Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats
Rationale Drug addiction can be described as aberrant allocation of effort toward acquiring drug, despite associated costs. It is unclear if this behavioral pattern results from an overvaluation of reward or to an altered sensitivity to costs. Objective Present experiments assessed reward sensitivit...
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| Veröffentlicht in: | Psychopharmacology 2017-09, Vol.234 (18), p.2697-2705 |
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| creator | Thompson, Andrew B. Gerson, Julian Stolyarova, Alexandra Bugarin, Amador Hart, Evan E. Jentsch, J. David Izquierdo, Alicia |
| description | Rationale
Drug addiction can be described as aberrant allocation of effort toward acquiring drug, despite associated costs. It is unclear if this behavioral pattern results from an overvaluation of reward or to an altered sensitivity to costs.
Objective
Present experiments assessed reward sensitivity and effortful choice in rats following 1 week of withdrawal from methamphetamine (mAMPH).
Methods
Rats were treated with either saline or an escalating dose mAMPH regimen, then tested after a week without the drug. In experiment 1, rats were given a free choice between water and various concentrations of sucrose solution to assess general reward sensitivity. In experiment 2, rats were presented with a choice between lever-pressing for sucrose pellets on a progressive ratio schedule or consuming freely-available chow.
Results
In experiment 1, we found no differences in sucrose preference between mAMPH- and saline-pretreated rats. In experiment 2, when selecting between two options, mAMPH-pretreated rats engaged in less lever-pressing for sucrose pellets (
p
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| doi_str_mv | 10.1007/s00213-017-4656-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6441328</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A501633121</galeid><sourcerecordid>A501633121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-5e38ca4e02d11c8d5c865298bb130899e615d83069b3c73acda26411598717963</originalsourceid><addsrcrecordid>eNp1Uk1v1DAQtRCILgs_gAuKxIVLir_jXJCqihakShyAs-V1JruuEjs43l21R345s9pSWgT2wdLMe8-aeY-Q14yeMkqb9zOlnImasqaWWun69glZMCl4zWnDn5IFpULUgilzQl7M8zXFI418Tk64UUa2vF2Qn18LwFRB36dcqi7MPm1jCXFdpb5y1ZShh5yhqzLsXe6qtIOM9T4DDDe127kwuNUAVZpKSLEKESlpSHGNlBHKxo3TBoobQ4RqH8qmy27vhgNudEjLrswvybPeDTO8unuX5PvFx2_nn-qrL5efz8-uaq9EU2oFwngngfKOMW865Y1WvDWrFRPUtC1opjojqG5XwjfC-c5xLRlTrWlY02qxJB-OutN2NULnIZbsBjvlMLp8Y5ML9nEnho1dp53VUjLBDQq8uxPI6ccW5mJH3BcMg4uQtrNlLdVSay0pQt_-Bb1O2xxxPEShI4rzVvxBrXEXNsQ-4b_-IGrPFGVaCIb-LsnpP1B4OxiDTxH6gPVHBHYk-JzmGR28n5FRewiOPQbHYnDsITj2FjlvHi7nnvE7KQjgR8CMLbQ3P5jov6q_ABLDzvo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1931552293</pqid></control><display><type>article</type><title>Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Thompson, Andrew B. ; Gerson, Julian ; Stolyarova, Alexandra ; Bugarin, Amador ; Hart, Evan E. ; Jentsch, J. David ; Izquierdo, Alicia</creator><creatorcontrib>Thompson, Andrew B. ; Gerson, Julian ; Stolyarova, Alexandra ; Bugarin, Amador ; Hart, Evan E. ; Jentsch, J. David ; Izquierdo, Alicia</creatorcontrib><description>Rationale
Drug addiction can be described as aberrant allocation of effort toward acquiring drug, despite associated costs. It is unclear if this behavioral pattern results from an overvaluation of reward or to an altered sensitivity to costs.
Objective
Present experiments assessed reward sensitivity and effortful choice in rats following 1 week of withdrawal from methamphetamine (mAMPH).
