Comparative Evaluation of 68Ga-Citrate PET/CT and 18F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. This study aims to predict the di...
Gespeichert in:
| Veröffentlicht in: | Contrast media and molecular imaging 2019-01, Vol.2019 (2019), p.1-8 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8 |
|---|---|
| container_issue | 2019 |
| container_start_page | 1 |
| container_title | Contrast media and molecular imaging |
| container_volume | 2019 |
| creator | Liu, Lin Tang, Dan Xu, Tingting Cai, Liang Wang, Zi Chen, Yue |
| description | Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. This study aims to predict the diagnostic value of 68Ga-citrate and 18F-FDG PET/CT in RA by comparing and analyzing the value of 68Ga-citrate and 18F-FDG PET/CT for diagnosing type II collagen-induced arthritis (CIA) in rats. Some CIA models were established. Normal rats were selected as the control group, and 23 days and 40 days were selected as the early and late time points of arthritis, respectively. The semiquantitative analysis of CIA rats was carried out with 68Ga-citrate PET/CT and 18F-FDG PET/CT, and the ratio of the maximum standardized uptake (SUVmax) values in the regions of interest (ROIs) of the hind foot ankle joint and thigh muscle was calculated and statistically analyzed. The distribution of CIA rats in vivo at the 68Ga-citrate 90 min time point was studied, and the ankle tissues were evaluated with hematoxylin and eosin (HE) staining. 68Ga-citrate PET/CT is obviously superior to 18F-FDG PET/CT for CIA imaging, and the statistical results show that the difference between the two examination methods is statistically significant (P |
| doi_str_mv | 10.1155/2019/2353658 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6444231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2213915963</sourcerecordid><originalsourceid>FETCH-LOGICAL-e2138-b81296fed8c98f40ce74bca0273f8a859ea80ac279d03dbaa5f9c28efaf474a03</originalsourceid><addsrcrecordid>eNpdkc1r20AQxZfS0KRpbz2XhV4CQfF-Sdq9FIJiu4ZASnHPy1ga2RvkXVcrueTUfz1r7KY0pxlmfjO8xyPkE2c3nOf5RDBuJkLmssj1G3KRRnmmJC_fvvTMnJP3MT4yppQ08h05l5zxXAt1Qf5UYbuDHga3RzrdQzemNngaWlroOWSVG9IS6ffpclItKfiGcj3LZnfzvyPn6bBBeudg7UN08XC6fNohXSxoFboO1uizhW_GGht62w-b3g2JSmc_YIgfyFkLXcSPp3pJfs6my-pbdv8wX1S39xkKLnW20lyYosVG10a3itVYqlUNTJSy1aBzg6AZ1KI0DZPNCiBvTS00ttCqUgGTl-Tr8e9uXG2xqdEnX53d9W4L_ZMN4Oz_G-82dh32tlBKCcnTg6vTgz78GjEOdutijcmfxzBGK5JOw3NTyIR-eYU-hrH3yV6iGCtYIfVB0fWR2jjfwG_3ooUzewjWHoK1p2AT_flIY2KSrX80l4yXpXwGypSbqw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2200606380</pqid></control><display><type>article</type><title>Comparative Evaluation of 68Ga-Citrate PET/CT and 18F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats</title><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Liu, Lin ; Tang, Dan ; Xu, Tingting ; Cai, Liang ; Wang, Zi ; Chen, Yue</creator><contributor>Roivainen, Anne ; Anne Roivainen</contributor><creatorcontrib>Liu, Lin ; Tang, Dan ; Xu, Tingting ; Cai, Liang ; Wang, Zi ; Chen, Yue ; Roivainen, Anne ; Anne Roivainen</creatorcontrib><description>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. This study aims to predict the diagnostic value of 68Ga-citrate and 18F-FDG PET/CT in RA by comparing and analyzing the value of 68Ga-citrate and 18F-FDG PET/CT for diagnosing type II collagen-induced arthritis (CIA) in rats. Some CIA models were established. Normal rats were selected as the control group, and 23 days and 40 days were selected as the early and late time points of arthritis, respectively. The semiquantitative analysis of CIA rats was carried out with 68Ga-citrate PET/CT and 18F-FDG PET/CT, and the ratio of the maximum standardized uptake (SUVmax) values in the regions of interest (ROIs) of the hind foot ankle joint and thigh muscle was calculated and statistically analyzed. The distribution of CIA rats in vivo at the 68Ga-citrate 90 min time point was studied, and the ankle tissues were evaluated with hematoxylin and eosin (HE) staining. 