8-Oxo-guanine DNA damage induces transcription errors by escaping two distinct fidelity control checkpoints of RNA polymerase II

RNA polymerase II (Pol II) has an intrinsic fidelity control mechanism to maintain faithful genetic information transfer during transcription. 8-Oxo-guanine (8OG), a commonly occurring damaged guanine base, promotes misincorporation of adenine into the RNA strand. Recent structural work has shown th...

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Veröffentlicht in:	The Journal of biological chemistry 2019-03, Vol.294 (13), p.4924-4933
Hauptverfasser:	Konovalov, Kirill A., Pardo-Avila, Fátima, Tse, Carmen Ka Man, Oh, Juntaek, Wang, Dong, Huang, Xuhui
Format:	Artikel
Sprache:	eng
Schlagworte:	8-oxo-guanine (8OG) Adenosine Triphosphate - chemistry Catalytic Domain DNA Damage Guanine - analogs & derivatives Guanine - chemistry Models, Chemical Molecular Biophysics molecular dynamics mutagenesis mechanism nucleotide misincorporation RNA polymerase II RNA Polymerase II - chemistry Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae Proteins - chemistry transcription transcriptional bypass transcriptional fidelity
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