Cortical Hyperintensity on Diffusion-weighted Images as the Presymptomatic Marker of Sporadic Creutzfeldt-Jakob Disease
We herein report a sporadic Creutzfeldt-Jakob disease (sCJD) patient followed from the presymptomatic phase to death. A 67-year-old woman had abnormal hyperintense cortical lesions on diffusion-weighted magnetic resonance imaging (MRI) one year before the onset. The levels of 14-3-3 protein and tota...
Gespeichert in:
| Veröffentlicht in: | Internal Medicine 2019/03/01, Vol.58(5), pp.727-729 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 729 |
|---|---|
| container_issue | 5 |
| container_start_page | 727 |
| container_title | Internal Medicine |
| container_volume | 58 |
| creator | Maeda, Kengo Sugihara, Yoshiko Shiraishi, Tomoyuki Hirai, Akinori Satoh, Katsuya |
| description | We herein report a sporadic Creutzfeldt-Jakob disease (sCJD) patient followed from the presymptomatic phase to death. A 67-year-old woman had abnormal hyperintense cortical lesions on diffusion-weighted magnetic resonance imaging (MRI) one year before the onset. The levels of 14-3-3 protein and total tau protein, and findings from a real-time quaking-induced conversion test were normal at first but became abnormal after disease onset. Although there are four reports of presymptomatic sCJD identified by MRI, this is the first case report in which all three biomarkers had been assessed before and after the disease onset. MRI might be the most sensitive modality for detecting presymptomatic sCJD patients. |
| doi_str_mv | 10.2169/internalmedicine.1155-18 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6443561</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2246926683</sourcerecordid><originalsourceid>FETCH-LOGICAL-c666t-74c642f2754ac1d3f3a2ac0bc055a748a499074ffe580d32c98c35a62bcde99d3</originalsourceid><addsrcrecordid>eNplkUuP0zAURiMEYsrAX0CW2LDJ4GcSb5BQecyg4SEBa-vWuWndSeKO7TAqvx5HLRUMXlwvfO7na5-iIIxecFbpV25MGEboB2yddSNeMKZUyZoHxYIJqcuaC_WwWFDNmpLnclY8iXFLqWhqzR8XZ4KKvLRaFHdLH5Kz0JPL_Q7DHDxGl_bEj-St67opOj-Wd-jWm4QtuRpgjZFAJGmD5GvAuB92yQ-QM8gnCDcYiO_It50PkEcjy4BT-tVh36byI9z4VQ6NCBGfFo866CM-O-7nxY_3774vL8vrLx-ulm-uS1tVVSpraSvJO14rCZa1ohPAwdKVpUpBLRuQWtNadh2qhraCW91YoaDiK9ui1q04L14fcnfTKv-WxTEF6M0uuAHC3nhw5t-T0W3M2v80lZRCVSwHvDwGBH87YUxmcNFi38OIfoqGM86VrqmsM_riHrr106wpU1xWmldVIzLVHCgbfIwBu9MwjJrZrrlv18x2DWty6_O_H3Nq_KMzA58PwDamLOoEwOy4x_-TVWPUXI43nEC7gWBwFL8BZurGRA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2246926683</pqid></control><display><type>article</type><title>Cortical Hyperintensity on Diffusion-weighted Images as the Presymptomatic Marker of Sporadic Creutzfeldt-Jakob Disease</title><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Maeda, Kengo ; Sugihara, Yoshiko ; Shiraishi, Tomoyuki ; Hirai, Akinori ; Satoh, Katsuya</creator><creatorcontrib>Maeda, Kengo ; Sugihara, Yoshiko ; Shiraishi, Tomoyuki ; Hirai, Akinori ; Satoh, Katsuya</creatorcontrib><description>We herein report a sporadic Creutzfeldt-Jakob disease (sCJD) patient followed from the presymptomatic phase to death. A 67-year-old woman had abnormal hyperintense cortical lesions on diffusion-weighted magnetic resonance imaging (MRI) one year before the onset. The levels of 14-3-3 protein and total tau protein, and findings from a real-time quaking-induced conversion test were normal at first but became abnormal after disease onset. Although there are four reports of presymptomatic sCJD identified by MRI, this is the first case report in which all three biomarkers had been assessed before and after the disease onset. MRI might be the most sensitive modality for detecting presymptomatic sCJD patients.