68Ga-citrate PET/CT is obviously superior to 18F-FDG PET/CT for CIA imaging, and the statistical results show that the difference between the two examination methods is statistically significant (P<0.001). The uptake of these two radiopharmaceuticals showed the same trend in arthritis rats with different scores. The distribution of 68Ga-citrate at 90 min is consistent with the trend shown by 68Ga-citrate PET/CT. 68Ga-citrate PET/CT can reflect the inflammatory activity of affected joints in CIA rats earlier and more sensitively than 18F-FDG PET/CT, and this imaging advantage continues until the later stage of inflammation. Therefore, 68Ga-citrate PET/CT is worthy of further promotion and application in the clinical diagnosis of RA.</description><identifier>ISSN: 1555-4309</identifier><identifier>EISSN: 1555-4317</identifier><identifier>DOI: 10.1155/2019/2353658</identifier><identifier>PMID: 31015824</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Ankle ; Arthritis ; Autoimmune diseases ; Chromatography ; Citric acid ; Collagen ; Collagen (type II) ; Computed tomography ; Diagnosis ; Diagnostic systems ; Disease ; Drug dosages ; Fluorine isotopes ; Government agencies ; Inflammation ; Joint diseases ; Medical imaging ; Muscles ; NMR ; Nuclear magnetic resonance ; Nuclear medicine ; Positron emission ; Positron emission tomography ; Rheumatic diseases ; Rheumatism ; Rheumatoid arthritis ; Statistical analysis ; Statistical methods ; Synovitis ; Thigh ; Tomography ; Ultrasonic imaging</subject><ispartof>Contrast media and molecular imaging, 2019-01, Vol.2019 (2019), p.1-8</ispartof><rights>Copyright © 2019 Zi Wang et al.</rights><rights>Copyright © 2019 Zi Wang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Zi Wang et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-8508-0027 ; 0000-0003-4088-7649</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444231/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444231/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids></links><search><contributor>Roivainen, Anne</contributor><contributor>Anne Roivainen</contributor><creatorcontrib>Liu, Lin</creatorcontrib><creatorcontrib>Tang, Dan</creatorcontrib><creatorcontrib>Xu, Tingting</creatorcontrib><creatorcontrib>Cai, Liang</creatorcontrib><creatorcontrib>Wang, Zi</creatorcontrib><creatorcontrib>Chen, Yue</creatorcontrib><title>Comparative Evaluation of 68Ga-Citrate PET/CT and 18F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats</title><title>Contrast media and molecular imaging</title><description>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. This study aims to predict the diagnostic value of 68Ga-citrate and 18F-FDG PET/CT in RA by comparing and analyzing the value of 68Ga-citrate and 18F-FDG PET/CT for diagnosing type II collagen-induced arthritis (CIA) in rats. Some CIA models were established. Normal rats were selected as the control group, and 23 days and 40 days were selected as the early and late time points of arthritis, respectively. The semiquantitative analysis of CIA rats was carried out with 68Ga-citrate PET/CT and 18F-FDG PET/CT, and the ratio of the maximum standardized uptake (SUVmax) values in the regions of interest (ROIs) of the hind foot ankle joint and thigh muscle was calculated and statistically analyzed. The distribution of CIA rats in vivo at the 68Ga-citrate 90 min time point was studied, and the ankle tissues were evaluated with hematoxylin and eosin (HE) staining. 