Methods
Rats were treated with either saline or an escalating dose mAMPH regimen, then tested after a week without the drug. In experiment 1, rats were given a free choice between water and various concentrations of sucrose solution to assess general reward sensitivity. In experiment 2, rats were presented with a choice between lever-pressing for sucrose pellets on a progressive ratio schedule or consuming freely-available chow.
Results
In experiment 1, we found no differences in sucrose preference between mAMPH- and saline-pretreated rats. In experiment 2, when selecting between two options, mAMPH-pretreated rats engaged in less lever-pressing for sucrose pellets (
p
< 0.01) and switched from this preferred reward to the chow sooner than saline-pretreated rats (
p
< 0.05). This effect was not consistent with general reward devaluation or loss of motivation.
Conclusions
These findings demonstrate that mAMPH exposure and withdrawal lead to steeper discounting of reward value by effort, an effect that is consistent with the effect of mAMPH on discounting by delay, and which may reflect an underlying shared mechanism.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-017-4656-z</identifier><identifier>PMID: 28584929</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animal behavior ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Central Nervous System Stimulants - pharmacology ; Choice Behavior - drug effects ; Choice Behavior - physiology ; Complications and side effects ; Delay Discounting - drug effects ; Delay Discounting - physiology ; Drug abuse ; Drug addiction ; Drug interactions ; Drug withdrawal ; Experiments ; Male ; Males ; Methamphetamine ; Methamphetamine - pharmacology ; Motivation ; Motivation - drug effects ; Motivation - physiology ; Neurosciences ; Observations ; Original Investigation ; Pellets ; Pharmacology/Toxicology ; Psychiatry ; Psychopharmacology ; Rats ; Rats, Long-Evans ; Reinforcement ; Reward ; Rodents ; Sensitivity ; Substance Withdrawal Syndrome - psychology ; Sucrose ; Sugar ; Time Factors ; Withdrawal</subject><ispartof>Psychopharmacology, 2017-09, Vol.234 (18), p.2697-2705</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Psychopharmacology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-5e38ca4e02d11c8d5c865298bb130899e615d83069b3c73acda26411598717963</citedby><cites>FETCH-LOGICAL-c537t-5e38ca4e02d11c8d5c865298bb130899e615d83069b3c73acda26411598717963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-017-4656-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-017-4656-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28584929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thompson, Andrew B.</creatorcontrib><creatorcontrib>Gerson, Julian</creatorcontrib><creatorcontrib>Stolyarova, Alexandra</creatorcontrib><creatorcontrib>Bugarin, Amador</creatorcontrib><creatorcontrib>Hart, Evan E.</creatorcontrib><creatorcontrib>Jentsch, J. David</creatorcontrib><creatorcontrib>Izquierdo, Alicia</creatorcontrib><title>Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
Drug addiction can be described as aberrant allocation of effort toward acquiring drug, despite associated costs. It is unclear if this behavioral pattern results from an overvaluation of reward or to an altered sensitivity to costs.
Objective
Present experiments assessed reward sensitivity and effortful choice in rats following 1 week of withdrawal from methamphetamine (mAMPH).
Methods
Rats were treated with either saline or an escalating dose mAMPH regimen, then tested after a week without the drug. In experiment 1, rats were given a free choice between water and various concentrations of sucrose solution to assess general reward sensitivity. In experiment 2, rats were presented with a choice between lever-pressing for sucrose pellets on a progressive ratio schedule or consuming freely-available chow.
Results
In experiment 1, we found no differences in sucrose preference between mAMPH- and saline-pretreated rats. In experiment 2, when selecting between two options, mAMPH-pretreated rats engaged in less lever-pressing for sucrose pellets (
p
< 0.01) and switched from this preferred reward to the chow sooner than saline-pretreated rats (
p
< 0.05). This effect was not consistent with general reward devaluation or loss of motivation.
