Rapidly Progressive Multiple Cavity Formation in Necrotizing Pneumonia Caused by Community-acquired Methicillin-resistant Staphylococcus aureus Positive for the Panton-Valentine Leucocidin Gene
A 66-year-old man was transferred to our hospital for pneumonia that was resistant to sulbactam/ampicillin and levofloxacin therapy. Chest computed tomography showed the rapidly progressive formation of multiple cavities. Methicillin-resistant Staphylococcus aureus (MRSA) was isolated, and the patie...
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| Veröffentlicht in: | Internal Medicine 2019/03/01, Vol.58(5), pp.685-691 |
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| creator | Takigawa, Yuki Fujiwara, Keiichi Saito, Takashi Nakasuka, Takamasa Ozeki, Taichi Okawa, Sachi Takada, Kenji Iwamoto, Yoshitaka Kayatani, Hiroe Minami, Daisuke Sato, Ken Nagao, Miki Shibayama, Takuo |
| description | A 66-year-old man was transferred to our hospital for pneumonia that was resistant to sulbactam/ampicillin and levofloxacin therapy. Chest computed tomography showed the rapidly progressive formation of multiple cavities. Methicillin-resistant Staphylococcus aureus (MRSA) was isolated, and the patient was diagnosed with necrotizing pneumonia caused by community-acquired MRSA (CA-MRSA). The MRSA strain had type IV staphylococcus cassette chromosome mec and genes encoding Panton-Valentine leucocidin (PVL). CA-MRSA necrotizing pneumonia with the PVL gene is rare; only three cases have been previously reported in Japan. We administered anti-MRSA antibiotics and the patient achieved complete clinical and radiological improvement. |
| doi_str_mv | 10.2169/internalmedicine.1454-18 |
| format | Article |
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Chest computed tomography showed the rapidly progressive formation of multiple cavities. Methicillin-resistant Staphylococcus aureus (MRSA) was isolated, and the patient was diagnosed with necrotizing pneumonia caused by community-acquired MRSA (CA-MRSA). The MRSA strain had type IV staphylococcus cassette chromosome mec and genes encoding Panton-Valentine leucocidin (PVL). CA-MRSA necrotizing pneumonia with the PVL gene is rare; only three cases have been previously reported in Japan. We administered anti-MRSA antibiotics and the patient achieved complete clinical and radiological improvement.</description><identifier>ISSN: 0918-2918</identifier><identifier>ISSN: 1349-7235</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.1454-18</identifier><identifier>PMID: 30333405</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged ; Ampicillin ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Bacterial Toxins - genetics ; Case Report ; Community-Acquired Infections - diagnostic imaging ; Community-Acquired Infections - drug therapy ; Community-Acquired Infections - microbiology ; community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) ; Computed tomography ; Drug resistance ; Exotoxins - genetics ; Holes ; Humans ; influenza ; Internal medicine ; Leukocidins - genetics ; Levofloxacin ; Male ; Methicillin ; Methicillin Resistance ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; multiple cavity formation ; necrotizing pneumonia ; Panton-Valentine leukocidine (PVL) gene ; Patients ; Pneumonia ; Pneumonia, Necrotizing - diagnostic imaging ; Pneumonia, Necrotizing - drug therapy ; Pneumonia, Necrotizing - microbiology ; Pneumonia, Staphylococcal - diagnostic imaging ; Pneumonia, Staphylococcal - drug therapy ; Pneumonia, Staphylococcal - microbiology ; Radiography ; Staphylococcus aureus ; Staphylococcus infections ; Sulbactam ; Tomography, X-Ray Computed</subject><ispartof>Internal Medicine, 