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.1155-18</identifier><identifier>PMID: 30333395</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>14-3-3 protein ; Case Report ; Cortex ; Creutzfeldt-Jakob disease ; Diffusion ; Internal medicine ; Lesions ; Magnetic resonance imaging ; MRI ; NMR ; Nuclear magnetic resonance ; presymptomatic ; RT-QuIC ; sporadic Creutzfeldt-Jakob disease ; Tau protein</subject><ispartof>Internal Medicine, 2019/03/01, Vol.58(5), pp.727-729</ispartof><rights>2019 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><rights>Copyright © 2019 by The Japanese Society of Internal Medicine 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c666t-74c642f2754ac1d3f3a2ac0bc055a748a499074ffe580d32c98c35a62bcde99d3</citedby><cites>FETCH-LOGICAL-c666t-74c642f2754ac1d3f3a2ac0bc055a748a499074ffe580d32c98c35a62bcde99d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443561/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443561/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30333395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maeda, Kengo</creatorcontrib><creatorcontrib>Sugihara, Yoshiko</creatorcontrib><creatorcontrib>Shiraishi, Tomoyuki</creatorcontrib><creatorcontrib>Hirai, Akinori</creatorcontrib><creatorcontrib>Satoh, Katsuya</creatorcontrib><title>Cortical Hyperintensity on Diffusion-weighted Images as the Presymptomatic Marker of Sporadic Creutzfeldt-Jakob Disease</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We herein report a sporadic Creutzfeldt-Jakob disease (sCJD) patient followed from the presymptomatic phase to death. A 67-year-old woman had abnormal hyperintense cortical lesions on diffusion-weighted magnetic resonance imaging (MRI) one year before the onset. The levels of 14-3-3 protein and total tau protein, and findings from a real-time quaking-induced conversion test were normal at first but became abnormal after disease onset. Although there are four reports of presymptomatic sCJD identified by MRI, this is the first case report in which all three biomarkers had been assessed before and after the disease onset. MRI might be the most sensitive modality for detecting presymptomatic sCJD patients.</description><subject>14-3-3 protein</subject><subject>Case Report</subject><subject>Cortex</subject><subject>Creutzfeldt-Jakob disease</subject><subject>Diffusion</subject><subject>Internal medicine</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>MRI</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>presymptomatic</subject><subject>RT-QuIC</subject><subject>sporadic Creutzfeldt-Jakob disease</subject><subject>Tau protein</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNplkUuP0zAURiMEYsrAX0CW2LDJ4GcSb5BQecyg4SEBa-vWuWndSeKO7TAqvx5HLRUMXlwvfO7na5-iIIxecFbpV25MGEboB2yddSNeMKZUyZoHxYIJqcuaC_WwWFDNmpLnclY8iXFLqWhqzR8XZ4KKvLRaFHdLH5Kz0JPL_Q7DHDxGl_bEj-St67opOj-Wd-jWm4QtuRpgjZFAJGmD5GvAuB92yQ-QM8gnCDcYiO_It50PkEcjy4BT-tVh36byI9z4VQ6NCBGfFo866CM-O-7nxY_3774vL8vrLx-ulm-uS1tVVSpraSvJO14rCZa1ohPAwdKVpUpBLRuQWtNadh2qhraCW91YoaDiK9ui1q04L14fcnfTKv-WxTEF6M0uuAHC3nhw5t-T0W3M2v80lZRCVSwHvDwGBH87YUxmcNFi38OIfoqGM86VrqmsM_riHrr106wpU1xWmldVIzLVHCgbfIwBu9MwjJrZrrlv18x2DWty6_O_H3Nq_KMzA58PwDamLOoEwOy4x_-TVWPUXI43nEC7gWBwFL8BZurGRA</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Maeda, Kengo</creator><creator>Sugihara, Yoshiko</creator><creator>Shiraishi, Tomoyuki</creator><creator>Hirai, Akinori</creator><creator>Satoh, Katsuya</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190301</creationdate><title>Cortical Hyperintensity on Diffusion-weighted Images as the Presymptomatic Marker