Targeting the phosphorylation site of myristoylated alanine‐rich C kinase substrate alleviates symptoms in a murine model of steroid‐resistant asthma

Background and Purpose Myristoylated alanine‐rich C kinase substrate (MARCKS), a PKC substrate, facilitates mucus production and neutrophil migration. However, the effects of therapeutic procedures targeting the phosphorylation site of MARCKS on steroid‐resistant asthma and the mechanisms underlying...

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Veröffentlicht in:	British journal of pharmacology 2019-04, Vol.176 (8), p.1122-1134
Hauptverfasser:	Wang, Chien‐Neng, Lin, Yu‐Chao, Chang, Bo‐Chun, Chen, Ching‐Hsien, Wu, Reen, Lee, Chen‐Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - therapeutic use Alanine Allergens Alveoli Animal models Animals Asthma Asthma - drug therapy Asthma - metabolism Asthma - pathology Bronchus Chemical compounds Collagen Dexamethasone Disease Models, Animal Drug Resistance Dual energy X-ray absorptiometry Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Female Inflammation Leukocyte migration Leukocytes (eosinophilic) Leukocytes (neutrophilic) Lung - drug effects Lung - metabolism Lung - pathology MARCKS protein Mice Mice, Inbred BALB C Mucus Myristoylated Alanine-Rich C Kinase Substrate - metabolism NAD(P)H oxidase Nitric-oxide synthase Nitrotyrosine Ovalbumin Oxidative stress Peptides Peptides - pharmacology Peptides - therapeutic use Phosphorylation Phosphorylation - drug effects Protein kinase C Research Paper Research Papers Respiratory tract Steroids Substrates Western blotting
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