Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation
Abstract BACKGROUND Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH...
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| Veröffentlicht in: | Human reproduction update 2019-05, Vol.25 (3), p.326-343 |
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| creator | Hu, Kai-Lun Chang, Hsun-Ming Zhao, Hong-Cui Yu, Yang Li, Rong Qiao, Jie |
| description | Abstract
BACKGROUND
Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include the secretion of gonadotropins, puberty onset, brain sex differentiation, ovulation and the metabolic regulation of fertility. Furthermore, recent studies have demonstrated the involvement of the kisspeptin system in the processes of implantation and placentation. This review summarizes the current knowledge of the pathophysiological role and utility of these local placental regulatory factors as potential biomarkers during the early human gestation.
OBJECTIVE AND RATIONALE
A successful pregnancy, from the initiation of embryo implantation to parturition, is a complex process that requires the orchestration of a series of events. This review aims to concisely summarize what is known about the role of the kisspeptin system in implantation, placentation, early human pregnancy and pregnancy-related disorders, and to develop strategies for predicting, diagnosing and treating these abnormalities.
SEARCH METHODS
Using the PubMed and Google Scholar databases, we performed comprehensive literature searches in the English language describing the advancement of kisspeptins and the kisspeptin receptor (KISS1R) in implantation, placentation and early pregnancy in humans, since its initial identification in 1996 and ending in July 2018.
OUTCOMES
Recent studies have shown the coordinated spatial and temporal expression patterns of kisspeptins and KISS1R during human pregnancy. The experimental data gathered recently suggest putative roles of kisspeptin signaling in the regulation of trophoblast invasion, embryo implantation, placentation and early pregnancy. Dysregulation of the kisspeptin system may negatively affect the processes of implantation as well as placentation. Clinical studies indicate that the circulating levels of kisspeptins or the expression levels of kisspeptin/KISS1R in the placental tissues may be used as potential diagnostic markers for women with miscarriage and gestational trophoblastic neoplasia.
WIDER IMPLICATIONS
Comprehensive research on the pathophysiological role of the kisspeptin/KISS1R system in implantation and placentation will provide a dynamic and powerful approach to u |
| doi_str_mv | 10.1093/humupd/dmy046 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6450039</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/humupd/dmy046</oup_id><sourcerecordid>2179388803</sourcerecordid><originalsourceid>FETCH-LOGICAL-c486t-f4cf32547cd1dc561e2b1523cbd42c7e1b04b2243d151003f4882ddbed3f2abd3</originalsourceid><addsrcrecordid>eNqFkTtPwzAUhS0EouUxsqKMLKF-xUkWJFTxkirBACuWYzvUkMTBdpD673GV0sLE5OPro-9c6wBwhuAlgiWZLYd26NVMtStI2R6YIspgigkr96MmWZbSvGATcOT9O4SIoSI_BBMCGS0Jo1Pw-mSD7oIRTeJso31SW5eEpU4-jPe97oPpZjuZOC2jiBa_8kG3SRyZtm9EF0QwtktEp5J4lXozOAEHtWi8Pt2cx-Dl9uZ5fp8uHu8e5teLVNKChbSmsiY4o7lUSMmMIY0rlGEiK0WxzDWqIK0wpkShDEFIaloUWKlKK1JjUSlyDK5Gbj9UrVbrfCca3jvTCrfiVhj-96UzS_5mvzijWeSVEXCxATj7OWgfeGu81E38mraD5xjlJSmKApJoTUerdNZ7p-ttDIJ83QkfO-FjJ9F__nu3rfunhF22Hfp_WN_IW5wl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2179388803</pqid></control><display><type>article</type><title>Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><source>Oxford Journals</source><creator>Hu, Kai-Lun ; Chang, Hsun-Ming ; Zhao, Hong-Cui ; Yu, Yang ; Li, Rong ; Qiao, Jie</creator><creatorcontrib>Hu, Kai-Lun ; Chang, Hsun-Ming ; Zhao, Hong-Cui ; Yu, Yang ; Li, Rong ; Qiao, Jie</creatorcontrib><description>Abstract
BACKGROUND
Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include the secretion of gonadotropins, puberty onset, brain sex differentiation, ovulation and the metabolic regulation of fertility. Furthermore, recent studies have demonstrated the involvement of the kisspeptin system in the processes of implantation and placentation. This review summarizes the current knowledge of the pathophysiological role and utility of these local placental regulatory factors as potential biomarkers during the early human gestation.
