The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-class cofactors

HOX proteins interact with PBX and MEIS cofactors, which belong to the TALE-class of homeodomain (HD)-containing transcription factors. Although the formation of HOX-PBX complexes depends on a unique conserved HOX motif called hexapeptide (HX), the additional presence of MEIS induces a remodeling of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2019-04, Vol.9 (1), p.5664-5664, Article 5664
Hauptverfasser:	Dard, Amélie, Jia, Yunlong, Reboulet, Jonathan, Bleicher, Françoise, Lavau, Catherine, Merabet, Samir
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 14 14/19 14/35 14/63 631/337 631/337/572 82 82/29 Binding sites Binding Sites - physiology Cell Line Cell Line, Tumor Cell lines Cofactors Complementation Deoxyribonucleic acid DNA DNA - metabolism DNA-Binding Proteins - metabolism HeLa Cells Homeobox Homeodomain Proteins - metabolism HOXA9 protein Humanities and Social Sciences Humans Interfaces Life Sciences MCF-7 Cells multidisciplinary Neoplasm Proteins - metabolism Protein Binding - physiology Proteins Science Science (multidisciplinary) Transcription factors Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!