of Sporadic Creutzfeldt-Jakob Disease</title><author>Maeda, Kengo ; Sugihara, Yoshiko ; Shiraishi, Tomoyuki ; Hirai, Akinori ; Satoh, Katsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c666t-74c642f2754ac1d3f3a2ac0bc055a748a499074ffe580d32c98c35a62bcde99d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>14-3-3 protein</topic><topic>Case Report</topic><topic>Cortex</topic><topic>Creutzfeldt-Jakob disease</topic><topic>Diffusion</topic><topic>Internal medicine</topic><topic>Lesions</topic><topic>Magnetic resonance imaging</topic><topic>MRI</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>presymptomatic</topic><topic>RT-QuIC</topic><topic>sporadic Creutzfeldt-Jakob disease</topic><topic>Tau protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maeda, Kengo</creatorcontrib><creatorcontrib>Sugihara, Yoshiko</creatorcontrib><creatorcontrib>Shiraishi, Tomoyuki</creatorcontrib><creatorcontrib>Hirai, Akinori</creatorcontrib><creatorcontrib>Satoh, Katsuya</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maeda, Kengo</au><au>Sugihara, Yoshiko</au><au>Shiraishi, Tomoyuki</au><au>Hirai, Akinori</au><au>Satoh, Katsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical Hyperintensity on Diffusion-weighted Images as the Presymptomatic Marker of Sporadic Creutzfeldt-Jakob Disease</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>58</volume><issue>5</issue><spage>727</spage><epage>729</epage><pages>727-729</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>We herein report a sporadic Creutzfeldt-Jakob disease (sCJD) patient followed from the presymptomatic phase to death. A 67-year-old woman had abnormal hyperintense cortical lesions on diffusion-weighted magnetic resonance imaging (MRI) one year before the onset. The levels of 14-3-3 protein and total tau protein, and findings from a real-time quaking-induced conversion test were normal at first but became abnormal after disease onset. Although there are four reports of presymptomatic sCJD identified by MRI, this is the first case report in which all three biomarkers had been assessed before and after the disease onset. MRI might be the most sensitive modality for detecting presymptomatic sCJD patients.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>30333395</pmid><doi>10.2169/internalmedicine.1155-18</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-2918 |
| ispartof | Internal Medicine, 2019/03/01, Vol.58(5), pp.727-729 |
| issn | 0918-2918 1349-7235 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6443561 |
| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; PubMed Central; PubMed Central Open Access |
| subjects | 14-3-3 protein Case Report Cortex Creutzfeldt-Jakob disease Diffusion Internal medicine Lesions Magnetic resonance imaging MRI NMR Nuclear magnetic resonance presymptomatic RT-QuIC sporadic Creutzfeldt-Jakob disease Tau protein |
| title | Cortical Hyperintensity on Diffusion-weighted Images as the Presymptomatic Marker of Sporadic Creutzfeldt-Jakob Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T09%3A26%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cortical%20Hyperintensity%20on%20Diffusion-weighted%20Images%20as%20the%20Presymptomatic%20Marker%20of%20Sporadic%20Creutzfeldt-Jakob%20Disease&rft.jtitle=Internal%20Medicine&rft.au=Maeda,%20Kengo&rft.date=2019-03-01&rft.volume=58&rft.issue=5&rft.spage=727&rft.epage=729&rft.pages=727-729&rft.issn=0918-2918&rft.eissn=1349-7235&rft_id=info:doi/10.2169/internalmedicine.1155-18&rft_dat=%3Cproquest_pubme%3E2246926683%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2246926683&rft_id=info:pmid/30333395&rfr_iscdi=true |