator>Owen, Michael J</creator><creator>van den Bree, Marianne B M</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7TK</scope><scope>7XB</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201801</creationdate><title>Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome</title><author>Cunningham, Adam C ; Delport, Sue ; Cumines, Wendy ; Busse, Monica ; Linden, David E J ; Hall, Jeremy ; Owen, Michael J ; van den Bree, Marianne B M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-e0a049c09714a3ac4a83f5d8485ca43444fca1ec70f9c00dfb249634b77675963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Anxiety disorders</topic><topic>Anxiety Disorders - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cunningham, Adam C</au><au>Delport, Sue</au><au>Cumines, Wendy</au><au>Busse, Monica</au><au>Linden, David E J</au><au>Hall, Jeremy</au><au>Owen, Michael J</au><au>van den Bree, Marianne B M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>2018-01</date><risdate>2018</risdate><volume>212</volume><issue>1</issue><spage>27</spage><epage>33</epage><pages>27-33</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>22q11.2 deletion syndrome (22q11.2DS) is associated with high rates of neurodevelopmental disorder, however, the links between developmental coordination disorder (DCD), intellectual function and psychiatric disorder remain unexplored. Aims To establish the prevalence of indicative DCD in children with 22q11.2DS and examine associations with IQ, neurocognition and psychopathology.
Neurocognitive assessments and psychiatric interviews of 70 children with 22q11.2DS (mean age 11.2, s.d. = 2.2) and 32 control siblings (mean age 11.5, s.d. = 2.1) were carried out in their homes. Nine children with 22q11.2DS and indicative DCD were subsequently assessed in an occupational therapy clinic.
Indicative DCD was found in 57 (81.4%) children with 22q11.2DS compared with 2 (6.3%) control siblings (odds ratio (OR) = 36.7, P < 0.001). Eight of nine (89%) children with indicative DCD met DSM-5 criteria for DCD. Poorer coordination was associated with increased numbers of anxiety, (P < 0.001), attention-deficit hyperactivity disorder (ADHD) (P < 0.001) and autism-spectrum disorder (ASD) symptoms (P < 0.001) in children with 22q11.2DS. Furthermore, 100% of children with 22q11.2DS and ADHD had indicative DCD (20 of 20), as did 90% of children with anxiety disorder (17 of 19) and 96% of children who screened positive for ASD (22 of 23). The Developmental Coordination Disorder Questionnaire score was related to sustained attention (P = 0.006), even after history of epileptic fits (P = 0.006) and heart problems (P = 0.009) was taken into account.
Clinicians should be aware of the high risk of coordination difficulties in children with 22q11.2DS and its association with risk of mental disorder and specific neurocognitive deficits. Declaration of interest None.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>29433607</pmid><doi>10.1192/bjp.2017.6</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Age Anxiety disorders Anxiety Disorders - epidemiology Attention Deficit Disorder with Hyperactivity - epidemiology Attention deficit hyperactivity disorder Autism Autism Spectrum Disorder - epidemiology Autistic children Child Children Children & youth Cognition Cognitive ability Comorbidity Coordination Developmental coordination disorder DiGeorge Syndrome - epidemiology Epilepsy Families & family life Female High risk Humans Hyperactivity Intellectual disabilities Intellectual Disability - epidemiology Intelligence Intelligence - physiology Intelligence tests Laboratories Male Mental disorders Motor ability Motor Skills Disorders - epidemiology Neurodevelopmental disorders Occupational therapy Population Premature birth Psychiatry Psychopathology Questionnaires R&D Research & development Siblings Sustained attention |
| title | Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome |
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