Spatial regulation of the polarity kinase PAR-1 by parallel inhibitory mechanisms

The MARK/PAR-1 family of kinases are conserved regulators of cell polarity that share a conserved C-terminal kinase-associated domain (KA1). Localization of MARK/PAR-1 kinases to specific regions of the cell cortex is a hallmark of polarized cells. In zygotes, PAR-1 localizes to the posterior cortex...

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Veröffentlicht in:	Development (Cambridge) 2019-03, Vol.146 (6)
Hauptverfasser:	Folkmann, Andrew W, Seydoux, Geraldine
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - physiology Cell Lineage Cell Polarity Cytoplasm - metabolism Gene Expression Regulation, Developmental Green Fluorescent Proteins Humans Microscopy, Confocal Mutation Phosphorylation Protein Domains Protein Kinase C - physiology Protein-Serine-Threonine Kinases - physiology RNA Interference Threonine - chemistry
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