Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo: A Cross-sectional Study
Ebola survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after an outbreak, suggesting these areas as potential long-term needs for >10000 West African Ebola survivors. Abstract Background Clinical sequelae of Ebola virus...
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| Veröffentlicht in: | Clinical infectious diseases 2019-04, Vol.68 (8), p.1388-1393 |
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| creator | Kelly, J. Daniel Hoff, Nicole A. Spencer, D’Andre Musene, Kamy Bramble, Matthew S. McIlwain, David Okitundu, Daniel Porco, Travis C. Rutherford, George W. Glymour, M. Maria Bjornson, Zach Mukadi, Patrick Okitolonda-Wemakoy, Emile Nolan, Garry P. Muyembe-Tamfum, Jean Jacques Rimoin, Anne W. |
| description | Ebola survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after an outbreak, suggesting these areas as potential long-term needs for >10000 West African Ebola survivors.
Abstract
Background
Clinical sequelae of Ebola virus disease (EVD) have not been described more than 3 years postoutbreak. We examined survivors and close contacts from the 1995 Ebola outbreak in Kikwit, Democratic Republic of Congo (DRC), and determined prevalence of abnormal neurological, cognitive, and psychological findings and their association with EVD survivorship.
Methods
From August to September 2017, we conducted a cross-sectional study in Kikwit, DRC. Over 2 decades after the EVD outbreak, we recruited EVD survivors and close contacts from the outbreak to undergo physical examination and culturally adapted versions of the Folstein mini-mental status exam (MMSE) and Goldberg anxiety and depression scale (GADS). We estimated the strength of relationships between EVD survivorship and health outcomes using linear regression models by comparing survivors versus close contacts, adjusting for age, sex, educational level, marital status, and healthcare worker status.
Results
We enrolled 20 EVD survivors and 187 close contacts. Among the 20 EVD survivors, 4 (20%) reported at least 1 abnormal neurological symptom, and 3 (15%) had an abnormal neurological examination. Among the 187 close contacts, 14 (11%) reported at least 1 abnormal neurologic symptom, and 9 (5%) had an abnormal neurological examination. EVD survivors had lower mean MMSE and higher mean GADS scores as compared to close contacts (MMSE: adjusted coefficient: −1.85; 95% confidence interval [CI]: −3.63, −0.07; GADS: adjusted coefficient: 3.91; 95% CI: 1.76, 6.04).
Conclusions
EVD survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after Ebola virus outbreaks. |
| doi_str_mv | 10.1093/cid/ciy677 |
| format | Article |
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Abstract
Background
Clinical sequelae of Ebola virus disease (EVD) have not been described more than 3 years postoutbreak. We examined survivors and close contacts from the 1995 Ebola outbreak in Kikwit, Democratic Republic of Congo (DRC), and determined prevalence of abnormal neurological, cognitive, and psychological findings and their association with EVD survivorship.
Methods
From August to September 2017, we conducted a cross-sectional study in Kikwit, DRC. Over 2 decades after the EVD outbreak, we recruited EVD survivors and close contacts from the outbreak to undergo physical examination and culturally adapted versions of the Folstein mini-mental status exam (MMSE) and Goldberg anxiety and depression scale (GADS). We estimated the strength of relationships between EVD survivorship and health outcomes using linear regression models by comparing survivors versus close contacts, adjusting for age, sex, educational level, marital status, and healthcare worker status.
Results
We enrolled 20 EVD survivors and 187 close contacts. Among the 20 EVD survivors, 4 (20%) reported at least 1 abnormal neurological symptom, and 3 (15%) had an abnormal neurological examination. Among the 187 close contacts, 14 (11%) reported at least 1 abnormal neurologic symptom, and 9 (5%) had an abnormal neurological examination. EVD survivors had lower mean MMSE and higher mean GADS scores as compared to close contacts (MMSE: adjusted coefficient: −1.85; 95% confidence interval [CI]: −3.63, −0.07; GADS: adjusted coefficient: 3.91; 95% CI: 1.76, 6.04).
