Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis
Objective. The aim of this study is to evaluate the efficacy and safety of pulmonary rehabilitation (PR) in patients with idiopathic pulmonary fibrosis (IPF). Methods. Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese B...
Gespeichert in:
| Veröffentlicht in: | BioMed research international 2019-01, Vol.2019 (2019), p.1-9 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9 |
|---|---|
| container_issue | 2019 |
| container_start_page | 1 |
| container_title | BioMed research international |
| container_volume | 2019 |
| creator | Jian-sheng, Li Xie, Yang Liu, Ran Wang, Liaoyao Li, Xuanlin Xue-qing, Yu Li, Suyun |
| description | Objective. The aim of this study is to evaluate the efficacy and safety of pulmonary rehabilitation (PR) in patients with idiopathic pulmonary fibrosis (IPF). Methods. Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature Database (SinoMed) were comprehensively searched. Randomized controlled trials (RCTs) that investigated the effects of PR for IPF patients were included. Literature selection and data extraction were conducted by two review authors independently. The Cochrane Collaboration’s Risk of Bias tool and RevMan software (version 5.3) were used to evaluate the quality of studies and conduct statistical analysis, respectively. Results. Seven studies (190 participants) were included. PR had a significant effect on six-minute walk distance (6MWD) (MD:48.60; 95%CI: 29.03 to 68.18; Z=4.87, P |
| doi_str_mv | 10.1155/2019/8498603 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6448340</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A619216083</galeid><sourcerecordid>A619216083</sourcerecordid><originalsourceid>FETCH-LOGICAL-c565t-aacba21f6e5b1ccb1ff8c9b272d0e230e439de076e6298079c7a2307edd2ce033</originalsourceid><addsrcrecordid>eNqNkUFv1DAQhSMEolXpjTOyxAUJQsd24sQckFZVC5UWsUA5W44z6bpK7GInLcuvx2GXLXDCF1sz37yZ8cuypxReU1qWJwyoPKkLWQvgD7JDxmmRC1rQh_s35wfZcYzXkE5NBUjxODvgFKhgAIfZj9XUD97psCGfca0b29tRj9Y70vlAzr5jMDYiufQ9Bu0MEu1a8mnSCdsQ35Gl7ZBYRy5W52SVCtGN8Q1ZkC-bOOKQAibp3lq8-1X4AUedL5zuN9HGJ9mjTvcRj3f3Ufb1_Ozy9H2-_Pju4nSxzE0pyjHX2jSa0U5g2VBjGtp1tZENq1gLyDhgwWWLUAkUTNZQSVPpFK6wbZlB4Pwoe7vVvZmaAVuTRgy6VzfBDmlt5bVVf2ecXasrf6tEUdS8gCTwYicQ_LcJ46gGGw32vXbop6gYo1ymry2rhD7_B732U0gLzxRAKWVRwT11pXtU1nU-9TWzqFoIKlnSque5X20pE3yMAbv9yBTU7L6a3Vc79xP-7M819_BvrxPwcgusrWv1nf1PueRi6q3vacoqyYH_BKevwHw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2200599470</pqid></control><display><type>article</type><title>Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Jian-sheng, Li ; Xie, Yang ; Liu, Ran ; Wang, Liaoyao ; Li, Xuanlin ; Xue-qing, Yu ; Li, Suyun</creator><contributor>Luppi, Fabrizio ; Fabrizio Luppi</contributor><creatorcontrib>Jian-sheng, Li ; Xie, Yang ; Liu, Ran ; Wang, Liaoyao ; Li, Xuanlin ; Xue-qing, Yu ; Li, Suyun ; Luppi, Fabrizio ; Fabrizio Luppi</creatorcontrib><description>Objective. The aim of this study is to evaluate the efficacy and safety of pulmonary rehabilitation (PR) in patients with idiopathic pulmonary fibrosis (IPF). Methods. Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature Database (SinoMed) were comprehensively searched. Randomized controlled trials (RCTs) that investigated the effects of PR for IPF patients were included. Literature selection and data extraction were conducted by two review authors independently. The Cochrane Collaboration’s Risk of Bias tool and RevMan software (version 5.3) were used to evaluate the quality of studies and conduct statistical analysis, respectively. Results. Seven studies (190 participants) were included. PR had a significant effect on six-minute walk distance (6MWD) (MD:48.60; 95%CI: 29.03 to 68.18; Z=4.87, P<0.00001), and 6MWD was improved more in subgroup analysis including studies conducted in Asia (MD: 53.62; 95%CI: 30.48 to 76.66; Z=4.54, P<0.00001) and Europe (MD:54.10; 95% CI: 26.65 to 101.56; Z=2.23, P=0.03). Forced vital capacity (FVC%) was higher (MD: 3.69; 95%CI: 0.16 to 7.23; Z=2.05, P=0.04). St. George’s Respiratory Questionnaire (SGRQ)/IPF-specific SGRQ (SGRQ-I) total score was lower (MD: -7.87; 95% CI: -11.44 to -4.30; Z=4.32, P<0.0001). No significant effects were found for lung diffusing capacity determined by the single-breath technique (DLCO%) (MD: 3.02; 95%CI: -0.38 to 6.42; Z=1.74, P=0.08). Conclusions. This study suggests that PR may enhance exercise capacity and improve quality of life in IPF patients. Besides, PR may also delay the decline of lung function of patients with IPF. However, further research should more fully assess the efficacy and safety of PR for IPF.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2019/8498603</identifier><identifier>PMID: 31016200</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Analysis ; Bias ; Biomedical data ; Clinical trials ; Collaboration ; Critical care ; Exercise - physiology ; Exercise Tolerance - physiology ; Fibrosis ; Fitness training programs ; Handbooks ; Humans ; Idiopathic Pulmonary Fibrosis - physiopathology ; Idiopathic Pulmonary Fibrosis - rehabilitation ; Lung - physiopathology ; Lung diseases ; Meta-analysis ; Online databases ; Patients ; Pulmonary fibrosis ; Quality of Life ; Questionnaires ; Randomized Controlled Trials as Topic ; Rehabilitation ; Respiratory function ; Respiratory tract diseases ; Review ; Safety ; Software ; Statistical analysis ; Studies ; Subgroups ; Systematic review</subject><ispartof>BioMed research international, 2019-01, Vol.2019 (2019), p.1-9</ispartof><rights>Copyright © 2019 Xueqing Yu et al.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Xueqing Yu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Xueqing Yu et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-aacba21f6e5b1ccb1ff8c9b272d0e230e439de076e6298079c7a2307edd2ce033</citedby><cites>FETCH-LOGICAL-c565t-aacba21f6e5b1ccb1ff8c9b272d0e230e439de076e6298079c7a2307edd2ce033</cites><orcidid>0000-0003-1634-7992 ; 0000-0002-6444-6090 ; 0000-0002-0281-322X ; 0000-0002-2714-9353</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448340/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448340/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31016200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Luppi, Fabrizio</contributor><contributor>Fabrizio Luppi</contributor><creatorcontrib>Jian-sheng, Li</creatorcontrib><creatorcontrib>Xie, Yang</creatorcontrib><creatorcontrib>Liu, Ran</creatorcontrib><creatorcontrib>Wang, Liaoyao</creatorcontrib><creatorcontrib>Li, Xuanlin</creatorcontrib><creatorcontrib>Xue-qing, Yu</creatorcontrib><creatorcontrib>Li, Suyun</creatorcontrib><title>Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Objective. The aim of this study is to evaluate the efficacy and safety of pulmonary rehabilitation (PR) in patients with idiopathic pulmonary fibrosis (IPF). Methods. Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature Database (SinoMed) were comprehensively searched. Randomized controlled trials (RCTs) that investigated the effects of PR for IPF patients were included. Literature selection and data extraction were conducted by two review authors independently. The Cochrane Collaboration’s Risk of Bias tool and RevMan software (version 5.3) were used to evaluate the quality of studies and conduct statistical analysis, respectively. Results. Seven studies (190 participants) were included. PR had a significant effect on six-minute walk distance (6MWD) (MD:48.60; 95%CI: 29.03 to 68.18; Z=4.87, P<0.00001), and 6MWD was improved more in subgroup analysis including studies conducted in Asia (MD: 53.62; 95%CI: 30.48 to 76.66; Z=4.54, P<0.00001) and Europe (MD:54.10; 95% CI: 26.65 to 101.56; Z=2.23, P=0.03). Forced vital capacity (FVC%) was higher (MD: 3.69; 95%CI: 0.16 to 7.23; Z=2.05, P=0.04). St. George’s Respiratory Questionnaire (SGRQ)/IPF-specific SGRQ (SGRQ-I) total score was lower (MD: -7.87; 95% CI: -11.44 to -4.30; Z=4.32, P<0.0001). No significant effects were found for lung diffusing capacity determined by the single-breath technique (DLCO%) (MD: 3.02; 95%CI: -0.38 to 6.42; Z=1.74, P=0.08). Conclusions. This study suggests that PR may enhance exercise capacity and improve quality of life in IPF patients. Besides, PR may also delay the decline of lung function of patients with IPF. However, further research should more fully assess the efficacy and safety of PR for IPF.