Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease

Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease

To evaluate the clinical effectiveness of a topical sialogogue spray (malic acid, 1%) in the treatment of xerostomia in patients with chronic Graft versus Host Disease (cGVHD). This study was designed as a randomized double-blind clinical study. Twenty-eight patients with cGVHD suffering from xerost...

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Veröffentlicht in:Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2019-03, Vol.24 (2), p.e190-e194
Hauptverfasser: Bardellini, E, Amadori, F, Conti, G, Veneri, F, Majorana, A
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container_title Medicina oral, patología oral y cirugía bucal
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creator Bardellini, E
Amadori, F
Conti, G
Veneri, F
Majorana, A
description To evaluate the clinical effectiveness of a topical sialogogue spray (malic acid, 1%) in the treatment of xerostomia in patients with chronic Graft versus Host Disease (cGVHD). This study was designed as a randomized double-blind clinical study. Twenty-eight patients with cGVHD suffering from xerostomia were divided into 2 groups: the first group (14 patients) received a topical sialagogue spray containing malic acid 1% (SalivAktive®) whereas the second group (14 patients) received a placebo. Both groups received treatment for 2 weeks. Dry Mouth Questionnaire (DMQ) scores and unstimulated salivary flows rate were collected before and after treatment. DMQ scores increased significantly from 1.3 ± 0.4 to 3.5 ± 0.4 points (p0.05). The unstimulated salivary flow rate in patients treated with malic acid increased significantly from 0.15 ± 0.06 mL/min to 0.24± 0.08 mL/min, while that of the patients treated with placebo went from 0.16 ± 0.07 mL/min to 0.17 ± 0.09 mL/min (p>0.05). Malic acid 1% spray can be considered effective in the treatment of GVHD induced xerostomia.
doi_str_mv 10.4317/medoral.22699
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title Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease
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