68Ga-citrate PET/CT is obviously superior to 18F-FDG PET/CT for CIA imaging, and the statistical results show that the difference between the two examination methods is statistically significant (P<0.001). The uptake of these two radiopharmaceuticals showed the same trend in arthritis rats with different scores. The distribution of 68Ga-citrate at 90 min is consistent with the trend shown by 68Ga-citrate PET/CT. 68Ga-citrate PET/CT can reflect the inflammatory activity of affected joints in CIA rats earlier and more sensitively than 18F-FDG PET/CT, and this imaging advantage continues until the later stage of inflammation. Therefore, 68Ga-citrate PET/CT is worthy of further promotion and application in the clinical diagnosis of RA.</description><subject>Ankle</subject><subject>Arthritis</subject><subject>Autoimmune diseases</subject><subject>Chromatography</subject><subject>Citric acid</subject><subject>Collagen</subject><subject>Collagen (type II)</subject><subject>Computed tomography</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Disease</subject><subject>Drug dosages</subject><subject>Fluorine isotopes</subject><subject>Government agencies</subject><subject>Inflammation</subject><subject>Joint diseases</subject><subject>Medical imaging</subject><subject>Muscles</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclear medicine</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Rheumatic diseases</subject><subject>Rheumatism</subject><subject>Rheumatoid arthritis</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Synovitis</subject><subject>Thigh</subject><subject>Tomography</subject><subject>Ultrasonic imaging</subject><issn>1555-4309</issn><issn>1555-4317</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkc1r20AQxZfS0KRpbz2XhV4CQfF-Sdq9FIJiu4ZASnHPy1ga2RvkXVcrueTUfz1r7KY0pxlmfjO8xyPkE2c3nOf5RDBuJkLmssj1G3KRRnmmJC_fvvTMnJP3MT4yppQ08h05l5zxXAt1Qf5UYbuDHga3RzrdQzemNngaWlroOWSVG9IS6ffpclItKfiGcj3LZnfzvyPn6bBBeudg7UN08XC6fNohXSxoFboO1uizhW_GGht62w-b3g2JSmc_YIgfyFkLXcSPp3pJfs6my-pbdv8wX1S39xkKLnW20lyYosVG10a3itVYqlUNTJSy1aBzg6AZ1KI0DZPNCiBvTS00ttCqUgGTl-Tr8e9uXG2xqdEnX53d9W4L_ZMN4Oz_G-82dh32tlBKCcnTg6vTgz78GjEOdutijcmfxzBGK5JOw3NTyIR-eYU-hrH3yV6iGCtYIfVB0fWR2jjfwG_3ooUzewjWHoK1p2AT_flIY2KSrX80l4yXpXwGypSbqw</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Liu, Lin</creator><creator>Tang, Dan</creator><creator>Xu, Tingting</creator><creator>Cai, Liang</creator><creator>Wang, Zi</creator><creator>Chen, Yue</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8508-0027</orcidid><orcidid>https://orcid.org/0000-0003-4088-7649</orcidid></search><sort><creationdate>20190101</creationdate><title>Comparative Evaluation of 68Ga-Citrate PET/CT and 18F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats</title><author>Liu, Lin ; Tang, Dan ; Xu, Tingting ; Cai, Liang ; Wang, Zi ; Chen, Yue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e2138-b81296fed8c98f40ce74bca0273f8a859ea80ac279d03dbaa5f9c28efaf474a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Ankle</topic><topic>Arthritis</topic><topic>Autoimmune diseases</topic><topic>Chromatography</topic><topic>Citric acid</topic><topic>Collagen</topic><topic>Collagen (type II)</topic><topic>Computed tomography</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Disease</topic><topic>Drug dosages</topic><topic>Fluorine isotopes</topic><topic>Government agencies</topic><topic>Inflammation</topic><topic>Joint diseases</topic><topic>Medical imaging</topic><topic>Muscles</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nuclear medicine</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Rheumatic diseases</topic><topic>Rheumatism</topic><topic>Rheumatoid arthritis</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Synovitis</topic><topic>Thigh</topic><topic>Tomography</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Lin</creatorcontrib><creatorcontrib>Tang, Dan</creatorcontrib><creatorcontrib>Xu, Tingting</creatorcontrib><creatorcontrib>Cai, Liang</creatorcontrib><creatorcontrib>Wang, Zi</creatorcontrib><creatorcontrib>Chen, Yue</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Contrast media