Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice

Male infertility is a major concern affecting human reproductive health. Asthenoteratospermia can cause male infertility through reduced motility and abnormal morphology of spermatozoa. Several genes, including DNAH1 and some CFAP family members, are involved in multiple morphological abnormalities...

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Veröffentlicht in:	American journal of human genetics 2019-04, Vol.104 (4), p.738-748
Hauptverfasser:	Liu, Wangjie, He, Xiaojin, Yang, Shenmin, Zouari, Raoudha, Wang, Jiaxiong, Wu, Huan, Kherraf, Zine-Eddine, Liu, Chunyu, Coutton, Charles, Zhao, Rui, Tang, Dongdong, Tang, Shuyan, Lv, Mingrong, Fang, Youyan, Li, Weiyu, Li, Hong, Zhao, Jianyuan, Wang, Xue, Zhao, Shimin, Zhang, Jingjing, Arnoult, Christophe, Jin, Li, Zhang, Zhiguo, Ray, Pierre F., Cao, Yunxia, Zhang, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Alternative Splicing Animals China CRISPR CRISPR-Cas Systems Exome flagella Flagella - pathology Homozygote Humans Infertility, Male - genetics Male male infertility Mice Microtubule-Associated Proteins - genetics MMAF Mutation Phenotype sequencing sperm Sperm Motility Spermatozoa - abnormalities TTC21A Whole Exome Sequencing
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