</description><subject>Analysis</subject><subject>Bias</subject><subject>Biomedical data</subject><subject>Clinical trials</subject><subject>Collaboration</subject><subject>Critical care</subject><subject>Exercise - physiology</subject><subject>Exercise Tolerance - physiology</subject><subject>Fibrosis</subject><subject>Fitness training programs</subject><subject>Handbooks</subject><subject>Humans</subject><subject>Idiopathic Pulmonary Fibrosis - physiopathology</subject><subject>Idiopathic Pulmonary Fibrosis - rehabilitation</subject><subject>Lung - physiopathology</subject><subject>Lung diseases</subject><subject>Meta-analysis</subject><subject>Online databases</subject><subject>Patients</subject><subject>Pulmonary fibrosis</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Rehabilitation</subject><subject>Respiratory function</subject><subject>Respiratory tract diseases</subject><subject>Review</subject><subject>Safety</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Systematic review</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUFv1DAQhSMEolXpjTOyxAUJQsd24sQckFZVC5UWsUA5W44z6bpK7GInLcuvx2GXLXDCF1sz37yZ8cuypxReU1qWJwyoPKkLWQvgD7JDxmmRC1rQh_s35wfZcYzXkE5NBUjxODvgFKhgAIfZj9XUD97psCGfca0b29tRj9Y70vlAzr5jMDYiufQ9Bu0MEu1a8mnSCdsQ35Gl7ZBYRy5W52SVCtGN8Q1ZkC-bOOKQAibp3lq8-1X4AUedL5zuN9HGJ9mjTvcRj3f3Ufb1_Ozy9H2-_Pju4nSxzE0pyjHX2jSa0U5g2VBjGtp1tZENq1gLyDhgwWWLUAkUTNZQSVPpFK6wbZlB4Pwoe7vVvZmaAVuTRgy6VzfBDmlt5bVVf2ecXasrf6tEUdS8gCTwYicQ_LcJ46gGGw32vXbop6gYo1ymry2rhD7_B732U0gLzxRAKWVRwT11pXtU1nU-9TWzqFoIKlnSque5X20pE3yMAbv9yBTU7L6a3Vc79xP-7M819_BvrxPwcgusrWv1nf1PueRi6q3vacoqyYH_BKevwHw</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Jian-sheng, Li</creator><creator>Xie, Yang</creator><creator>Liu, Ran</creator><creator>Wang, Liaoyao</creator><creator>Li, Xuanlin</creator><creator>Xue-qing, Yu</creator><creator>Li, Suyun</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1634-7992</orcidid><orcidid>https://orcid.org/0000-0002-6444-6090</orcidid><orcidid>https://orcid.org/0000-0002-0281-322X</orcidid><orcidid>https://orcid.org/0000-0002-2714-9353</orcidid></search><sort><creationdate>20190101</creationdate><title>Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis</title><author>Jian-sheng, Li ; Xie, Yang ; Liu, Ran ; Wang, Liaoyao ; Li, Xuanlin ; Xue-qing, Yu ; Li, Suyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-aacba21f6e5b1ccb1ff8c9b272d0e230e439de076e6298079c7a2307edd2ce033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Bias</topic><topic>Biomedical data</topic><topic>Clinical trials</topic><topic>Collaboration</topic><topic>Critical care</topic><topic>Exercise - physiology</topic><topic>Exercise Tolerance - physiology</topic><topic>Fibrosis</topic><topic>Fitness training programs</topic><topic>Handbooks</topic><topic>Humans</topic><topic>Idiopathic Pulmonary Fibrosis - physiopathology</topic><topic>Idiopathic Pulmonary Fibrosis - rehabilitation</topic><topic>Lung - physiopathology</topic><topic>Lung diseases</topic><topic>Meta-analysis</topic><topic>Online databases</topic><topic>Patients</topic><topic>Pulmonary fibrosis</topic><topic>Quality of Life</topic><topic>Questionnaires</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Rehabilitation</topic><topic>Respiratory function</topic><topic>Respiratory tract