and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Lin</au><au>Tang, Dan</au><au>Xu, Tingting</au><au>Cai, Liang</au><au>Wang, Zi</au><au>Chen, Yue</au><au>Roivainen, Anne</au><au>Anne Roivainen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Evaluation of 68Ga-Citrate PET/CT and 18F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats</atitle><jtitle>Contrast media and molecular imaging</jtitle><date>2019-01-01</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1555-4309</issn><eissn>1555-4317</eissn><abstract>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. This study aims to predict the diagnostic value of 68Ga-citrate and 18F-FDG PET/CT in RA by comparing and analyzing the value of 68Ga-citrate and 18F-FDG PET/CT for diagnosing type II collagen-induced arthritis (CIA) in rats. Some CIA models were established. Normal rats were selected as the control group, and 23 days and 40 days were selected as the early and late time points of arthritis, respectively. The semiquantitative analysis of CIA rats was carried out with 68Ga-citrate PET/CT and 18F-FDG PET/CT, and the ratio of the maximum standardized uptake (SUVmax) values in the regions of interest (ROIs) of the hind foot ankle joint and thigh muscle was calculated and statistically analyzed. The distribution of CIA rats in vivo at the 68Ga-citrate 90 min time point was studied, and the ankle tissues were evaluated with hematoxylin and eosin (HE) staining. 68Ga-citrate PET/CT is obviously superior to 18F-FDG PET/CT for CIA imaging, and the statistical results show that the difference between the two examination methods is statistically significant (P<0.001). The uptake of these two radiopharmaceuticals showed the same trend in arthritis rats with different scores. The distribution of 68Ga-citrate at 90 min is consistent with the trend shown by 68Ga-citrate PET/CT. 68Ga-citrate PET/CT can reflect the inflammatory activity of affected joints in CIA rats earlier and more sensitively than 18F-FDG PET/CT, and this imaging advantage continues until the later stage of inflammation. Therefore, 68Ga-citrate PET/CT is worthy of further promotion and application in the clinical diagnosis of RA.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31015824</pmid><doi>10.1155/2019/2353658</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8508-0027</orcidid><orcidid>https://orcid.org/0000-0003-4088-7649</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1555-4309 |
| ispartof | Contrast media and molecular imaging, 2019-01, Vol.2019 (2019), p.1-8 |
| issn | 1555-4309 1555-4317 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6444231 |
| source | PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Ankle Arthritis Autoimmune diseases Chromatography Citric acid Collagen Collagen (type II) Computed tomography Diagnosis Diagnostic systems Disease Drug dosages Fluorine isotopes Government agencies Inflammation Joint diseases Medical imaging Muscles NMR Nuclear magnetic resonance Nuclear medicine Positron emission Positron emission tomography Rheumatic diseases Rheumatism Rheumatoid arthritis Statistical analysis Statistical methods Synovitis Thigh Tomography Ultrasonic imaging |
| title | Comparative Evaluation of 68Ga-Citrate PET/CT and 18F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T21%3A31%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20Evaluation%20of%2068Ga-Citrate%20PET/CT%20and%2018F-FDG%20PET/CT%20in%20the%20Diagnosis%20of%20Type%20II%20Collagen-Induced%20Arthritis%20in%20Rats&rft.jtitle=Contrast%20media%20and%20molecular%20imaging&rft.au=Liu,%20Lin&rft.date=2019-01-01&rft.volume=2019&rft.issue=2019&rft.spage=1&rft.epage=8&rft.pages=1-8&rft.issn=1555-4309&rft.eissn=1555-4317&rft_id=info:doi/10.1155/2019/2353658&rft_dat=%3Cproquest_pubme%3E2213915963%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2200606380&rft_id=info:pmid/31015824&rfr_iscdi=true |