Combination of phospholipase Cε knockdown with GANT61 sensitizes castration‑resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway

Castration‑resistant prostate cancer (CRPC) is a major challenge in the treatment of prostate cancer (PCa). Phospholipase Cε (PLCε), an oncogene, has been found to be involved in the carcinogenesis, tumor proliferation and migration of several types of cancer. The effects, however, of PLCε on CRPC r...

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Veröffentlicht in:	Oncology reports 2019-05, Vol.41 (5), p.2689-2702
Hauptverfasser:	Sun, Wei, Li, Luo, Du, Zhongbo, Quan, Zhen, Yuan, Mengjuan, Cheng, Honglin, Gao, Yingying, Luo, Chunli, Wu, Xiaohou
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Animals Antigens Cancer therapies Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - genetics Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Gene Knockdown Techniques Humans Hyperplasia Immunoglobulin G - pharmacology Immunoglobulin G - therapeutic use Male Melphalan - pharmacology Melphalan - therapeutic use Metastasis Mice Mice, Nude Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - metabolism Patients Phenylthiohydantoin - analogs & derivatives Phenylthiohydantoin - pharmacology Phenylthiohydantoin - therapeutic use Phosphoinositide Phospholipase C - genetics Phosphoinositide Phospholipase C - metabolism Prognosis Progression-Free Survival Prostate - pathology Prostate cancer Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - mortality Prostatic Neoplasms, Castration-Resistant - pathology Proteins Pyridines - pharmacology Pyridines - therapeutic use Pyrimidines - pharmacology Pyrimidines - therapeutic use Receptors, Androgen - metabolism RNA, Small Interfering - metabolism Signal Transduction - drug effects Signal Transduction - genetics Survival Analysis Tumors Up-Regulation Xenograft Model Antitumor Assays Zinc Finger Protein GLI1 - antagonists & inhibitors Zinc Finger Protein GLI1 - metabolism Zinc Finger Protein Gli2 - antagonists & inhibitors Zinc Finger Protein Gli2 - metabolism
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