Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels

Lymphatic collecting vessels exhibit spontaneous contractions with a pressure-dependent contraction frequency. The initiation of contraction has been proposed to be mediated by the activity of a Ca -activated Cl channel (CaCC). Here, we show that the canonical CaCC Anoctamin 1 (Ano1, TMEM16a) plays...

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Veröffentlicht in:	The Journal of general physiology 2019-04, Vol.151 (4), p.532-554
Hauptverfasser:	Zawieja, Scott D, Castorena, Jorge A, Gui, Peichun, Li, Min, Bulley, Simon A, Jaggar, Jonathan H, Rock, Jason R, Davis, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Calcium Clonal deletion Depolarization Gene deletion Lymphatic system Membrane potential Muscle contraction Pressure Smooth muscle Transgenic mice
Online-Zugang:	Volltext
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