Characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis
To compare the clinical characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis. This is a retrospective cohort study that included all patients with a diagnosis of sepsis detected between January 2010 and December 2015 at a private hospital in southern Brazil....
Gespeichert in:
| Veröffentlicht in: | Revista Brasileira de terapia intensiva 2019-01, Vol.31 (1), p.71-78 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng ; por |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 78 |
|---|---|
| container_issue | 1 |
| container_start_page | 71 |
| container_title | Revista Brasileira de terapia intensiva |
| container_volume | 31 |
| creator | Westphal, Glauco Adrieno Pereira, Aline Braz Fachin, Silvia Maria Barreto, Ana Carolina Caldara Bornschein, Ana Carolina Gern Junqueira Caldeira Filho, Milton Koenig, Álvaro |
| description | To compare the clinical characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis.
This is a retrospective cohort study that included all patients with a diagnosis of sepsis detected between January 2010 and December 2015 at a private hospital in southern Brazil. Outcomes (mortality, intensive care unit and hospital lengths of stay) were measured by analyzing electronic records.
There were 543 hospitalized patients with a diagnosis of sepsis, with a frequency of 90.5 (85 to 105) cases/year. Of these, 319 (58%) cases were classified as hospital-acquired sepsis. This group exhibited more severe disease and had a larger number of organ dysfunctions, with higher hospital [8 (8 - 10) versus 23 (20 - 27) days; p < 0.001] and intensive care unit [5 (4 - 7) versus 8.5 (7 - 10); p < 0.001] lengths of stay and higher in-hospital mortality (30.7% versus 15.6%; p < 0.001) than those with community-acquired sepsis. After adjusting for age, APACHE II scores, and hemodynamic and respiratory dysfunction, hospital-acquired sepsis remained associated with increased mortality (OR 1.96; 95%CI 1.15 - 3.32, p = 0.013).
The present results contribute to the definition of the epidemiological profile of sepsis in the sample studied, in which hospital-acquired sepsis was more severe and was associated with higher mortality. |
| doi_str_mv | 10.5935/0103-507X.20190013 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6443308</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>30970093</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3173-96c946d33643148dbd646f69003fb8b746624469965c3f9302f43e97499314903</originalsourceid><addsrcrecordid>eNpVkMtOwzAQRS0EouXxAyxQfiBlnHGceIOEKl5SJTYgsUGW4zjEqHlgO6D-PSmlBVYj3Zl7Z-YQckZhlgpML4ACxilkz7MEqACguEemVORJzBDTfTLdDUzIkfdvABwo54dkgiAyAIFT8jKvlVM6GGd9sNpHqi2jbgi6a4yPuirqVbCmDT76tKGORrkZWhtWsdLvg3Wm_DbUne9tUMtf1ZveW39CDiq19Ob0px6Tp5vrx_ldvHi4vZ9fLWKNNMNYcC0YLxE5Q8rysig54xUfX8KqyIuMcZ4wxoXgqcZKICQVQyMyJsQ4LwCPyeUmtx-KxpR6PNippeydbZRbyU5Z-b_T2lq-dh-SsxEV5GNAsgnQrvPemWrnpSDXsOWapVyzlFvYo-n879adZUsXvwD6-Xuu</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Westphal, Glauco Adrieno ; Pereira, Aline Braz ; Fachin, Silvia Maria ; Barreto, Ana Carolina Caldara ; Bornschein, Ana Carolina Gern Junqueira ; Caldeira Filho, Milton ; Koenig, Álvaro</creator><creatorcontrib>Westphal, Glauco Adrieno ; Pereira, Aline Braz ; Fachin, Silvia Maria ; Barreto, Ana Carolina Caldara ; Bornschein, Ana Carolina Gern Junqueira ; Caldeira Filho, Milton ; Koenig, Álvaro</creatorcontrib><description>To compare the clinical characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis.
This is a retrospective cohort study that included all patients with a diagnosis of sepsis detected between January 2010 and December 2015 at a private hospital in southern Brazil. Outcomes (mortality, intensive care unit and hospital lengths of stay) were measured by analyzing electronic records.
There were 543 hospitalized patients with a diagnosis of sepsis, with a frequency of 90.5 (85 to 105) cases/year. Of these, 319 (58%) cases were classified as hospital-acquired sepsis. This group exhibited more severe disease and had a larger number of organ dysfunctions, with higher hospital [8 (8 - 10) versus 23 (20 - 27) days; p < 0.001] and intensive care unit [5 (4 - 7) versus 8.5 (7 - 10); p < 0.001] lengths of stay and higher in-hospital mortality (30.7% versus 15.6%; p < 0.001) than those with community-acquired sepsis. After adjusting for age, APACHE II scores, and hemodynamic and respiratory dysfunction, hospital-acquired sepsis remained associated with increased mortality (OR 1.96; 95%CI 1.15 - 3.32, p = 0.013).
