Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis

BACKGROUND:Hypertrophic response to pathological stimuli is a complex biological process that involves transcriptional and epigenetic regulation of the cardiac transcriptome. Although previous studies have implicated transcriptional factors and signaling molecules in pathological hypertrophy, the ro...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2019-04, Vol.139 (14), p.1725-1740
Hauptverfasser:	Ma, Hong, Yu, Shuo, Liu, Xiaojing, Zhang, Yingao, Fakadej, Thomas, Liu, Ziqing, Yin, Chaoying, Shen, Weining, Locasale, Jason W, Taylor, Joan M, Qian, Li, Liu, Jiandong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Cells, Cultured Disease Models, Animal Energy Metabolism Glycolysis Hypertrophy, Left Ventricular - enzymology Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - pathology Hypertrophy, Left Ventricular - physiopathology Mice, Knockout Mitochondria, Heart - enzymology Mitochondria, Heart - pathology Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Phosphoenolpyruvate Carboxykinase (ATP) - genetics Phosphoenolpyruvate Carboxykinase (ATP) - metabolism Protein Binding Rats, Sprague-Dawley RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Ventricular Function, Left Ventricular Remodeling
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