Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension

BMP9 (bone morphogenetic protein 9) is a circulating endothelial quiescence factor with protective effects in pulmonary arterial hypertension (PAH). Loss-of-function mutations in BMP9, its receptors, and downstream effectors have been reported in heritable PAH. To determine how an acquired deficienc...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2019-04, Vol.199 (7), p.891-902
Hauptverfasser:	Nikolic, Ivana, Yung, Lai-Ming, Yang, Peiran, Malhotra, Rajeev, Paskin-Flerlage, Samuel D, Dinter, Teresa, Bocobo, Geoffrey A, Tumelty, Kathleen E, Faugno, Anthony J, Troncone, Luca, McNeil, Megan E, Huang, Xiuli, Coser, Kathryn R, Lai, Carol S C, Upton, Paul D, Goumans, Marie Jose, Zamanian, Roham T, Elliott, C Gregory, Lee, Arthur, Zheng, Wei, Berasi, Stephen P, Huard, Christine, Morrell, Nicholas W, Chung, Raymond T, Channick, Richard W, Roberts, Kari E, Yu, Paul B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers Biomarkers - blood Biomarkers - metabolism Bone Morphogenetic Proteins - metabolism Etiology Female Humans Hypertension, Portal - metabolism Hypertension, Portal - physiopathology Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - physiopathology Hypoxia Kinases Ligands Liver cirrhosis Liver diseases Liver Diseases - metabolism Liver Diseases - physiopathology Male Middle Aged Mutation Original Plasma Proteins Pulmonary arteries Pulmonary hypertension
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