OBJECTIVE AND RATIONALE
A successful pregnancy, from the initiation of embryo implantation to parturition, is a complex process that requires the orchestration of a series of events. This review aims to concisely summarize what is known about the role of the kisspeptin system in implantation, placentation, early human pregnancy and pregnancy-related disorders, and to develop strategies for predicting, diagnosing and treating these abnormalities.
SEARCH METHODS
Using the PubMed and Google Scholar databases, we performed comprehensive literature searches in the English language describing the advancement of kisspeptins and the kisspeptin receptor (KISS1R) in implantation, placentation and early pregnancy in humans, since its initial identification in 1996 and ending in July 2018.
OUTCOMES
Recent studies have shown the coordinated spatial and temporal expression patterns of kisspeptins and KISS1R during human pregnancy. The experimental data gathered recently suggest putative roles of kisspeptin signaling in the regulation of trophoblast invasion, embryo implantation, placentation and early pregnancy. Dysregulation of the kisspeptin system may negatively affect the processes of implantation as well as placentation. Clinical studies indicate that the circulating levels of kisspeptins or the expression levels of kisspeptin/KISS1R in the placental tissues may be used as potential diagnostic markers for women with miscarriage and gestational trophoblastic neoplasia.
WIDER IMPLICATIONS
Comprehensive research on the pathophysiological role of the kisspeptin/KISS1R system in implantation and placentation will provide a dynamic and powerful approach to understanding the processes of early pregnancy, with potential applications in observational and analytic screening as well as the diagnosis, prognosis and treatment of implantation failure and early pregnancy-related disorders.</description><identifier>ISSN: 1355-4786</identifier><identifier>EISSN: 1460-2369</identifier><identifier>DOI: 10.1093/humupd/dmy046</identifier><identifier>PMID: 30649364</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Embryo Implantation - physiology ; Female ; Fertility - physiology ; Gonadotropin-Releasing Hormone - metabolism ; Humans ; Kisspeptins - metabolism ; Ovulation - physiology ; Placenta - metabolism ; Placentation - physiology ; Pregnancy ; Receptors, Kisspeptin-1 - metabolism ; Reproduction - physiology ; Review ; Signal Transduction - physiology</subject><ispartof>Human reproduction update, 2019-05, Vol.25 (3), p.326-343</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-f4cf32547cd1dc561e2b1523cbd42c7e1b04b2243d151003f4882ddbed3f2abd3</citedby><cites>FETCH-LOGICAL-c486t-f4cf32547cd1dc561e2b1523cbd42c7e1b04b2243d151003f4882ddbed3f2abd3</cites><orcidid>0000-0003-0305-5579 ; 0000-0003-2126-1376 ; 0000-0002-4310-1966</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30649364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Kai-Lun</creatorcontrib><creatorcontrib>Chang, Hsun-Ming</creatorcontrib><creatorcontrib>Zhao, Hong-Cui</creatorcontrib><creatorcontrib>Yu, Yang</creatorcontrib><creatorcontrib>Li, Rong</creatorcontrib><creatorcontrib>Qiao, Jie</creatorcontrib><title>Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation</title><title>Human reproduction update</title><addtitle>Hum Reprod Update</addtitle><description>Abstract
BACKGROUND
Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include the secretion of gonadotropins, puberty onset, brain sex differentiation, ovulation and the metabolic regulation of fertility. Furthermore, recent studies have demonstrated the involvement of the kisspeptin system in the processes of implantation and placentation. This review summarizes the current knowledge of the pathophysiological role and utility of these local placental regulatory factors as potential biomarkers during the early human gestation.
