Clinical outcomes of patients with T4 or N1b well-differentiated thyroid cancer after different strategies of adjuvant radioiodine therapy
We aimed to determine whether recombinant human thyrotropin (rhTSH) plus 3.7 GBq could replace thyroid hormone withdrawal (THW) plus 5.55 GBq for adjuvant radioactive iodine (RAI) therapy in differentiated thyroid cancer (DTC) patients with T4 or N1b disease. This study was a retrospective study com...
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| creator | Jeong, Shin Young Lee, Sang-Woo Kim, Wan Wook Jung, Jin Hyang Lee, Won Kee Ahn, Byeong-Cheol Lee, Jaetae |
| description | We aimed to determine whether recombinant human thyrotropin (rhTSH) plus 3.7 GBq could replace thyroid hormone withdrawal (THW) plus 5.55 GBq for adjuvant radioactive iodine (RAI) therapy in differentiated thyroid cancer (DTC) patients with T4 or N1b disease. This study was a retrospective study comparing ablation success rate, response to initial therapy, and recurrence-free survival (RFS) of patients with rhTSH plus 3.7 GBq versus those with THW plus 5.55 GBq in 253 DTC patients with T4 or N1b disease. There were no differences in the TSH-stimulated thyroglobulin level, rate of incomplete response after initial treatment, or the RFS between the two treatment strategies. However, thyroid bed uptake on follow-up diagnostic RAI whole-body scanning (WBS) was more frequently observed in the group treated with rhTSH plus 3.7 GBq than in the group with THW plus 5.55 GBq. Adjuvant RAI therapy with rhTSH plus 3.7 GBq had comparable results in the absence of persistent tumor, compared with that with THW plus 5.55 GBq. Although thyroid bed uptake was more frequently observed, rhTSH plus 3.7 GBq may be used instead of THW plus 5.55 GBq for adjuvant RAI therapy in patients with T4 or N1b disease. |
| doi_str_mv | 10.1038/s41598-019-42083-3 |
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This study was a retrospective study comparing ablation success rate, response to initial therapy, and recurrence-free survival (RFS) of patients with rhTSH plus 3.7 GBq versus those with THW plus 5.55 GBq in 253 DTC patients with T4 or N1b disease. There were no differences in the TSH-stimulated thyroglobulin level, rate of incomplete response after initial treatment, or the RFS between the two treatment strategies. However, thyroid bed uptake on follow-up diagnostic RAI whole-body scanning (WBS) was more frequently observed in the group treated with rhTSH plus 3.7 GBq than in the group with THW plus 5.55 GBq. Adjuvant RAI therapy with rhTSH plus 3.7 GBq had comparable results in the absence of persistent tumor, compared with that with THW plus 5.55 GBq. Although thyroid bed uptake was more frequently observed, rhTSH plus 3.7 GBq may be used instead of THW plus 5.55 GBq for adjuvant RAI therapy in patients with T4 or N1b disease.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-42083-3</identifier><identifier>PMID: 30944403</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59 ; 631/67/1059/485 ; 631/67/1459/1843 ; Cell Differentiation - radiation effects ; Combined Modality Therapy - methods ; Disease-Free Survival ; Female ; Humanities and Social Sciences ; Humans ; Iodine ; Iodine radioisotopes ; Iodine Radioisotopes - therapeutic use ; Male ; Middle Aged ; multidisciplinary ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - radiotherapy ; Neoplasm Staging - methods ; Patients ; Recombinant Proteins - metabolism ; Retrospective Studies ; Science ; Science (multidisciplinary) ; Thyroglobulin ; Thyroglobulin - metabolism ; Thyroid ; Thyroid cancer ; Thyroid Gland - metabolism ; Thyroid Gland - pathology ; Thyroid Gland - radiation effects ; Thyroid Hormones - metabolism ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - radiotherapy ; Thyroid-stimulating hormone ; Thyrotropin - metabolism ; Thyroxine ; Whole Body Imaging - methods</subject><ispartof>Scientific reports, 2019-04, Vol.9 (1), p.5570-5570, Article 5570</ispartof><rights>The Author(s) 2019</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-deb6ee3e93bba3449128985879de931c796e414f8e05c0e9710408497e09878f3</citedby><cites>FETCH-LOGICAL-c474t-deb6ee3e93bba3449128985879de931c796e414f8e05c0e9710408497e09878f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447529/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447529/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30944403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Shin Young</creatorcontrib><creatorcontrib>Lee, Sang-Woo</creatorcontrib><creatorcontrib>Kim, Wan Wook</creatorcontrib><creatorcontrib>Jung, Jin Hyang</creatorcontrib><creatorcontrib>Lee, Won Kee</creatorcontrib><creatorcontrib>Ahn, Byeong-Cheol</creatorcontrib><creatorcontrib>Lee, Jaetae</creatorcontrib><title>Clinical outcomes of patients with T4 or N1b well-differentiated thyroid cancer after different strategies of adjuvant radioiodine therapy</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>We aimed to determine whether recombinant human thyrotropin (rhTSH) plus 3.7 GBq could replace thyroid hormone withdrawal (THW) plus 5.55 GBq for adjuvant radioactive iodine (RAI) therapy in differentiated thyroid cancer (DTC) patients with T4 or N1b disease. This study was a retrospective study comparing ablation success rate, response to initial therapy, and recurrence-free survival (RFS) of patients with rhTSH plus 3.7 GBq versus those with THW plus 5.55 GBq in 253 DTC patients with T4 or N1b disease. There were no differences in the TSH-stimulated thyroglobulin level, rate of incomplete response after initial treatment, or the RFS between the two treatment strategies. However, thyroid bed uptake on follow-up diagnostic RAI whole-body scanning (WBS) was more frequently observed in the group treated with rhTSH plus 3.7 GBq than in the group with THW plus 5.55 GBq. Adjuvant RAI therapy with rhTSH plus 3.7 GBq had comparable results in the absence of persistent tumor, compared with that with THW plus 5.55 GBq. Although thyroid bed uptake was more frequently observed, rhTSH plus 3.7 GBq may be used instead of THW plus 5.55 GBq for adjuvant RAI therapy in patients with T4 or N1b disease.