The present results contribute to the definition of the epidemiological profile of sepsis in the sample studied, in which hospital-acquired sepsis was more severe and was associated with higher mortality.</description><identifier>ISSN: 0103-507X</identifier><identifier>EISSN: 1982-4335</identifier><identifier>DOI: 10.5935/0103-507X.20190013</identifier><identifier>PMID: 30970093</identifier><language>eng ; por</language><publisher>Brazil: Associação de Medicina Intensiva Brasileira - AMIB</publisher><subject>Aged ; APACHE ; Brazil ; Cohort Studies ; Cross Infection - mortality ; Cross Infection - physiopathology ; Female ; Hospital Mortality ; Hospitals, Private ; Humans ; Intensive Care Units - statistics & numerical data ; Length of Stay ; Male ; Middle Aged ; Original ; Retrospective Studies ; Sepsis - mortality ; Sepsis - physiopathology</subject><ispartof>Revista Brasileira de terapia intensiva, 2019-01, Vol.31 (1), p.71-78</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3173-96c946d33643148dbd646f69003fb8b746624469965c3f9302f43e97499314903</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443308/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443308/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30970093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westphal, Glauco Adrieno</creatorcontrib><creatorcontrib>Pereira, Aline Braz</creatorcontrib><creatorcontrib>Fachin, Silvia Maria</creatorcontrib><creatorcontrib>Barreto, Ana Carolina Caldara</creatorcontrib><creatorcontrib>Bornschein, Ana Carolina Gern Junqueira</creatorcontrib><creatorcontrib>Caldeira Filho, Milton</creatorcontrib><creatorcontrib>Koenig, Álvaro</creatorcontrib><title>Characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis</title><title>Revista Brasileira de terapia intensiva</title><addtitle>Rev Bras Ter Intensiva</addtitle><description>To compare the clinical characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis.
This is a retrospective cohort study that included all patients with a diagnosis of sepsis detected between January 2010 and December 2015 at a private hospital in southern Brazil. Outcomes (mortality, intensive care unit and hospital lengths of stay) were measured by analyzing electronic records.
There were 543 hospitalized patients with a diagnosis of sepsis, with a frequency of 90.5 (85 to 105) cases/year. Of these, 319 (58%) cases were classified as hospital-acquired sepsis. This group exhibited more severe disease and had a larger number of organ dysfunctions, with higher hospital [8 (8 - 10) versus 23 (20 - 27) days; p < 0.001] and intensive care unit [5 (4 - 7) versus 8.5 (7 - 10); p < 0.001] lengths of stay and higher in-hospital mortality (30.7% versus 15.6%; p < 0.001) than those with community-acquired sepsis. After adjusting for age, APACHE II scores, and hemodynamic and respiratory dysfunction, hospital-acquired sepsis remained associated with increased mortality (OR 1.96; 95%CI 1.15 - 3.32, p = 0.013).
The present results contribute to the definition of the epidemiological profile of sepsis in the sample studied, in which hospital-acquired sepsis was more severe and was associated with higher mortality.</description><subject>Aged</subject><subject>APACHE</subject><subject>Brazil</subject><subject>Cohort Studies</subject><subject>Cross Infection - mortality</subject><subject>Cross Infection - physiopathology</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Hospitals, Private</subject><subject>Humans</subject><subject>Intensive Care Units - statistics & numerical data</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Retrospective Studies</subject><subject>Sepsis - mortality</subject><subject>Sepsis - physiopathology</subject><issn>0103-507X</issn><issn>1982-4335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtOwzAQRS0EouXxAyxQfiBlnHGceIOEKl5SJTYgsUGW4zjEqHlgO6D-PSmlBVYj3Zl7Z-YQckZhlgpML4ACxilkz7MEqACguEemVORJzBDTfTLdDUzIkfdvABwo54dkgiAyAIFT8jKvlVM6GGd9sNpHqi2jbgi6a4yPuirqVbCmDT76tKGORrkZWhtWsdLvg3Wm_DbUne9tUMtf1ZveW39CDiq19Ob0px6Tp5vrx_ldvHi4vZ9fLWKNNMNYcC0YLxE5Q8rysig54xUfX8KqyIuMcZ4wxoXgqcZKICQVQyMyJsQ4LwCPyeUmtx-KxpR6PNippeydbZRbyU5Z-b_T2lq-dh-SsxEV5GNAsgnQrvPemWrnpSDXsOWapVyzlFvYo-n879adZUsXvwD6-Xuu</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Westphal, Glauco Adrieno</creator><creator>Pereira, Aline Braz</creator><creator>Fachin, Silvia Maria</creator><creator>Barreto, Ana Carolina Caldara</creator><creator>Bornschein, Ana Carolina Gern Junqueira</creator><creator>Caldeira Filho, Milton</creator><creator>Koenig, Álvaro</creator><general>Associação de Medicina Intensiva Brasileira - AMIB</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201901</creationdate><title>Characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis</title><author>Westphal, Glauco