Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive

There is great interest in being able to spread beneficial traits throughout wild populations in ways that are self-sustaining. Here, we describe a chromosomal selfish genetic element, CleaveR [Cleave and Rescue (ClvR)], able to achieve this goal. ClvR comprises two linked chromosomal components. On...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-03, Vol.116 (13), p.6250-6259
Hauptverfasser:	Oberhofer, Georg, Ivy, Tobin, Hay, Bruce A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Behavior, Animal Biological Sciences Chromosome 3 chromosomes CRISPR-Associated Protein 9 - genetics Deactivation death Drosophila melanogaster Drosophila melanogaster - genetics Drosophila virilis Female Fixation Fruit flies Gene conversion Gene Drive Technology - methods Gene Knockout Techniques Genes, Essential - genetics Genes, X-Linked Genetic diversity genetic variation Genetics, Population Genotype Germ Cells Inactivation Insects Lethality Male Models, Genetic Phenotype PNAS Plus Population Dynamics Populations Predictions Progeny Repetitive Sequences, Nucleic Acid RNA, Guide, CRISPR-Cas Systems Transgenes X Chromosome
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