Angiogenesis in cutaneous T-cell lymphoma - proteomic approaches
Neoangiogenesis plays an important role in cutaneous lymphoma pathogenesis. Cutaneous T-cell lymphoma (CTCL) is characterized by the presence of malignant T-cell clones in the skin. Vascular microenvironment of lymphomas accelerates neoangiogenesis through several factors released by tumoral cells:...
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| Veröffentlicht in: | Oncology letters 2019-05, Vol.17 (5), p.4060-4067 |
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| creator | Tanase, Cristiana Popescu, Ionela Daniela Enciu, Ana-Maria Gheorghisan-Galateanu, Ancuta Augustina Codrici, Elena Mihai, Simona Albulescu, Lucian Necula, Laura Albulescu, Radu |
| description | Neoangiogenesis plays an important role in cutaneous lymphoma pathogenesis. Cutaneous T-cell lymphoma (CTCL) is characterized by the presence of malignant T-cell clones in the skin. Vascular microenvironment of lymphomas accelerates neoangiogenesis through several factors released by tumoral cells: VEGF family, bFGF and PIGF. Tumor stroma (fibroblasts, inflammatory and immune cells) also plays a crucial role, by providing additional angiogenic factors. The angiogenic process through the VEGF-VEGFR axis can promote survival, proliferation and metastasis via autocrine mechanisms in cutaneous lymphomas. Microvascular density (MVD) measures the neo-vascularization of cutaneous lymphoma, generated by the response of tumor cells, proangiogenic stromal cells, and benign T/B lymphocytes within the tumor inflammatory infiltrate. Pro-angiogenic proteins have been found to indicate the evolution and prognosis in patients with CTCL. In conclusion, anti-angiogenic therapeutic protocols can target tumor vasculature or malignant tumor cells directly or through a large number of combinations with other drugs. The integration of proteomics into clinical practice based on high-throughput technologies leads to the development of personalized medicine, adapting the specific biomarkers to the application of cancer-type specific individual drug targets. |
| doi_str_mv | 10.3892/ol.2018.9734 |
| format | Article |
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Cutaneous T-cell lymphoma (CTCL) is characterized by the presence of malignant T-cell clones in the skin. Vascular microenvironment of lymphomas accelerates neoangiogenesis through several factors released by tumoral cells: VEGF family, bFGF and PIGF. Tumor stroma (fibroblasts, inflammatory and immune cells) also plays a crucial role, by providing additional angiogenic factors. The angiogenic process through the VEGF-VEGFR axis can promote survival, proliferation and metastasis via autocrine mechanisms in cutaneous lymphomas. Microvascular density (MVD) measures the neo-vascularization of cutaneous lymphoma, generated by the response of tumor cells, proangiogenic stromal cells, and benign T/B lymphocytes within the tumor inflammatory infiltrate. Pro-angiogenic proteins have been found to indicate the evolution and prognosis in patients with CTCL. In conclusion, anti-angiogenic therapeutic protocols can target tumor vasculature or malignant tumor cells directly or through a large number of combinations with other drugs. The integration of proteomics into clinical practice based on high-throughput technologies leads to the development of personalized medicine, adapting the specific biomarkers to the application of cancer-type specific individual drug targets.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2018.9734</identifier><identifier>PMID: 30944599</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Angiogenesis ; Apoptosis ; Cancer therapies ; Cell cycle ; Chemotherapy ; Cytokines ; Diagnosis ; DNA methylation ; Epigenetics ; Gene expression ; Genetic aspects ; Kinases ; Lymphoma ; Medical prognosis ; Mutation ; Neovascularization ; Oncology ; Pathogenesis ; Prognosis ; Review ; Studies ; T cell lymphoma ; Tumors ; Vascular endothelial growth factor</subject><ispartof>Oncology letters, 2019-05, Vol.17 (5), p.4060-4067</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Tanase et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-be97af9aeaa40d69a798cde6c4d721188b738a4f8eba07408027c4b1c90f3c303</citedby><cites>FETCH-LOGICAL-c510t-be97af9aeaa40d69a798cde6c4d721188b738a4f8eba07408027c4b1c90f3c303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444338/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444338/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30944599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanase, Cristiana</creatorcontrib><creatorcontrib>Popescu, Ionela Daniela</creatorcontrib><creatorcontrib>Enciu, Ana-Maria</creatorcontrib><creatorcontrib>Gheorghisan-Galateanu, Ancuta Augustina</creatorcontrib><creatorcontrib>Codrici, Elena</creatorcontrib><creatorcontrib>Mihai, Simona</creatorcontrib><creatorcontrib>Albulescu, Lucian</creatorcontrib><creatorcontrib>Necula, Laura</creatorcontrib><creatorcontrib>Albulescu, Radu</creatorcontrib><title>Angiogenesis