Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and C-reactive protein in the serum of patients with pregnancy-induced hypertension syndrome
Effect and clinical efficacy of magnesium sulfate combined with phentolamine on homocysteine and C-reactive protein in the serum of patients with pregnancy-induced hypertension syndrome were investigated. A total of 96 patients with pregnancy-induced hypertension syndrome who were diagnosed and trea...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2019-05, Vol.17 (5), p.3682-3688 |
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| creator | Ma, Li Li, Liang Han, Ping Meng, Fanchun Jiao, Chunhong Zhang, Hongmei |
| description | Effect and clinical efficacy of magnesium sulfate combined with phentolamine on homocysteine and C-reactive protein in the serum of patients with pregnancy-induced hypertension syndrome were investigated. A total of 96 patients with pregnancy-induced hypertension syndrome who were diagnosed and treated in Jining No. 1 People's Hospital from February 2016 to January 2018 were retrospectively analyzed. The patients were grouped according to the dosage regimen. The patients who received the combination treatment of magnesium sulfate and phentolamine on the basis of magnesium sulfate were included in the observation group, and the patients who were treated with the intravenous infusion of magnesium sulfate alone were included in the control group. Mean arterial pressure (MAP), the content of 24 h urine protein, systolic blood pressure (SBP), diastolic blood pressure (DBP), Hcy, and CRP of the pregnant women were observed. MAP and the content of 24 h urine protein, SBP and DBP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P |
| doi_str_mv | 10.3892/etm.2019.7385 |
| format | Article |
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A total of 96 patients with pregnancy-induced hypertension syndrome who were diagnosed and treated in Jining No. 1 People's Hospital from February 2016 to January 2018 were retrospectively analyzed. The patients were grouped according to the dosage regimen. The patients who received the combination treatment of magnesium sulfate and phentolamine on the basis of magnesium sulfate were included in the observation group, and the patients who were treated with the intravenous infusion of magnesium sulfate alone were included in the control group. Mean arterial pressure (MAP), the content of 24 h urine protein, systolic blood pressure (SBP), diastolic blood pressure (DBP), Hcy, and CRP of the pregnant women were observed. MAP and the content of 24 h urine protein, SBP and DBP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). Hcy and CRP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). The total effective rate of the patients in the observation group was significantly higher than that of the patients in the control group (P<0.05). In conclusion, the meliorative effect of magnesium sulphate combined with phentolamine on the level of MAP, the content of 24 h urine protein, SBP, DBP, Hcy and CRP in pregnant woman had a greater impact than that of the single use of the intravenous infusion of magnesium sulfate in the treatment of pregnancy-induced hypertension syndrome, and the clinical efficacy of magnesium sulphate combined with phentolamine was better, thus worthwhile to promote widely in clinic.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2019.7385</identifier><identifier>PMID: 30988752</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Age ; Analysis ; Blood pressure ; C-reactive protein ; Combination drug therapy ; Drug dosages ; Drug therapy ; Gestational hypertension ; Health aspects ; Homocysteine ; Hypertension ; Magnesium compounds ; Magnesium sulfate ; Maternal & child health ; Medical research ; Pathogenesis ; Patient outcomes ; Phentolamine ; Pregnancy ; Pregnant women ; Proteins ; Sulfates ; Urine ; Vital signs ; Womens health</subject><ispartof>Experimental and therapeutic medicine, 2019-05, Vol.17 (5), p.3682-3688</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Ma et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-29f282e35df2261cd1227e8ab29db7df4af9da038041a7950e508a1d39270eea3</citedby><cites>FETCH-LOGICAL-c412t-29f282e35df2261cd1227e8ab29db7df4af9da038041a7950e508a1d39270eea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447783/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447783/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30988752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Li</creatorcontrib><creatorcontrib>Li, Liang</creatorcontrib><creatorcontrib>Han, Ping</creatorcontrib><creatorcontrib>Meng, Fanchun</creatorcontrib><creatorcontrib>Jiao, Chunhong</creatorcontrib><creatorcontrib>Zhang, Hongmei</creatorcontrib><title>Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and C-reactive protein in the serum of patients with pregnancy-induced hypertension syndrome</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>Effect and clinical efficacy of magnesium sulfate combined with phentolamine on homocysteine and C-reactive protein in the serum of patients with pregnancy-induced hypertension syndrome were investigated. A total of 96 patients with pregnancy-induced hypertension syndrome who were diagnosed and treated in Jining No. 1 People's Hospital from February 2016 to January 2018 were retrospectively analyzed. The patients were grouped according