Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource
Direct in vivo assessment of pancreatic islet-cells for the study of the pathophysiology of diabetes in humans is hampered by anatomical and technological hurdles. To date, most of the information that has been generated is derived from histological studies performed on pancreatic tissue from autops...
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| Veröffentlicht in: | Diabetologia 2018-04, Vol.61 (4), p.770-774 |
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| creator | Marchetti, Piero Suleiman, Mara Marselli, Lorella |
| description | Direct in vivo assessment of pancreatic islet-cells for the study of the pathophysiology of diabetes in humans is hampered by anatomical and technological hurdles. To date, most of the information that has been generated is derived from histological studies performed on pancreatic tissue from autopsy, surgery, in vivo biopsy or organ donation. Each approach has its advantages and disadvantages (as summarised in this commentary); however, in this edition of
Diabetologia
, Kusmartseva et al (
https://doi.org/10.1007/s00125-017-4494-x
) provide further evidence to support the use of organ donor pancreases for the study of human diabetes. They show that length of terminal hospitalisation of organ donors prior to death does not seem to influence the frequency of inflammatory cells infiltrating the pancreas and the replication of beta cells. These findings are reassuring, demonstrating the reliability of this precious and valuable resource for human islet cells research. |
| doi_str_mv | 10.1007/s00125-018-4546-x |
| format | Article |
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Diabetologia
, Kusmartseva et al (
https://doi.org/10.1007/s00125-017-4494-x
) provide further evidence to support the use of organ donor pancreases for the study of human diabetes. They show that length of terminal hospitalisation of organ donors prior to death does not seem to influence the frequency of inflammatory cells infiltrating the pancreas and the replication of beta cells. These findings are reassuring, demonstrating the reliability of this precious and valuable resource for human islet cells research.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-018-4546-x</identifier><identifier>PMID: 29354869</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Autopsy ; Beta cells ; Biopsy ; Blood & organ donations ; Commentary ; Diabetes ; Diabetes mellitus ; Histology ; Human Physiology ; Humans ; Inflammation ; Internal Medicine ; Islet cells ; Islets of Langerhans ; Islets of Langerhans Transplantation ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Organ donors ; Pancreas ; Pancrelipase ; Reproducibility of Results ; Surgery</subject><ispartof>Diabetologia, 2018-04, Vol.61 (4), p.770-774</ispartof><rights>The Author(s) 2018</rights><rights>Diabetologia is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-3cdd51a71f7b01a29c056399070afb1d089f46079f9a41ea1a48d84dbbc6920c3</citedby><cites>FETCH-LOGICAL-c536t-3cdd51a71f7b01a29c056399070afb1d089f46079f9a41ea1a48d84dbbc6920c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00125-018-4546-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00125-018-4546-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29354869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marchetti, Piero</creatorcontrib><creatorcontrib>Suleiman, Mara</creatorcontrib><creatorcontrib>Marselli, Lorella</creatorcontrib><title>Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><addtitle>Diabetologia</addtitle><description>Direct in vivo assessment of pancreatic islet-cells for the study of the pathophysiology of diabetes in humans is hampered by anatomical and technological hurdles. To date, most of the information that has been generated is derived from histological studies performed on pancreatic tissue from autopsy, surgery, in vivo biopsy or organ donation. Each approach has its advantages and disadvantages (as summarised in this commentary); however, in this edition of
Diabetologia
, Kusmartseva et al (
https://doi.org/10.1007/s00125-017-4494-x
) provide further evidence to support the use of organ donor pancreases for the study of human diabetes. They show that length of terminal hospitalisation of organ donors prior to death does not seem to influence the frequency of inflammatory cells infiltrating the pancreas and the replication of beta cells. These findings are reassuring, demonstrating the reliability of this precious and valuable resource for human islet cells research.</description><subject>Autopsy</subject><subject>Beta cells</subject><subject>Biopsy</subject><subject>Blood & organ donations</subject><subject>Commentary</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Histology</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Islet cells</subject><subject>Islets of Langerhans</subject><subject>Islets of Langerhans Transplantation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Organ donors</subject><subject>Pancreas</subject><subject>Pancrelipase</subject><subject>Reproducibility of Results</subject><subject>Surgery</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc1q3DAUhUVpaaZpHyCbIOgmG7dXtixLWQRC6B8EsmmhO3EtyWMHj-RK9jDz9tVk0pAWurKs890jHR1Czhh8YADNxwTAyroAJgtec1HsXpAV41VZAC_lS7I6yAWT4ucJeZPSPQBUGXtNTkqVF1KoFdndxTV6aoMPkU7oTXSYXKJd_p17R9O82D0NHe2XTeaGNLqZGjeOtB_SHMaw3lP0No_OfZj6fRoe9i4p0ik6M4QlPehbHBdsR0ejS2GJxr0lrzock3v3-D0lPz5_-n7ztbi9-_Lt5vq2MHUl5qIy1tYMG9Y1LTAslYFaVEpBA9i1zIJUHRfQqE4hZw4Zcmklt21rhCrBVKfk6ug7Le3GWeP8HHHUUxw2GPc64KD_VvzQ63XYasG5AsGzwcWjQQy_FpdmvRnS4QXQu5xOMyWVYjVnMqPv_0Hvc1af42VKVWXNq6bOFDtSJoaUouueLsNAH3rVx1517lUfetW7PHP-PMXTxJ8iM1AegZQlv3bx2dH_df0NBi6xSQ</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Marchetti, Piero</creator><creator>Suleiman, Mara</creator><creator>Marselli, Lorella</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180401</creationdate><title>Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource</title><author>Marchetti, Piero ; 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To date, most of the information that has been generated is derived from histological studies performed on pancreatic tissue from autopsy, surgery, in vivo biopsy or organ donation. Each approach has its advantages and disadvantages (as summarised in this commentary); however, in this edition of
Diabetologia
, Kusmartseva et al (
https://doi.org/10.1007/s00125-017-4494-x
) provide further evidence to support the use of organ donor pancreases for the study of human diabetes. They show that length of terminal hospitalisation of organ donors prior to death does not seem to influence the frequency of inflammatory cells infiltrating the pancreas and the replication of beta cells. These findings are reassuring, demonstrating the reliability of this precious and valuable resource for human islet cells research.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29354869</pmid><doi>10.1007/s00125-018-4546-x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Autopsy Beta cells Biopsy Blood & organ donations Commentary Diabetes Diabetes mellitus Histology Human Physiology Humans Inflammation Internal Medicine Islet cells Islets of Langerhans Islets of Langerhans Transplantation Medicine Medicine & Public Health Metabolic Diseases Organ donors Pancreas Pancrelipase Reproducibility of Results Surgery |
| title | Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource |
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