Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit

Calmodulin (CaM) is a calcium sensor protein that directly interacts with the dual-specificity (lipid and protein) kinase PI3Kα through the SH2 domains of the p85 regulatory subunit. In adenocarcinomas, the CaM interaction removes the autoinhibition of the p110 catalytic subunit of PI3Kα, leading to...

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Veröffentlicht in:	Biochemistry (Easton) 2018-03, Vol.57 (12), p.1917-1928
Hauptverfasser:	Wang, Guanqiao, Zhang, Mingzhen, Jang, Hyunbum, Lu, Shaoyong, Lin, Shizhou, Chen, Guoqiang, Nussinov, Ruth, Zhang, Jian, Gaponenko, Vadim
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma Adenocarcinoma - chemistry Adenocarcinoma - metabolism Amino Acid Motifs amino acid sequences binding sites calcium calmodulin Calmodulin - chemistry Calmodulin - metabolism cell proliferation Class Ia Phosphatidylinositol 3-Kinase - chemistry Class Ia Phosphatidylinositol 3-Kinase - metabolism Humans lipids Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism nuclear magnetic resonance spectroscopy phosphotransferases (kinases) protein subunits protein-protein interactions sequence analysis solvents src Homology Domains tryptophan
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