Conclusions
EVD survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after Ebola virus outbreaks.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciy677</identifier><identifier>PMID: 30107392</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>and Commentaries ; ARTICLES AND COMMENTARIES</subject><ispartof>Clinical infectious diseases, 2019-04, Vol.68 (8), p.1388-1393</ispartof><rights>The Author(s) 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-e631f325ba0aee03a7ec35bfc15429a2711bfa63df39f772d08d8de6a5b4d14a3</citedby><cites>FETCH-LOGICAL-c430t-e631f325ba0aee03a7ec35bfc15429a2711bfa63df39f772d08d8de6a5b4d14a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30107392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelly, J. Daniel</creatorcontrib><creatorcontrib>Hoff, Nicole A.</creatorcontrib><creatorcontrib>Spencer, D’Andre</creatorcontrib><creatorcontrib>Musene, Kamy</creatorcontrib><creatorcontrib>Bramble, Matthew S.</creatorcontrib><creatorcontrib>McIlwain, David</creatorcontrib><creatorcontrib>Okitundu, Daniel</creatorcontrib><creatorcontrib>Porco, Travis C.</creatorcontrib><creatorcontrib>Rutherford, George W.</creatorcontrib><creatorcontrib>Glymour, M. Maria</creatorcontrib><creatorcontrib>Bjornson, Zach</creatorcontrib><creatorcontrib>Mukadi, Patrick</creatorcontrib><creatorcontrib>Okitolonda-Wemakoy, Emile</creatorcontrib><creatorcontrib>Nolan, Garry P.</creatorcontrib><creatorcontrib>Muyembe-Tamfum, Jean Jacques</creatorcontrib><creatorcontrib>Rimoin, Anne W.</creatorcontrib><title>Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo: A Cross-sectional Study</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Ebola survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after an outbreak, suggesting these areas as potential long-term needs for >10000 West African Ebola survivors.
Abstract
Background
Clinical sequelae of Ebola virus disease (EVD) have not been described more than 3 years postoutbreak. We examined survivors and close contacts from the 1995 Ebola outbreak in Kikwit, Democratic Republic of Congo (DRC), and determined prevalence of abnormal neurological, cognitive, and psychological findings and their association with EVD survivorship.
Methods
From August to September 2017, we conducted a cross-sectional study in Kikwit, DRC. Over 2 decades after the EVD outbreak, we recruited EVD survivors and close contacts from the outbreak to undergo physical examination and culturally adapted versions of the Folstein mini-mental status exam (MMSE) and Goldberg anxiety and depression scale (GADS). We estimated the strength of relationships between EVD survivorship and health outcomes using linear regression models by comparing survivors versus close contacts, adjusting for age, sex, educational level, marital status, and healthcare worker status.
Results
We enrolled 20 EVD survivors and 187 close contacts. Among the 20 EVD survivors, 4 (20%) reported at least 1 abnormal neurological symptom, and 3 (15%) had an abnormal neurological examination. Among the 187 close contacts, 14 (11%) reported at least 1 abnormal neurologic symptom, and 9 (5%) had an abnormal neurological examination. EVD survivors had lower mean MMSE and higher mean GADS scores as compared to close contacts (MMSE: adjusted coefficient: −1.85; 95% confidence interval [CI]: −3.63, −0.07; GADS: adjusted coefficient: 3.91; 95% CI: 1.76, 6.04).
Conclusions
EVD survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after Ebola virus outbreaks.</description><subject>and Commentaries</subject><subject>ARTICLES AND COMMENTARIES</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9ks1u1DAUhSMEoqWwYQ_yBglVE_BPHCebStW0A4iKIv62luPcZNwm9mA7U83T8KoYZTqCDQvLV7qfvmPpOMueE_yG4Jq91aZNZ1cK8SA7JpyJvOQ1eZhmzKu8qFh1lD0J4QZjQirMH2dHDBMsWE2Ps1-fYPJucL3RaligpeutiWYLC6Rsiz6HnV7fb9HK2NbYPqDz0dkefZ381mydD8h16LJxg0I_jJ8CujABVAC08m5EcQ2I1DXfE9dTbDyoW2Qs-mhu70xcoAsYnfYqGo2-wGZqhjQk5TKFuKfZo04NAZ7t75Ps--ry2_J9fnX97sPy_CrXBcMxh5KRjlHeKKwAMFMCNONNpwkvaK2oIKTpVMnajtWdELTFVVu1UCreFC0pFDvJzmZvyh-h1WCjV4PceDMqv5NOGfnvxpq17N1WlgWnGOMkeL0XePdzghDlaIKGYVAW3BQkxVUlOGVCJPR0RrV3IXjoDjEEyz-NytSonBtN8Mu_H3ZA7ytMwKsZcNPm_6IXM3cTovMHkpZlkf4JZr8BDGy2Mw</recordid><startdate>20190408</startdate><enddate>20190408</enddate><creator>Kelly, J. Daniel</creator><creator>Hoff, Nicole A.</creator><creator>Spencer, D’Andre</creator><creator>Musene, Kamy</creator><creator>Bramble, Matthew S.</creator><creator>McIlwain, David</creator><creator>Okitundu, Daniel</creator><creator>Porco, Travis C.</creator><creator>Rutherford, George W.