Crimean-Congo hemorrhagic fever virus nucleocapsid protein harbors distinct RNA-binding sites in the stalk and head domains

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne Nairovirus that causes severe hemorrhagic fever with a mortality rate of up to 30% in certain outbreaks worldwide. The virus has wide endemic distribution. There is no effective antiviral therapeutic or FDA approved vaccine for this zoono...

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Veröffentlicht in:	The Journal of biological chemistry 2019-03, Vol.294 (13), p.5023-5037
Hauptverfasser:	Jeeva, Subbiah, Mir, Sheema, Velasquez, Adrain, Ragan, Jacquelyn, Leka, Aljona, Wu, Sharon, Sevarany, Ariga Tahmasian, Royster, Austin D., Almeida, Nicholas A., Chan, Fion, O’Brien, Lea, Mir, Mohammad Ayoub
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites C-C chemokine receptor type 5 (CCR5) CCHF Hemorrhagic Fever Virus, Crimean-Congo - chemistry Hemorrhagic Fever Virus, Crimean-Congo - physiology Hemorrhagic Fever, Crimean - metabolism Hemorrhagic Fever, Crimean - virology Humans Models, Molecular Molecular Bases of Disease Nairovirus - chemistry Nairovirus - physiology nucleocapsid Nucleocapsid Proteins - chemistry Nucleocapsid Proteins - metabolism Protein Domains RNA - metabolism RNA-protein interaction viral polymerase viral protein viral replication virology Virus Replication
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