Combined MAPK Pathway and HDAC Inhibition Breaks Melanoma

In this issue, Maertens and colleagues demonstrate that HDAC3 inhibition potentiates the effects of MAPK pathway inhibitors in melanoma, including difficult-to-treat - and -driven tumors, with expression serving as a biomarker for responsiveness to the BRAF/MEK/HDAC inhibitor combination. Mechanisti...

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Veröffentlicht in:	Cancer discovery 2019-04, Vol.9 (4), p.469-471
Hauptverfasser:	Lombard, David B, Cierpicki, Tomasz, Grembecka, Jolanta
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Repair - drug effects GTP Phosphohydrolases - genetics Humans Melanoma - genetics Membrane Proteins - genetics Protein Kinase Inhibitors Proto-Oncogene Proteins B-raf - genetics
Online-Zugang:	Volltext
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