diseases</topic><topic>Review</topic><topic>Safety</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Subgroups</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jian-sheng, Li</creatorcontrib><creatorcontrib>Xie, Yang</creatorcontrib><creatorcontrib>Liu, Ran</creatorcontrib><creatorcontrib>Wang, Liaoyao</creatorcontrib><creatorcontrib>Li, Xuanlin</creatorcontrib><creatorcontrib>Xue-qing, Yu</creatorcontrib><creatorcontrib>Li, Suyun</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jian-sheng, Li</au><au>Xie, Yang</au><au>Liu, Ran</au><au>Wang, Liaoyao</au><au>Li, Xuanlin</au><au>Xue-qing, Yu</au><au>Li, Suyun</au><au>Luppi, Fabrizio</au><au>Fabrizio Luppi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Objective. The aim of this study is to evaluate the efficacy and safety of pulmonary rehabilitation (PR) in patients with idiopathic pulmonary fibrosis (IPF). Methods. Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature Database (SinoMed) were comprehensively searched. Randomized controlled trials (RCTs) that investigated the effects of PR for IPF patients were included. Literature selection and data extraction were conducted by two review authors independently. The Cochrane Collaboration’s Risk of Bias tool and RevMan software (version 5.3) were used to evaluate the quality of studies and conduct statistical analysis, respectively. Results. Seven studies (190 participants) were included. PR had a significant effect on six-minute walk distance (6MWD) (MD:48.60; 95%CI: 29.03 to 68.18; Z=4.87, P<0.00001), and 6MWD was improved more in subgroup analysis including studies conducted in Asia (MD: 53.62; 95%CI: 30.48 to 76.66; Z=4.54, P<0.00001) and Europe (MD:54.10; 95% CI: 26.65 to 101.56; Z=2.23, P=0.03). Forced vital capacity (FVC%) was higher (MD: 3.69; 95%CI: 0.16 to 7.23; Z=2.05, P=0.04). St. George’s Respiratory Questionnaire (SGRQ)/IPF-specific SGRQ (SGRQ-I) total score was lower (MD: -7.87; 95% CI: -11.44 to -4.30; Z=4.32, P<0.0001). No significant effects were found for lung diffusing capacity determined by the single-breath technique (DLCO%) (MD: 3.02; 95%CI: -0.38 to 6.42; Z=1.74, P=0.08). Conclusions. This study suggests that PR may enhance exercise capacity and improve quality of life in IPF patients. Besides, PR may also delay the decline of lung function of patients with IPF. However, further research should more fully assess the efficacy and safety of PR for IPF.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31016200</pmid><doi>10.1155/2019/8498603</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1634-7992</orcidid><orcidid>https://orcid.org/0000-0002-6444-6090</orcidid><orcidid>https://orcid.org/0000-0002-0281-322X</orcidid><orcidid>https://orcid.org/0000-0002-2714-9353</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2019-01, Vol.2019 (2019), p.1-9 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6448340 |
| source | MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Analysis Bias Biomedical data Clinical trials Collaboration Critical care Exercise - physiology Exercise Tolerance - physiology Fibrosis Fitness training programs Handbooks Humans Idiopathic Pulmonary Fibrosis - physiopathology Idiopathic Pulmonary Fibrosis - rehabilitation Lung - physiopathology Lung diseases Meta-analysis Online databases Patients Pulmonary fibrosis Quality of Life Questionnaires Randomized Controlled Trials as Topic Rehabilitation Respiratory function Respiratory tract diseases Review Safety Software Statistical analysis Studies Subgroups Systematic review |
| title | Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T03%3A40%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pulmonary%20Rehabilitation%20for%20Exercise%20Tolerance%20and%20Quality%20of%20Life%20in%20IPF%20Patients:%20A%20Systematic%20Review%20and%20Meta-Analysis&rft.jtitle=BioMed%20research%20international&rft.au=Jian-sheng,%20Li&rft.date=2019-01-01&rft.volume=2019&rft.issue=2019&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2019/8498603&rft_dat=%3Cgale_pubme%3EA619216083%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2200599470&rft_id=info:pmid/31016200&rft_galeid=A619216083&rfr_iscdi=true |