to the dosage regimen. The patients who received the combination treatment of magnesium sulfate and phentolamine on the basis of magnesium sulfate were included in the observation group, and the patients who were treated with the intravenous infusion of magnesium sulfate alone were included in the control group. Mean arterial pressure (MAP), the content of 24 h urine protein, systolic blood pressure (SBP), diastolic blood pressure (DBP), Hcy, and CRP of the pregnant women were observed. MAP and the content of 24 h urine protein, SBP and DBP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). Hcy and CRP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). The total effective rate of the patients in the observation group was significantly higher than that of the patients in the control group (P<0.05). In conclusion, the meliorative effect of magnesium sulphate combined with phentolamine on the level of MAP, the content of 24 h urine protein, SBP, DBP, Hcy and CRP in pregnant woman had a greater impact than that of the single use of the intravenous infusion of magnesium sulfate in the treatment of pregnancy-induced hypertension syndrome, and the clinical efficacy of magnesium sulphate combined with phentolamine was better, thus worthwhile to promote widely in clinic.</description><subject>Age</subject><subject>Analysis</subject><subject>Blood pressure</subject><subject>C-reactive protein</subject><subject>Combination drug therapy</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Gestational hypertension</subject><subject>Health aspects</subject><subject>Homocysteine</subject><subject>Hypertension</subject><subject>Magnesium compounds</subject><subject>Magnesium sulfate</subject><subject>Maternal & child health</subject><subject>Medical research</subject><subject>Pathogenesis</subject><subject>Patient outcomes</subject><subject>Phentolamine</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Proteins</subject><subject>Sulfates</subject><subject>Urine</subject><subject>Vital signs</subject><subject>Womens health</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk9vFCEYxidGY5vao1dD4sXLrMAMO3AxaTb1T9LEi54JCy87NAOMwNTsx_Ibyti1WiOQAC-_93mBPE3zkuBNxwV9C8VvKCZiM3ScPWnOySBoSzBhT09rLDg5ay5zvsW1sS3hnD1vzroa5wOj582Pa2tBFxQtKiMgk5YD0tHvXVDFxbDGvToEyG7xKC-TVQWQCgbNI4QSJ-VdAFTBMfqoj7nAul-BXZtA6eLuAM0prnFUx1okQ6piVXmuNapKRt9dGSsFh6CCPrYumEWDQeNxhlQg5PUm-RhMih5eNM-smjJcnuaL5uv76y-7j-3N5w-fdlc3re4JLS0VlnIKHTOW0i3RhlA6AFd7Ksx-MLZXVhiFO457ogbBMDDMFTGdoAMGUN1F8-5ed172HoyuF01qknNyXqWjjMrJxyfBjfIQ7-S274eBd1XgzUkgxW8L5CK9yxqmSQWIS5aUEkx7MWyHir7-B72NSwr1eb8o3mHK2B_qoCaQLthY6-pVVF4xzvqeb8VadvMfqnYD3ukYwLoaf5TQ3ifoFHNOYB_eSLBcbSarzeRqM7narPKv_v6YB_q3qbqfMVXRpQ</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Ma, Li</creator><creator>Li, Liang</creator><creator>Han, Ping</creator><creator>Meng, Fanchun</creator><creator>Jiao, Chunhong</creator><creator>Zhang, Hongmei</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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A total of 96 patients with pregnancy-induced hypertension syndrome who were diagnosed and treated in Jining No. 1 People's Hospital from February 2016 to January 2018 were retrospectively analyzed. The patients were grouped according to the dosage regimen. The patients who received the combination treatment of magnesium sulfate and phentolamine on the basis of magnesium sulfate were included in the observation group, and the patients who were treated with the intravenous infusion of magnesium sulfate alone were included in the control group. Mean arterial pressure (MAP), the content of 24 h urine protein, systolic blood pressure (SBP), diastolic blood pressure (DBP), Hcy, and CRP of the pregnant women were observed. MAP and the content of 24 h urine protein, SBP and DBP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). Hcy and CRP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). The total effective rate of the patients in the observation group was significantly higher than that of the patients in the control group (P<0.05). In conclusion, the meliorative effect of magnesium sulphate combined with phentolamine on the level of MAP, the content of 24 h urine protein, SBP, DBP, Hcy and CRP in pregnant woman had a greater impact than that of the single use of the intravenous infusion of magnesium sulfate in the treatment of pregnancy-induced hypertension syndrome, and the clinical efficacy of magnesium sulphate combined with phentolamine was better, thus worthwhile to promote widely in clinic.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30988752</pmid><doi>10.3892/etm.2019.7385</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental and therapeutic medicine, 2019-05, Vol.17 (5), p.3682-3688 |
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| source | PubMed Central |
| subjects | Age Analysis Blood pressure C-reactive protein Combination drug therapy Drug dosages Drug therapy Gestational hypertension Health aspects Homocysteine Hypertension Magnesium compounds Magnesium sulfate Maternal & child health Medical research Pathogenesis Patient outcomes Phentolamine Pregnancy Pregnant women Proteins Sulfates Urine Vital signs Womens health |
| title | Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and C-reactive protein in the serum of patients with pregnancy-induced hypertension syndrome |
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