Genome-Wide Profiling of the Toxic Effect of Bortezomib on Human Esophageal Carcinoma Epithelial Cells

Objectives: Bortezomib has been widely used to treat multiple myeloma and other hematological malignancies. However, not much is known about its effect on solid tumors. The aim of this study was to study the effect of Bortezomib on human esophageal cancer cell lines and investigate the potential tar...

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Veröffentlicht in:	Technology in cancer research & treatment 2019, Vol.18, p.1533033819842546-1533033819842546
Hauptverfasser:	Ao, Nannan, Dai, Yingchu, Chen, Qianping, Feng, Yang, Yu, Jingping, Wang, Chang, Liu, Fenju, Li, Ming, Liu, Geng
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Apoptosis Apoptosis - drug effects Bortezomib Bortezomib - pharmacology Calcium (reticular) Carcinoma - drug therapy Carcinoma - genetics Carcinoma - pathology Cell cycle Cell Cycle Proteins - genetics Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cell viability Cullin Proteins - genetics DNA microarrays Endoplasmic reticulum Epithelial cells Epithelial Cells - drug effects Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophagus Flow Cytometry G2 Phase Cell Cycle Checkpoints - drug effects Gadd45A protein Gene Expression Regulation, Neoplastic - drug effects Genomes Histone Deacetylase 6 - genetics Humans Microarray Analysis mRNA Multiple myeloma Neoplasm Proteins - genetics Original Polymerase chain reaction Propidium iodide Proteasomes RNA, Messenger - genetics Solid tumors Targeted cancer therapy Tumor cell lines Ubiquitins - genetics Wnt protein Wnt Signaling Pathway - drug effects
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