OBJECTIVE AND RATIONALE
A successful pregnancy, from the initiation of embryo implantation to parturition, is a complex process that requires the orchestration of a series of events. This review aims to concisely summarize what is known about the role of the kisspeptin system in implantation, placentation, early human pregnancy and pregnancy-related disorders, and to develop strategies for predicting, diagnosing and treating these abnormalities.
SEARCH METHODS
Using the PubMed and Google Scholar databases, we performed comprehensive literature searches in the English language describing the advancement of kisspeptins and the kisspeptin receptor (KISS1R) in implantation, placentation and early pregnancy in humans, since its initial identification in 1996 and ending in July 2018.
OUTCOMES
Recent studies have shown the coordinated spatial and temporal expression patterns of kisspeptins and KISS1R during human pregnancy. The experimental data gathered recently suggest putative roles of kisspeptin signaling in the regulation of trophoblast invasion, embryo implantation, placentation and early pregnancy. Dysregulation of the kisspeptin system may negatively affect the processes of implantation as well as placentation. Clinical studies indicate that the circulating levels of kisspeptins or the expression levels of kisspeptin/KISS1R in the placental tissues may be used as potential diagnostic markers for women with miscarriage and gestational trophoblastic neoplasia.
WIDER IMPLICATIONS
Comprehensive research on the pathophysiological role of the kisspeptin/KISS1R system in implantation and placentation will provide a dynamic and powerful approach to understanding the processes of early pregnancy, with potential applications in observational and analytic screening as well as the diagnosis, prognosis and treatment of implantation failure and early pregnancy-related disorders.</description><subject>Animals</subject><subject>Embryo Implantation - physiology</subject><subject>Female</subject><subject>Fertility - physiology</subject><subject>Gonadotropin-Releasing Hormone - metabolism</subject><subject>Humans</subject><subject>Kisspeptins - metabolism</subject><subject>Ovulation - physiology</subject><subject>Placenta - metabolism</subject><subject>Placentation - physiology</subject><subject>Pregnancy</subject><subject>Receptors, Kisspeptin-1 - metabolism</subject><subject>Reproduction - physiology</subject><subject>Review</subject><subject>Signal Transduction - physiology</subject><issn>1355-4786</issn><issn>1460-2369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkTtPwzAUhS0EouUxsqKMLKF-xUkWJFTxkirBACuWYzvUkMTBdpD673GV0sLE5OPro-9c6wBwhuAlgiWZLYd26NVMtStI2R6YIspgigkr96MmWZbSvGATcOT9O4SIoSI_BBMCGS0Jo1Pw-mSD7oIRTeJso31SW5eEpU4-jPe97oPpZjuZOC2jiBa_8kG3SRyZtm9EF0QwtktEp5J4lXozOAEHtWi8Pt2cx-Dl9uZ5fp8uHu8e5teLVNKChbSmsiY4o7lUSMmMIY0rlGEiK0WxzDWqIK0wpkShDEFIaloUWKlKK1JjUSlyDK5Gbj9UrVbrfCca3jvTCrfiVhj-96UzS_5mvzijWeSVEXCxATj7OWgfeGu81E38mraD5xjlJSmKApJoTUerdNZ7p-ttDIJ83QkfO-FjJ9F__nu3rfunhF22Hfp_WN_IW5wl</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Hu, Kai-Lun</creator><creator>Chang, Hsun-Ming</creator><creator>Zhao, Hong-Cui</creator><creator>Yu, Yang</creator><creator>Li, Rong</creator><creator>Qiao, Jie</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0305-5579</orcidid><orcidid>https://orcid.org/0000-0003-2126-1376</orcidid><orcidid>https://orcid.org/0000-0002-4310-1966</orcidid></search><sort><creationdate>20190501</creationdate><title>Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation</title><author>Hu, Kai-Lun ; Chang, Hsun-Ming ; Zhao, Hong-Cui ; Yu, Yang ; Li, Rong ; Qiao, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-f4cf32547cd1dc561e2b1523cbd42c7e1b04b2243d151003f4882ddbed3f2abd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Embryo Implantation - physiology</topic><topic>Female</topic><topic>Fertility - physiology</topic><topic>Gonadotropin-Releasing Hormone - metabolism</topic><topic>Humans</topic><topic>Kisspeptins - metabolism</topic><topic>Ovulation - physiology</topic><topic>Placenta - metabolism</topic><topic>Placentation - physiology</topic><topic>Pregnancy</topic><topic>Receptors, Kisspeptin-1 - metabolism</topic><topic>Reproduction - physiology</topic><topic>Review</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Kai-Lun</creatorcontrib><creatorcontrib>Chang, Hsun-Ming</creatorcontrib><creatorcontrib>Zhao, Hong-Cui</creatorcontrib><creatorcontrib>Yu, Yang</creatorcontrib><creatorcontrib>Li, Rong</creatorcontrib><creatorcontrib>Qiao, Jie</creatorcontrib><collection>Oxford University Press Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human reproduction update</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Kai-Lun</au><au>Chang, Hsun-Ming</au><au>Zhao, Hong-Cui</au><au>Yu, Yang</au><au>Li, Rong</au><au>Qiao, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation</atitle><jtitle>Human reproduction update</jtitle><addtitle>Hum Reprod Update</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>25</volume><issue>3</issue><spage>326</spage><epage>343</epage><pages>326-343</pages><issn>1355-4786</issn><eissn>1460-2369</eissn><abstract>Abstract
BACKGROUND
Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include the secretion of gonadotropins, puberty onset, brain sex differentiation, ovulation and the metabolic regulation of fertility. Furthermore, recent studies have demonstrated the involvement of the kisspeptin system in the processes of implantation and placentation. This review summarizes the current knowledge of the pathophysiological role and utility of these local placental regulatory factors as potential biomarkers during the early human gestation.
OBJECTIVE AND RATIONALE
A successful pregnancy, from the initiation of embryo implantation to parturition, is a complex process that requires the orchestration of a series of events. This review aims to concisely summarize what is known about the role of the kisspeptin system in implantation, placentation, early human pregnancy and pregnancy-related disorders, and to develop strategies for predicting, diagnosing and treating these abnormalities.
SEARCH METHODS
Using the PubMed and Google Scholar databases, we performed comprehensive literature searches in the English language describing the advancement of kisspeptins and the kisspeptin receptor (KISS1R) in implantation, placentation and early pregnancy in humans, since its initial identification in 1996 and ending in July 2018.
OUTCOMES
Recent studies have shown the coordinated spatial and temporal expression patterns of kisspeptins and KISS1R during human pregnancy. The experimental data gathered recently suggest putative roles of kisspeptin signaling in the regulation of trophoblast invasion, embryo implantation, placentation and early pregnancy. Dysregulation of the kisspeptin system may negatively affect the processes of implantation as well as placentation. Clinical studies indicate that the circulating levels of kisspeptins or the expression levels of kisspeptin/KISS1R in the placental tissues may be used as potential diagnostic markers for women with miscarriage and gestational trophoblastic neoplasia.
WIDER IMPLICATIONS
Comprehensive research on the pathophysiological role of the kisspeptin/KISS1R system in implantation and placentation will provide a dynamic and powerful approach to understanding the processes of early pregnancy, with potential applications in observational and analytic screening as well as the diagnosis, prognosis and treatment of implantation failure and early pregnancy-related disorders.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>30649364</pmid><doi>10.1093/humupd/dmy046</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0003-0305-5579</orcidid><orcidid>https://orcid.org/0000-0003-2126-1376</orcidid><orcidid>https://orcid.org/0000-0002-4310-1966</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Human reproduction update, 2019-05, Vol.25 (3), p.326-343 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library; Oxford Journals |
| subjects | Animals Embryo Implantation - physiology Female Fertility - physiology Gonadotropin-Releasing Hormone - metabolism Humans Kisspeptins - metabolism Ovulation - physiology Placenta - metabolism Placentation - physiology Pregnancy Receptors, Kisspeptin-1 - metabolism Reproduction - physiology Review Signal Transduction - physiology |
| title | Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation |
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