Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis

Heparin-binding EGF-like growth factor (HB-EGF) is a representative EGF family member that interacts with EGFR under diverse stress environment. Previously, we reported that the HB-EGF-targeting using antisense oligonucleotide (ASO) effectively suppressed an aortic aneurysm in the vessel wall and ci...

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Veröffentlicht in:	Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2019-03, Vol.29 (3), p.306-315
Hauptverfasser:	Kim, S., Graham, M.J., Lee, R.G., Yang, L., Subramanian, V., Layne, J.D., Cai, L., Temel, R.E., Shih, D., Lusis, A.J., Berliner, J.A., Lee, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antisense oligonucleotide Aortic Diseases - blood Aortic Diseases - genetics Aortic Diseases - pathology Aortic Diseases - prevention & control Atherosclerosis Atherosclerosis - blood Atherosclerosis - genetics Atherosclerosis - pathology Atherosclerosis - prevention & control Biomarkers - blood Cholesterol - blood Disease Models, Animal Down-Regulation Female HB-EGF Hep G2 Cells Heparin-binding EGF-like Growth Factor - genetics Heparin-binding EGF-like Growth Factor - metabolism Humans Hyperlipidemia Hyperlipidemias - blood Hyperlipidemias - genetics Hyperlipidemias - prevention & control Insulin Resistance Lipoproteins, VLDL - blood Liver - metabolism Male Mice, Knockout Oligonucleotides, Antisense - administration & dosage Plaque, Atherosclerotic Receptors, LDL - deficiency Receptors, LDL - genetics Triglycerides - blood VLDL
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