Crohn's Disease with Mesalazine Allergy that Was Difficult to Differentiate from Comorbid Ulcerative Colitis
An 18-year-old man diagnosed with ileocolonic Crohn's disease with circumferential strictures of the ascending colon started treatment with mesalazine and subsequently underwent right hemicolectomy. After surgery, the patient was started on adalimumab, and the clinical course was favorable. Nin...
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| Veröffentlicht in: | Internal Medicine 2019/03/01, Vol.58(5), pp.649-654 |
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| creator | Tsuboi, Rumiko Matsumoto, Satohiro Miyatani, Hiroyuki Mashima, Hirosato |
| description | An 18-year-old man diagnosed with ileocolonic Crohn's disease with circumferential strictures of the ascending colon started treatment with mesalazine and subsequently underwent right hemicolectomy. After surgery, the patient was started on adalimumab, and the clinical course was favorable. Nine months postoperatively, colonoscopy revealed granular mucosa with circumferential and continuous involvement from the transverse colon down to the rectum, findings which resembled ulcerative colitis. Mesalazine allergy was suspected, and the inflammatory findings resolved after discontinuing mesalazine. In patients of inflammatory bowel disease receiving mesalazine with an atypical clinical course, the possibility of mesalazine allergy must be borne in mind. |
| doi_str_mv | 10.2169/internalmedicine.1607-18 |
| format | Article |
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After surgery, the patient was started on adalimumab, and the clinical course was favorable. Nine months postoperatively, colonoscopy revealed granular mucosa with circumferential and continuous involvement from the transverse colon down to the rectum, findings which resembled ulcerative colitis. Mesalazine allergy was suspected, and the inflammatory findings resolved after discontinuing mesalazine. In patients of inflammatory bowel disease receiving mesalazine with an atypical clinical course, the possibility of mesalazine allergy must be borne in mind.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.1607-18</identifier><identifier>PMID: 30333413</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Allergies ; Case Report ; Colon ; Crohn's disease ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Internal medicine ; Intestine ; mesalazine allergy ; Monoclonal antibodies ; Mucosa ; Patients ; Rectum ; Stricture ; Surgery ; Ulcerative colitis</subject><ispartof>Internal Medicine, 2019/03/01, Vol.58(5), pp.649-654</ispartof><rights>2019 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><rights>Copyright © 2019 by The Japanese Society of Internal Medicine 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-bdacfb6c67e40525b018555741aec54799af928356a592763da2ea73607538b63</citedby><cites>FETCH-LOGICAL-c609t-bdacfb6c67e40525b018555741aec54799af928356a592763da2ea73607538b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443567/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443567/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1881,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30333413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuboi, Rumiko</creatorcontrib><creatorcontrib>Matsumoto, Satohiro</creatorcontrib><creatorcontrib>Miyatani, Hiroyuki</creatorcontrib><creatorcontrib>Mashima, Hirosato</creatorcontrib><title>Crohn's Disease with Mesalazine Allergy that Was Difficult to Differentiate from Comorbid Ulcerative Colitis</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>An 18-year-old man diagnosed with ileocolonic Crohn's disease with circumferential strictures of the ascending colon started treatment with mesalazine and subsequently underwent right hemicolectomy. After surgery, the patient was started on adalimumab, and the clinical course was favorable. Nine months postoperatively, colonoscopy revealed granular mucosa with circumferential and continuous involvement from the transverse colon down to the rectum, findings which resembled ulcerative colitis. Mesalazine allergy was suspected, and the inflammatory findings resolved after discontinuing mesalazine. In patients of inflammatory bowel disease receiving mesalazine with an atypical clinical course, the possibility of mesalazine allergy must be borne in mind.