Gene Promoter Methylation in Endometrial Carcinogenesis

Up to 60% of untreated atypical hyperplastic endometrium will develop into endometrial carcinoma (EC), and for those who underwent a hysterectomy a coexisting EC is found in up to 50%. Gene promoter methylation might be related to the EC development. The aim of this study is to determine changes in...

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Veröffentlicht in:	Pathology oncology research 2019-04, Vol.25 (2), p.659-667
Hauptverfasser:	Cornel, Karlijn M. C., Wouters, Kim, Van de Vijver, Koen K., van der Wurff, Anneke A. M., van Engeland, Manon, Kruitwagen, Roy F. P. M., Pijnenborg, Johanna M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research Carcinogenesis Carcinogenesis - genetics Carcinogens Carcinoma Cyclin-Dependent Kinase Inhibitor p16 - genetics DNA methylation DNA Methylation - genetics DNA Modification Methylases - genetics DNA Repair Enzymes - genetics Endometrial cancer Endometrial Neoplasms - genetics Endometrium Female Genes, p16 Humans Hyperplasia Hyperplasia - genetics Hysterectomy Immunology K-Ras protein Lesions Middle Aged Mutation MutL Protein Homolog 1 - genetics Oncology Original Original Article Pathology Precancerous Conditions - genetics Promoter Regions, Genetic - genetics Retrospective Studies Runx3 protein Tumor Suppressor Proteins - genetics Uterine cancer
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