Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution

The breadth and importance of RNA modifications are growing rapidly as modified ribonucleotides can impact the sequence, structure, function, stability, and fate of RNAs and their interactions with other molecules. Therefore, knowing cellular RNA modifications at single-base resolution could provide...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-04, Vol.116 (14), p.6784-6789
Hauptverfasser:	Khoddami, Vahid, Yerra, Archana, Mosbruger, Timothy L., Fleming, Aaron M., Burrows, Cynthia J., Cairns, Bradley R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Bisulfite Clonal deletion Gene deletion Gene expression Gene Expression Profiling - methods Gene sequencing HeLa Cells Humans Magnesium Mapping Nucleotide sequence Organic chemistry Physical Sciences Ribonucleic acid Ribonucleotides Ribose Ring opening RNA RNA modification RNA Processing, Post-Transcriptional - physiology RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Ribosomal - genetics RNA, Ribosomal - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism Sequence Analysis, RNA - methods Structure-function relationships
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