Adrieno ; Pereira, Aline Braz ; Fachin, Silvia Maria ; Barreto, Ana Carolina Caldara ; Bornschein, Ana Carolina Gern Junqueira ; Caldeira Filho, Milton ; Koenig, Álvaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3173-96c946d33643148dbd646f69003fb8b746624469965c3f9302f43e97499314903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2019</creationdate><topic>Aged</topic><topic>APACHE</topic><topic>Brazil</topic><topic>Cohort Studies</topic><topic>Cross Infection - mortality</topic><topic>Cross Infection - physiopathology</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Hospitals, Private</topic><topic>Humans</topic><topic>Intensive Care Units - statistics & numerical data</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Retrospective Studies</topic><topic>Sepsis - mortality</topic><topic>Sepsis - physiopathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Westphal, Glauco Adrieno</creatorcontrib><creatorcontrib>Pereira, Aline Braz</creatorcontrib><creatorcontrib>Fachin, Silvia Maria</creatorcontrib><creatorcontrib>Barreto, Ana Carolina Caldara</creatorcontrib><creatorcontrib>Bornschein, Ana Carolina Gern Junqueira</creatorcontrib><creatorcontrib>Caldeira Filho, Milton</creatorcontrib><creatorcontrib>Koenig, Álvaro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Revista Brasileira de terapia intensiva</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westphal, Glauco Adrieno</au><au>Pereira, Aline Braz</au><au>Fachin, Silvia Maria</au><au>Barreto, Ana Carolina Caldara</au><au>Bornschein, Ana Carolina Gern Junqueira</au><au>Caldeira Filho, Milton</au><au>Koenig, Álvaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis</atitle><jtitle>Revista Brasileira de terapia intensiva</jtitle><addtitle>Rev Bras Ter Intensiva</addtitle><date>2019-01</date><risdate>2019</risdate><volume>31</volume><issue>1</issue><spage>71</spage><epage>78</epage><pages>71-78</pages><issn>0103-507X</issn><eissn>1982-4335</eissn><abstract>To compare the clinical characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis.
This is a retrospective cohort study that included all patients with a diagnosis of sepsis detected between January 2010 and December 2015 at a private hospital in southern Brazil. Outcomes (mortality, intensive care unit and hospital lengths of stay) were measured by analyzing electronic records.
There were 543 hospitalized patients with a diagnosis of sepsis, with a frequency of 90.5 (85 to 105) cases/year. Of these, 319 (58%) cases were classified as hospital-acquired sepsis. This group exhibited more severe disease and had a larger number of organ dysfunctions, with higher hospital [8 (8 - 10) versus 23 (20 - 27) days; p < 0.001] and intensive care unit [5 (4 - 7) versus 8.5 (7 - 10); p < 0.001] lengths of stay and higher in-hospital mortality (30.7% versus 15.6%; p < 0.001) than those with community-acquired sepsis. After adjusting for age, APACHE II scores, and hemodynamic and respiratory dysfunction, hospital-acquired sepsis remained associated with increased mortality (OR 1.96; 95%CI 1.15 - 3.32, p = 0.013).
The present results contribute to the definition of the epidemiological profile of sepsis in the sample studied, in which hospital-acquired sepsis was more severe and was associated with higher mortality.</abstract><cop>Brazil</cop><pub>Associação de Medicina Intensiva Brasileira - AMIB</pub><pmid>30970093</pmid><doi>10.5935/0103-507X.20190013</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0103-507X |
| ispartof | Revista Brasileira de terapia intensiva, 2019-01, Vol.31 (1), p.71-78 |
| issn | 0103-507X 1982-4335 |
| language | eng ; por |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6443308 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Aged APACHE Brazil Cohort Studies Cross Infection - mortality Cross Infection - physiopathology Female Hospital Mortality Hospitals, Private Humans Intensive Care Units - statistics & numerical data Length of Stay Male Middle Aged Original Retrospective Studies Sepsis - mortality Sepsis - physiopathology |
| title | Characteristics and outcomes of patients with community-acquired and hospital-acquired sepsis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T11%3A19%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characteristics%20and%20outcomes%20of%20patients%20with%20community-acquired%20and%20hospital-acquired%20sepsis&rft.jtitle=Revista%20Brasileira%20de%20terapia%20intensiva&rft.au=Westphal,%20Glauco%20Adrieno&rft.date=2019-01&rft.volume=31&rft.issue=1&rft.spage=71&rft.epage=78&rft.pages=71-78&rft.issn=0103-507X&rft.eissn=1982-4335&rft_id=info:doi/10.5935/0103-507X.20190013&rft_dat=%3Cpubmed_cross%3E30970093%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/30970093&rfr_iscdi=true |