2019/03/01, Vol.58(5), pp.685-691</ispartof><rights>2019 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><rights>Copyright © 2019 by The Japanese Society of Internal Medicine 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c710t-9be20325e6c1f0b845a0beba190a297589739dc5c241b13b38cd9ba1063bd22f3</citedby><cites>FETCH-LOGICAL-c710t-9be20325e6c1f0b845a0beba190a297589739dc5c241b13b38cd9ba1063bd22f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443543/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443543/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,1877,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30333405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takigawa, Yuki</creatorcontrib><creatorcontrib>Fujiwara, Keiichi</creatorcontrib><creatorcontrib>Saito, Takashi</creatorcontrib><creatorcontrib>Nakasuka, Takamasa</creatorcontrib><creatorcontrib>Ozeki, Taichi</creatorcontrib><creatorcontrib>Okawa, Sachi</creatorcontrib><creatorcontrib>Takada, Kenji</creatorcontrib><creatorcontrib>Iwamoto, Yoshitaka</creatorcontrib><creatorcontrib>Kayatani, Hiroe</creatorcontrib><creatorcontrib>Minami, Daisuke</creatorcontrib><creatorcontrib>Sato, Ken</creatorcontrib><creatorcontrib>Nagao, Miki</creatorcontrib><creatorcontrib>Shibayama, Takuo</creatorcontrib><title>Rapidly Progressive Multiple Cavity Formation in Necrotizing Pneumonia Caused by Community-acquired Methicillin-resistant Staphylococcus aureus Positive for the Panton-Valentine Leucocidin Gene</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 66-year-old man was transferred to our hospital for pneumonia that was resistant to sulbactam/ampicillin and levofloxacin therapy. Chest computed tomography showed the rapidly progressive formation of multiple cavities. Methicillin-resistant Staphylococcus aureus (MRSA) was isolated, and the patient was diagnosed with necrotizing pneumonia caused by community-acquired MRSA (CA-MRSA). The MRSA strain had type IV staphylococcus cassette chromosome mec and genes encoding Panton-Valentine leucocidin (PVL). CA-MRSA necrotizing pneumonia with the PVL gene is rare; only three cases have been previously reported in Japan. We administered anti-MRSA antibiotics and the patient achieved complete clinical and radiological improvement.</description><subject>Aged</subject><subject>Ampicillin</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Bacterial Toxins - genetics</subject><subject>Case Report</subject><subject>Community-Acquired Infections - diagnostic imaging</subject><subject>Community-Acquired Infections - drug therapy</subject><subject>Community-Acquired Infections - microbiology</subject><subject>community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)</subject><subject>Computed tomography</subject><subject>Drug resistance</subject><subject>Exotoxins - genetics</subject><subject>Holes</subject><subject>Humans</subject><subject>influenza</subject><subject>Internal medicine</subject><subject>Leukocidins - genetics</subject><subject>Levofloxacin</subject><subject>Male</subject><subject>Methicillin</subject><subject>Methicillin Resistance</subject><subject>Methicillin-Resistant Staphylococcus aureus - genetics</subject><subject>Methicillin-Resistant Staphylococcus aureus - isolation & purification</subject><subject>multiple cavity formation</subject><subject>necrotizing pneumonia</subject><subject>Panton-Valentine leukocidine (PVL) gene</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Pneumonia, Necrotizing - diagnostic imaging</subject><subject>Pneumonia, Necrotizing - drug therapy</subject><subject>Pneumonia, Necrotizing - microbiology</subject><subject>Pneumonia, Staphylococcal - diagnostic imaging</subject><subject>Pneumonia, Staphylococcal - drug therapy</subject><subject>Pneumonia, Staphylococcal - microbiology</subject><subject>Radiography</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Sulbactam</subject><subject>Tomography, X-Ray Computed</subject><issn>0918-2918</issn><issn>1349-7235</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkttuEzEQhlcIREPhFZAlbrjZ4tNu1jdIKGoLUloiTreW1ztJHHnt1IdI4e14MxwlRFBuZiTPNzP_eKaqEMFXlLTinXEJglN2hMFo4-CK8IbXpHtSTQjjop5S1jytJliQrqbFXFQvYtxgzLqpoM-rC4YZYxw3k-rXF7U1g92jRfCrADGaHaC7bJPZWkAztTNpj258GFUy3iHj0D3o4JP5adwKLRzk0TujCpkjDKjfo5kfx-xKWq30QzahvN5BWhed1hpXlx4mJuUS-prUdr23Xnutc0QqByhu4aNJBxFLH1BaA1oU1rv6h7LgUpkVzSGXFDMULbfg4GX1bKlshFcnf1l9v7n-NvtYzz_ffpp9mNd6SnCqRQ8UM9pAq8kS9x1vFO6hV0RgRcW06cSUiUE3mnLSE9azTg-ihHHL-oHSJbus3h_rbnNf_l0XNUFZuQ1mVGEvvTLy34gza7nyO9lyzhrOSoG3pwLBP2SISY4marBWOfA5SkoobQRloi3om0foxufDwgtFeStoxykpVHekykJiDLA8iyFYHu5EPr4TebgTSbqS-vrvYc6Jfw6jAPdHYFOWtYIzoEIy2sL_lZtONgdz6nAG9VoFCY79BlRl4qo</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Takigawa, Yuki</creator><creator>Fujiwara, Keiichi</creator><creator>Saito, Takashi</creator><creator>Nakasuka, Takamasa</creator><creator>Ozeki, Taichi</creator><creator>Okawa, Sachi</creator><creator>Takada, Kenji</creator><creator>Iwamoto, Yoshitaka</creator><creator>Kayatani, Hiroe</creator><creator>Minami, Daisuke</creator><creator>Sato, Ken</creator><creator>Nagao, Miki</creator><creator>Shibayama, Takuo</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190301</creationdate><title>Rapidly Progressive Multiple Cavity Formation in Necrotizing Pneumonia Caused by Community-acquired Methicillin-resistant Staphylococcus aureus Positive for the Panton-Valentine Leucocidin Gene</title><author>Takigawa, Yuki ; Fujiwara, Keiichi ; Saito, Takashi ; Nakasuka, Takamasa ; Ozeki, Taichi ; Okawa, Sachi ; Takada, Kenji ; Iwamoto, Yoshitaka ; Kayatani, Hiroe ; Minami, Daisuke ; Sato, Ken ; Nagao, Miki ; Shibayama, Takuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c710t-9be20325e6c1f0b845a0beba190a297589739dc5c241b13b38cd9ba1063bd22f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Ampicillin</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Bacterial Toxins - genetics</topic><topic>Case Report</topic><topic>Community-Acquired Infections - diagnostic imaging</topic><topic>Community-Acquired Infections - drug therapy</topic><topic>Community-Acquired Infections - microbiology</topic><topic>community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)</topic><topic>Computed tomography</topic><topic>Drug resistance</topic><topic>Exotoxins - genetics</topic><topic>Holes</topic><topic>Humans</topic><topic>influenza</topic><topic>Internal medicine</topic><topic>Leukocidins - genetics</topic><topic>Levofloxacin</topic><topic>Male</topic><topic>Methicillin</topic><topic>Methicillin Resistance</topic><topic>Methicillin-Resistant Staphylococcus aureus - genetics</topic><topic>Methicillin-Resistant Staphylococcus aureus - isolation & purification</topic><topic>multiple cavity formation</topic><topic>necrotizing pneumonia</topic><topic>Panton-Valentine leukocidine (PVL) gene</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Pneumonia, Necrotizing - diagnostic imaging</topic><topic>Pneumonia, Necrotizing - drug therapy</topic><topic>Pneumonia, Necrotizing - microbiology</topic><topic>Pneumonia, Staphylococcal - diagnostic imaging</topic><topic>Pneumonia, Staphylococcal - drug therapy</topic><topic>Pneumonia, Staphylococcal - microbiology</topic><topic>Radiography</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus infections</topic><topic>Sulbactam</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takigawa, Yuki</creatorcontrib><creatorcontrib>Fujiwara, Keiichi</creatorcontrib><creatorcontrib>Saito, Takashi</creatorcontrib><creatorcontrib>Nakasuka, Takamasa</creatorcontrib><creatorcontrib>Ozeki, Taichi</creatorcontrib><creatorcontrib>Okawa, Sachi</creatorcontrib><creatorcontrib>Takada, Kenji</creatorcontrib><creatorcontrib>Iwamoto, Yoshitaka</creatorcontrib><creatorcontrib>Kayatani, Hiroe</creatorcontrib><creatorcontrib>Minami, Daisuke</creatorcontrib><creatorcontrib>Sato, Ken</creatorcontrib><creatorcontrib>Nagao, Miki</creatorcontrib><creatorcontrib>Shibayama, Takuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takigawa, Yuki</au><au>Fujiwara, Keiichi</au><au>Saito, Takashi</au><au>Nakasuka, Takamasa</au><au>Ozeki, Taichi</au><au>Okawa, Sachi</au><au>Takada, Kenji</au><au>Iwamoto, Yoshitaka</au><au>Kayatani, Hiroe</au><au>Minami, Daisuke</au><au>Sato, Ken</au><au>Nagao, Miki</au><au>Shibayama, Takuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapidly Progressive Multiple Cavity Formation in Necrotizing Pneumonia Caused by Community-acquired Methicillin-resistant Staphylococcus aureus Positive for the Panton-Valentine Leucocidin Gene</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>58</volume><issue>5</issue><spage>685</spage><epage>691</epage><pages>685-691</pages><issn>0918-2918</issn><issn>1349-7235</issn><eissn>1349-7235</eissn><abstract>A 66-year-old man was transferred to our hospital for pneumonia that was resistant to sulbactam/ampicillin and levofloxacin therapy. Chest computed tomography showed the rapidly progressive formation of multiple cavities. Methicillin-resistant Staphylococcus aureus (MRSA) was isolated, and the patient was diagnosed with necrotizing pneumonia caused by community-acquired MRSA (CA-MRSA). The MRSA strain had type IV staphylococcus cassette chromosome mec and genes encoding Panton-Valentine leucocidin (PVL). CA-MRSA necrotizing pneumonia with the PVL gene is rare; only three cases have been previously reported in Japan. We administered anti-MRSA antibiotics and the patient achieved complete clinical and radiological improvement.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>30333405</pmid><doi>10.2169/internalmedicine.1454-18</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal Medicine, 2019/03/01, Vol.58(5), pp.685-691 |
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| source | MEDLINE; PubMed Central Open Access; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; PubMed Central |
| subjects | Aged Ampicillin Anti-Bacterial Agents - therapeutic use Antibiotics Bacterial Toxins - genetics Case Report Community-Acquired Infections - diagnostic imaging Community-Acquired Infections - drug therapy Community-Acquired Infections - microbiology community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) Computed tomography Drug resistance Exotoxins - genetics Holes Humans influenza Internal medicine Leukocidins - genetics Levofloxacin Male Methicillin Methicillin Resistance Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - isolation & purification multiple cavity formation necrotizing pneumonia Panton-Valentine leukocidine (PVL) gene Patients Pneumonia Pneumonia, Necrotizing - diagnostic imaging Pneumonia, Necrotizing - drug therapy Pneumonia, Necrotizing - microbiology Pneumonia, Staphylococcal - diagnostic imaging Pneumonia, Staphylococcal - drug therapy Pneumonia, Staphylococcal - microbiology Radiography Staphylococcus aureus Staphylococcus infections Sulbactam Tomography, X-Ray Computed |
| title | Rapidly Progressive Multiple Cavity Formation in Necrotizing Pneumonia Caused by Community-acquired Methicillin-resistant Staphylococcus aureus Positive for the Panton-Valentine Leucocidin Gene |
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