</description><subject>Allergies</subject><subject>Case Report</subject><subject>Colon</subject><subject>Crohn's disease</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Internal medicine</subject><subject>Intestine</subject><subject>mesalazine allergy</subject><subject>Monoclonal antibodies</subject><subject>Mucosa</subject><subject>Patients</subject><subject>Rectum</subject><subject>Stricture</subject><subject>Surgery</subject><subject>Ulcerative colitis</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNplkU9v1DAQxSMEokvhKyBLHOCSEttxYl-QquWvVOBCxdGaeCcbr5y42E5R--nrdJcVlMtYtn9-8zyvKAitzhht1Fs7JQwTuBE31tgJz2hTtSWVj4oV5bUqW8bF42JVKSpLlstJ8SzGXVVx2Sr2tDjhFee8pnxVuHXww_Q6kvc2IkQkv20ayFeM4OA2K5Nz5zBsb0gaIJGfsIB9b83sEkn-foMBp2QhIemDH8najz50dkMuncEAyV5jPnM22fi8eNKDi_jisJ4Wlx8__Fh_Li--f_qyPr8oTVOpVHYbMH3XmKbFuhJMdBWVQoi2poBG1K1S0CsmuWhAKNY2fAMMoeV5BoLLruGnxbu97tXc5RGZ7C-A01fBjhButAer_72Z7KC3_lo3dZ1V2yzw5iAQ_K8ZY9KjjQadgwn9HDWjjAmpKJUZffUA3fl5ySZTrG6yT6FUpuSeMsHHGLA_mqGVXiLVDyPVS6T6vsHLvz9zfPgnwwx82wO7mGCLRwBCssbh_8pCarGUQ4cjaAYIGid-B0N1wIU</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Tsuboi, Rumiko</creator><creator>Matsumoto, Satohiro</creator><creator>Miyatani, Hiroyuki</creator><creator>Mashima, Hirosato</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190301</creationdate><title>Crohn's Disease with Mesalazine Allergy that Was Difficult to Differentiate from Comorbid Ulcerative Colitis</title><author>Tsuboi, Rumiko ; Matsumoto, Satohiro ; Miyatani, Hiroyuki ; Mashima, Hirosato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-bdacfb6c67e40525b018555741aec54799af928356a592763da2ea73607538b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Allergies</topic><topic>Case Report</topic><topic>Colon</topic><topic>Crohn's disease</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Internal medicine</topic><topic>Intestine</topic><topic>mesalazine allergy</topic><topic>Monoclonal antibodies</topic><topic>Mucosa</topic><topic>Patients</topic><topic>Rectum</topic><topic>Stricture</topic><topic>Surgery</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuboi, Rumiko</creatorcontrib><creatorcontrib>Matsumoto, Satohiro</creatorcontrib><creatorcontrib>Miyatani, Hiroyuki</creatorcontrib><creatorcontrib>Mashima, Hirosato</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuboi, Rumiko</au><au>Matsumoto, Satohiro</au><au>Miyatani, Hiroyuki</au><au>Mashima, Hirosato</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crohn's Disease with Mesalazine Allergy that Was Difficult to Differentiate from Comorbid Ulcerative Colitis</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>58</volume><issue>5</issue><spage>649</spage><epage>654</epage><pages>649-654</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>An 18-year-old man diagnosed with ileocolonic Crohn's disease with circumferential strictures of the ascending colon started treatment with mesalazine and subsequently underwent right hemicolectomy. After surgery, the patient was started on adalimumab, and the clinical course was favorable. Nine months postoperatively, colonoscopy revealed granular mucosa with circumferential and continuous involvement from the transverse colon down to the rectum, findings which resembled ulcerative colitis. Mesalazine allergy was suspected, and the inflammatory findings resolved after discontinuing mesalazine. 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| ispartof | Internal Medicine, 2019/03/01, Vol.58(5), pp.649-654 |
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| source | J-STAGE Free; PubMed Central Open Access; PubMed Central |
| subjects | Allergies Case Report Colon Crohn's disease Inflammatory bowel disease Inflammatory bowel diseases Internal medicine Intestine mesalazine allergy Monoclonal antibodies Mucosa Patients Rectum Stricture Surgery Ulcerative colitis |
| title | Crohn's Disease with Mesalazine Allergy that Was Difficult to Differentiate from Comorbid Ulcerative Colitis |
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