in cutaneous T-cell lymphoma - proteomic approaches</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Neoangiogenesis plays an important role in cutaneous lymphoma pathogenesis. Cutaneous T-cell lymphoma (CTCL) is characterized by the presence of malignant T-cell clones in the skin. Vascular microenvironment of lymphomas accelerates neoangiogenesis through several factors released by tumoral cells: VEGF family, bFGF and PIGF. Tumor stroma (fibroblasts, inflammatory and immune cells) also plays a crucial role, by providing additional angiogenic factors. The angiogenic process through the VEGF-VEGFR axis can promote survival, proliferation and metastasis via autocrine mechanisms in cutaneous lymphomas. Microvascular density (MVD) measures the neo-vascularization of cutaneous lymphoma, generated by the response of tumor cells, proangiogenic stromal cells, and benign T/B lymphocytes within the tumor inflammatory infiltrate. Pro-angiogenic proteins have been found to indicate the evolution and prognosis in patients with CTCL. In conclusion, anti-angiogenic therapeutic protocols can target tumor vasculature or malignant tumor cells directly or through a large number of combinations with other drugs. The integration of proteomics into clinical practice based on high-throughput technologies leads to the development of personalized medicine, adapting the specific biomarkers to the application of cancer-type specific individual drug targets.</description><subject>Angiogenesis</subject><subject>Apoptosis</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Chemotherapy</subject><subject>Cytokines</subject><subject>Diagnosis</subject><subject>DNA methylation</subject><subject>Epigenetics</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Kinases</subject><subject>Lymphoma</subject><subject>Medical prognosis</subject><subject>Mutation</subject><subject>Neovascularization</subject><subject>Oncology</subject><subject>Pathogenesis</subject><subject>Prognosis</subject><subject>Review</subject><subject>Studies</subject><subject>T cell lymphoma</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk1r3DAQhkVpaUKaW8_FUCg91Bt92ZIupUto2kIgl-QsZHm8VpAl17IL-feV2WSTLZUOGqRnXs0ML0LvCd4wqehF9BuKidwowfgrdEqEoiXBkr4-xIKfoPOU7nFeVU2krN-iE4YV55VSp-jbNuxc3EGA5FLhQmGX2QSISypuSwveF_5hGPs4mKIsxinOEAdnCzPm2Nge0jv0pjM-wfnjeYburr7fXv4sr29-_LrcXpe2InguG1DCdMqAMRy3tTJCSdtCbXkrKMllNYJJwzsJjck1Y4mpsLwhVuGOWYbZGfq61x2XZoDWQpgn4_U4ucFMDzoap49fguv1Lv7RNeecMZkFPj8KTPH3AmnWg0trh_t2NaWYEVaJmmT04z_ofVymkNvLFMFUclGxZ2pnPGgXupj_tauo3laSKaV4XWVq8x8q7xbyIGOAzuX7o4RPLxJ6MH7uU_TL7GJIx-CXPWinmNIE3WEYBOvVHTp6vbpDr-7I-IeXAzzAT15gfwEODbLi</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Tanase, Cristiana</creator><creator>Popescu, Ionela Daniela</creator><creator>Enciu, Ana-Maria</creator><creator>Gheorghisan-Galateanu, Ancuta Augustina</creator><creator>Codrici, Elena</creator><creator>Mihai, Simona</creator><creator>Albulescu, Lucian</creator><creator>Necula, Laura</creator><creator>Albulescu, Radu</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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Cutaneous T-cell lymphoma (CTCL) is characterized by the presence of malignant T-cell clones in the skin. Vascular microenvironment of lymphomas accelerates neoangiogenesis through several factors released by tumoral cells: VEGF family, bFGF and PIGF. Tumor stroma (fibroblasts, inflammatory and immune cells) also plays a crucial role, by providing additional angiogenic factors. The angiogenic process through the VEGF-VEGFR axis can promote survival, proliferation and metastasis via autocrine mechanisms in cutaneous lymphomas. Microvascular density (MVD) measures the neo-vascularization of cutaneous lymphoma, generated by the response of tumor cells, proangiogenic stromal cells, and benign T/B lymphocytes within the tumor inflammatory infiltrate. Pro-angiogenic proteins have been found to indicate the evolution and prognosis in patients with CTCL. In conclusion, anti-angiogenic therapeutic protocols can target tumor vasculature or malignant tumor cells directly or through a large number of combinations with other drugs. The integration of proteomics into clinical practice based on high-throughput technologies leads to the development of personalized medicine, adapting the specific biomarkers to the application of cancer-type specific individual drug targets.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30944599</pmid><doi>10.3892/ol.2018.9734</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Angiogenesis Apoptosis Cancer therapies Cell cycle Chemotherapy Cytokines Diagnosis DNA methylation Epigenetics Gene expression Genetic aspects Kinases Lymphoma Medical prognosis Mutation Neovascularization Oncology Pathogenesis Prognosis Review Studies T cell lymphoma Tumors Vascular endothelial growth factor |
| title | Angiogenesis in cutaneous T-cell lymphoma - proteomic approaches |
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