Oxidative damage of SP‐D abolishes control of eosinophil extracellular DNA trap formation

The asthmatic airways are highly susceptible to inflammatory injury by air pollutants such as ozone (O3), characterized by enhanced activation of eosinophilic granulocytes and a failure of immune protective mechanisms. Eosinophil activation during asthma exacerbation contributes to the proinflammato...

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Veröffentlicht in:	Journal of leukocyte biology 2018-07, Vol.104 (1), p.205-214
Hauptverfasser:	Yousefi, Shida, Sharma, Satish K., Stojkov, Darko, Germic, Nina, Aeschlimann, Salome, Ge, Moyar Q., Flayer, Cameron H., Larson, Erik D., Redai, Imre G., Zhang, Suhong, Koziol‐White, Cynthia J., Karikó, Katalin, Simon, Hans‐Uwe, Haczku, Angela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asthma - immunology Asthma - metabolism Cells, Cultured eosinophil extracellular traps (EETs) eosinophils Eosinophils - drug effects Eosinophils - immunology Eosinophils - metabolism Extracellular Traps - immunology Extracellular Traps - metabolism Humans Hypersensitivity - immunology Hypersensitivity - metabolism Mice Oxidants, Photochemical - toxicity Oxidative Stress - drug effects Oxidative Stress - immunology Ozone - toxicity Pulmonary Surfactant-Associated Protein D - metabolism surfactant pulmonary‐associated protein D (SP‐D)
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