Optimization of the adipose-derived mesenchymal stem cell delivery time for radiation-induced lung fibrosis treatment in rats

The present study attempts to identify the optimal time duration for the administration of Ad-MSCs, in order to maximize its therapeutic benefits, and compare the degree of fibrosis among three different administration time points using the RILF rat model system. Ad-MSCs were delivered to Sprague-Da...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2019-04, Vol.9 (1), p.5589, Article 5589
Hauptverfasser:	Zhang, Yang, Jiang, Xinping, Ren, Liqun
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 631/532/2074 692/699/1785/4039 82 82/51 Adipose Tissue - metabolism Adipose Tissue - pathology Adiposity - physiology Alveoli Animals Cells, Cultured Cytokines Cytokines - metabolism Disease Models, Animal Epithelial cells Fibroblasts Fibrosis Humanities and Social Sciences Inflammation Interleukin 1 Interleukin 10 Interleukin 2 Interleukin 6 Intravenous administration Irradiation Lung - metabolism Lung - pathology Lungs Male Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme multidisciplinary Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Radiation Radiation Injuries - metabolism Radiation Injuries - pathology Radiation Pneumonitis - metabolism Radiation Pneumonitis - pathology Rats Rats, Sprague-Dawley Rodents Science Science (multidisciplinary) Serum levels Stem cells Transforming growth factor-b1 Transplantation Tumor necrosis factor-TNF Tumor necrosis factor-α
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!