Mitochondrial AAA‐ATPase Msp1 detects mislocalized tail‐anchored proteins through a dual‐recognition mechanism

The conserved AAA‐ATPase Msp1 is embedded in the outer mitochondrial membrane and removes mislocalized tail‐anchored (TA) proteins upon dysfunction of the guided entry of tail‐anchored (GET) pathway. It remains unclear how Msp1 recognizes its substrates. Here, we extensively characterize Msp1 and it...

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Veröffentlicht in:	EMBO reports 2019-04, Vol.20 (4), p.n/a
Hauptverfasser:	Li, Lanlan, Zheng, Jing, Wu, Xi, Jiang, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	AAA+ ATPase Adenosine triphosphatase Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Amino Acid Sequence ATAD1 Cytoplasm Domains Electrostatic properties EMBO20 EMBO32 Feature recognition Fungal Proteins Gene Expression Genes, Reporter Hydrophobic and Hydrophilic Interactions Hydrophobic surfaces Hydrophobicity Mitochondria Mitochondria - metabolism mitochondrial protein quality control Models, Molecular Msp1 Protein Binding Protein Conformation Protein Interaction Domains and Motifs Protein Transport Proteins Proteolysis Recombinant Fusion Proteins Residues Sequence Deletion Substrates tail‐anchored proteins
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