</creator><creator>Glymour, M. Maria</creator><creator>Bjornson, Zach</creator><creator>Mukadi, Patrick</creator><creator>Okitolonda-Wemakoy, Emile</creator><creator>Nolan, Garry P.</creator><creator>Muyembe-Tamfum, Jean Jacques</creator><creator>Rimoin, Anne W.</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190408</creationdate><title>Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo</title><author>Kelly, J. Daniel ; Hoff, Nicole A. ; Spencer, D’Andre ; Musene, Kamy ; Bramble, Matthew S. ; McIlwain, David ; Okitundu, Daniel ; Porco, Travis C. ; Rutherford, George W. ; Glymour, M. Maria ; Bjornson, Zach ; Mukadi, Patrick ; Okitolonda-Wemakoy, Emile ; Nolan, Garry P. ; Muyembe-Tamfum, Jean Jacques ; Rimoin, Anne W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-e631f325ba0aee03a7ec35bfc15429a2711bfa63df39f772d08d8de6a5b4d14a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>and Commentaries</topic><topic>ARTICLES AND COMMENTARIES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelly, J. Daniel</creatorcontrib><creatorcontrib>Hoff, Nicole A.</creatorcontrib><creatorcontrib>Spencer, D’Andre</creatorcontrib><creatorcontrib>Musene, Kamy</creatorcontrib><creatorcontrib>Bramble, Matthew S.</creatorcontrib><creatorcontrib>McIlwain, David</creatorcontrib><creatorcontrib>Okitundu, Daniel</creatorcontrib><creatorcontrib>Porco, Travis C.</creatorcontrib><creatorcontrib>Rutherford, George W.</creatorcontrib><creatorcontrib>Glymour, M. Maria</creatorcontrib><creatorcontrib>Bjornson, Zach</creatorcontrib><creatorcontrib>Mukadi, Patrick</creatorcontrib><creatorcontrib>Okitolonda-Wemakoy, Emile</creatorcontrib><creatorcontrib>Nolan, Garry P.</creatorcontrib><creatorcontrib>Muyembe-Tamfum, Jean Jacques</creatorcontrib><creatorcontrib>Rimoin, Anne W.</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelly, J. Daniel</au><au>Hoff, Nicole A.</au><au>Spencer, D’Andre</au><au>Musene, Kamy</au><au>Bramble, Matthew S.</au><au>McIlwain, David</au><au>Okitundu, Daniel</au><au>Porco, Travis C.</au><au>Rutherford, George W.</au><au>Glymour, M. Maria</au><au>Bjornson, Zach</au><au>Mukadi, Patrick</au><au>Okitolonda-Wemakoy, Emile</au><au>Nolan, Garry P.</au><au>Muyembe-Tamfum, Jean Jacques</au><au>Rimoin, Anne W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo: A Cross-sectional Study</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2019-04-08</date><risdate>2019</risdate><volume>68</volume><issue>8</issue><spage>1388</spage><epage>1393</epage><pages>1388-1393</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Ebola survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after an outbreak, suggesting these areas as potential long-term needs for >10000 West African Ebola survivors.
Abstract
Background
Clinical sequelae of Ebola virus disease (EVD) have not been described more than 3 years postoutbreak. We examined survivors and close contacts from the 1995 Ebola outbreak in Kikwit, Democratic Republic of Congo (DRC), and determined prevalence of abnormal neurological, cognitive, and psychological findings and their association with EVD survivorship.
Methods
From August to September 2017, we conducted a cross-sectional study in Kikwit, DRC. Over 2 decades after the EVD outbreak, we recruited EVD survivors and close contacts from the outbreak to undergo physical examination and culturally adapted versions of the Folstein mini-mental status exam (MMSE) and Goldberg anxiety and depression scale (GADS). We estimated the strength of relationships between EVD survivorship and health outcomes using linear regression models by comparing survivors versus close contacts, adjusting for age, sex, educational level, marital status, and healthcare worker status.
Results
We enrolled 20 EVD survivors and 187 close contacts. Among the 20 EVD survivors, 4 (20%) reported at least 1 abnormal neurological symptom, and 3 (15%) had an abnormal neurological examination. Among the 187 close contacts, 14 (11%) reported at least 1 abnormal neurologic symptom, and 9 (5%) had an abnormal neurological examination. EVD survivors had lower mean MMSE and higher mean GADS scores as compared to close contacts (MMSE: adjusted coefficient: −1.85; 95% confidence interval [CI]: −3.63, −0.07; GADS: adjusted coefficient: 3.91; 95% CI: 1.76, 6.04).
Conclusions
EVD survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after Ebola virus outbreaks.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>30107392</pmid><doi>10.1093/cid/ciy677</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | and Commentaries ARTICLES AND COMMENTARIES |
| title | Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo: A Cross-sectional Study |
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