G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity

HIV-1 and herpes simplex virus type-2 (HSV-2) represent two of the most relevant sexually transmitted diseases (STDs) worldwide. Moreover, each year there are >200 million pregnancies worldwide, and more than half are unintended. Continued high rates of unintended pregnancies and spread of HIV-1...

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Veröffentlicht in:	International journal of nanomedicine 2019-01, Vol.14, p.2371-2381
Hauptverfasser:	Ceña-Diez, Rafael, Martin-Moreno, Alba, de la Mata, F Javier, Gómez-Ramirez, Rafael, Muñoz, Eduardo, Ardoy, Manuel, Muñoz-Fernández, Ma Ángeles
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - pharmacology Cell Proliferation - drug effects Chlorocebus aethiops Contraceptive Agents - pharmacology Dendrimers - pharmacology Female Herpesvirus 2, Human - drug effects Humans Leukocytes, Mononuclear - drug effects Male Mice, Inbred BALB C Original Research Saponins - pharmacology Silanes - pharmacology Sperm Capacitation - drug effects Spermatozoa - drug effects Toxicity Tests Triterpenes - pharmacology Vagina - drug effects Vagina - microbiology Vero Cells
Online-Zugang:	Volltext
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