</description><subject>59</subject><subject>631/67/1059/485</subject><subject>631/67/1459/1843</subject><subject>Cell Differentiation - radiation effects</subject><subject>Combined Modality Therapy - methods</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Iodine</subject><subject>Iodine radioisotopes</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - radiotherapy</subject><subject>Neoplasm Staging - methods</subject><subject>Patients</subject><subject>Recombinant Proteins - 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radiation effects</topic><topic>Combined Modality Therapy - methods</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Iodine</topic><topic>Iodine radioisotopes</topic><topic>Iodine Radioisotopes - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - radiotherapy</topic><topic>Neoplasm Staging - methods</topic><topic>Patients</topic><topic>Recombinant Proteins - metabolism</topic><topic>Retrospective Studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Thyroglobulin</topic><topic>Thyroglobulin - metabolism</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Gland - radiation effects</topic><topic>Thyroid Hormones - metabolism</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - radiotherapy</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyrotropin - metabolism</topic><topic>Thyroxine</topic><topic>Whole Body Imaging - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, Shin Young</creatorcontrib><creatorcontrib>Lee, Sang-Woo</creatorcontrib><creatorcontrib>Kim, Wan Wook</creatorcontrib><creatorcontrib>Jung, Jin Hyang</creatorcontrib><creatorcontrib>Lee, Won Kee</creatorcontrib><creatorcontrib>Ahn, Byeong-Cheol</creatorcontrib><creatorcontrib>Lee, Jaetae</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Shin Young</au><au>Lee, Sang-Woo</au><au>Kim, Wan Wook</au><au>Jung, Jin Hyang</au><au>Lee, Won Kee</au><au>Ahn, Byeong-Cheol</au><au>Lee, Jaetae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical outcomes of patients with T4 or N1b well-differentiated thyroid cancer after different strategies of adjuvant radioiodine therapy</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-04-03</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>5570</spage><epage>5570</epage><pages>5570-5570</pages><artnum>5570</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>We aimed to determine whether recombinant human thyrotropin (rhTSH) plus 3.7 GBq could replace thyroid hormone withdrawal (THW) plus 5.55 GBq for adjuvant radioactive iodine (RAI) therapy in differentiated thyroid cancer (DTC) patients with T4 or N1b disease. This study was a retrospective study comparing ablation success rate, response to initial therapy, and recurrence-free survival (RFS) of patients with rhTSH plus 3.7 GBq versus those with THW plus 5.55 GBq in 253 DTC patients with T4 or N1b disease. There were no differences in the TSH-stimulated thyroglobulin level, rate of incomplete response after initial treatment, or the RFS between the two treatment strategies. However, thyroid bed uptake on follow-up diagnostic RAI whole-body scanning (WBS) was more frequently observed in the group treated with rhTSH plus 3.7 GBq than in the group with THW plus 5.55 GBq. Adjuvant RAI therapy with rhTSH plus 3.7 GBq had comparable results in the absence of persistent tumor, compared with that with THW plus 5.55 GBq. Although thyroid bed uptake was more frequently observed, rhTSH plus 3.7 GBq may be used instead of THW plus 5.55 GBq for adjuvant RAI therapy in patients with T4 or N1b disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30944403</pmid><doi>10.1038/s41598-019-42083-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 59 631/67/1059/485 631/67/1459/1843 Cell Differentiation - radiation effects Combined Modality Therapy - methods Disease-Free Survival Female Humanities and Social Sciences Humans Iodine Iodine radioisotopes Iodine Radioisotopes - therapeutic use Male Middle Aged multidisciplinary Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - radiotherapy Neoplasm Staging - methods Patients Recombinant Proteins - metabolism Retrospective Studies Science Science (multidisciplinary) Thyroglobulin Thyroglobulin - metabolism Thyroid Thyroid cancer Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid Gland - radiation effects Thyroid Hormones - metabolism Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid Neoplasms - radiotherapy Thyroid-stimulating hormone Thyrotropin - metabolism Thyroxine Whole Body Imaging - methods |
| title | Clinical outcomes of patients with T4 or N1b well-differentiated thyroid cancer after different strategies of adjuvant radioiodine therapy |
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