Pilot study of DNA methylation-derived neutrophil-to-lymphocyte ratio and survival in pediatric medulloblastoma

•Neutrophil-to-lymphocyte ratio (NLR) can be estimated from DNA methylation data.•Elevated methylation-derived NLR linked to mortality in pediatric medulloblastoma.•This association was independent of demographic and clinical factors. Methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) has be...

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Veröffentlicht in:	Cancer epidemiology 2019-04, Vol.59, p.71-74
Hauptverfasser:	Arroyo, Vidal M., Lupo, Philip J., Scheurer, Michael E., Rednam, Surya P., Murray, Jeffrey, Okcu, M. Fatih, Chintagumpala, Murali M., Brown, Austin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Biomarkers Blood Brain cancer Brain research Cancer Cancer therapies Cerebellar Neoplasms - blood Cerebellar Neoplasms - diagnosis Cerebellar Neoplasms - drug therapy Cerebellar Neoplasms - genetics Child Child, Preschool Clinical outcomes Confidence intervals Deoxyribonucleic acid DNA DNA Methylation Epidemiology Ethnicity Female Granulocytes Humans Inflammation Leukocyte Count Lymphocytes Male Measurement methods Medical prognosis Medulloblastoma Medulloblastoma - blood Medulloblastoma - diagnosis Medulloblastoma - drug therapy Medulloblastoma - genetics Neutrophils Patients Pediatrics Peripheral blood Pilot Projects Prognosis Proportional Hazards Models Quality control Retrospective Studies Statistical models Subgroups Survival Tumors
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