Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis

OBJECTIVE—Vascular calcification is a common and severe complication in patients with atherosclerosis which is exacerbated by type 2 diabetes mellitus. Our laboratory recently reported that the collagen receptor discoidin domain receptor 1 (DDR1) mediates vascular calcification in atherosclerosis; h...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2018-08, Vol.38 (8), p.1878-1889
Hauptverfasser:	Lino, Marsel, Wan, Mark H, Rocca, Antonio S, Ngai, David, Shobeiri, Navid, Hou, Guangpei, Ge, Chunxi, Franceschi, Renny T, Bendeck, Michelle P
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Atherosclerosis - enzymology Atherosclerosis - genetics Atherosclerosis - pathology Cells, Cultured Core Binding Factor Alpha 1 Subunit - metabolism Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Diabetic Angiopathies - enzymology Diabetic Angiopathies - genetics Diabetic Angiopathies - pathology Diet, High-Fat Discoidin Domain Receptor 1 - deficiency Discoidin Domain Receptor 1 - genetics Discoidin Domain Receptor 1 - metabolism Disease Models, Animal Male Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology Phosphatidylinositol 3-Kinase - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptors, LDL - deficiency Receptors, LDL - genetics Signal Transduction Vascular Calcification - enzymology Vascular Calcification - genetics Vascular Calcification - pathology
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