Conclusions
These findings demonstrate that mAMPH exposure and withdrawal lead to steeper discounting of reward value by effort, an effect that is consistent with the effect of mAMPH on discounting by delay, and which may reflect an underlying shared mechanism.</description><subject>Animal behavior</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Choice Behavior - drug effects</subject><subject>Choice Behavior - physiology</subject><subject>Complications and side effects</subject><subject>Delay Discounting - drug effects</subject><subject>Delay Discounting - physiology</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Drug interactions</subject><subject>Drug withdrawal</subject><subject>Experiments</subject><subject>Male</subject><subject>Males</subject><subject>Methamphetamine</subject><subject>Methamphetamine - pharmacology</subject><subject>Motivation</subject><subject>Motivation - drug effects</subject><subject>Motivation - physiology</subject><subject>Neurosciences</subject><subject>Observations</subject><subject>Original Investigation</subject><subject>Pellets</subject><subject>Pharmacology/Toxicology</subject><subject>Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Reinforcement</subject><subject>Reward</subject><subject>Rodents</subject><subject>Sensitivity</subject><subject>Substance Withdrawal Syndrome - psychology</subject><subject>Sucrose</subject><subject>Sugar</subject><subject>Time Factors</subject><subject>Withdrawal</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1Uk1v1DAQtRCILgs_gAuKxIVLir_jXJCqihakShyAs-V1JruuEjs43l21R345s9pSWgT2wdLMe8-aeY-Q14yeMkqb9zOlnImasqaWWun69glZMCl4zWnDn5IFpULUgilzQl7M8zXFI418Tk64UUa2vF2Qn18LwFRB36dcqi7MPm1jCXFdpb5y1ZShh5yhqzLsXe6qtIOM9T4DDDe127kwuNUAVZpKSLEKESlpSHGNlBHKxo3TBoobQ4RqH8qmy27vhgNudEjLrswvybPeDTO8unuX5PvFx2_nn-qrL5efz8-uaq9EU2oFwngngfKOMW865Y1WvDWrFRPUtC1opjojqG5XwjfC-c5xLRlTrWlY02qxJB-OutN2NULnIZbsBjvlMLp8Y5ML9nEnho1dp53VUjLBDQq8uxPI6ccW5mJH3BcMg4uQtrNlLdVSay0pQt_-Bb1O2xxxPEShI4rzVvxBrXEXNsQ-4b_-IGrPFGVaCIb-LsnpP1B4OxiDTxH6gPVHBHYk-JzmGR28n5FRewiOPQbHYnDsITj2FjlvHi7nnvE7KQjgR8CMLbQ3P5jov6q_ABLDzvo</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Thompson, Andrew B.</creator><creator>Gerson, Julian</creator><creator>Stolyarova, Alexandra</creator><creator>Bugarin, Amador</creator><creator>Hart, Evan E.</creator><creator>Jentsch, J. David</creator><creator>Izquierdo, Alicia</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170901</creationdate><title>Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats</title><author>Thompson, Andrew B. ; Gerson, Julian ; Stolyarova, Alexandra ; Bugarin, Amador ; Hart, Evan E. ; Jentsch, J. David ; Izquierdo, Alicia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-5e38ca4e02d11c8d5c865298bb130899e615d83069b3c73acda26411598717963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animal behavior</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Choice Behavior - drug effects</topic><topic>Choice Behavior - physiology</topic><topic>Complications and side effects</topic><topic>Delay Discounting - drug effects</topic><topic>Delay Discounting - physiology</topic><topic>Drug abuse</topic><topic>Drug addiction</topic><topic>Drug interactions</topic><topic>Drug withdrawal</topic><topic>Experiments</topic><topic>Male</topic><topic>Males</topic><topic>Methamphetamine</topic><topic>Methamphetamine - pharmacology</topic><topic>Motivation</topic><topic>Motivation - drug effects</topic><topic>Motivation - physiology</topic><topic>Neurosciences</topic><topic>Observations</topic><topic>Original Investigation</topic><topic>Pellets</topic><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Reinforcement</topic><topic>Reward</topic><topic>Rodents</topic><topic>Sensitivity</topic><topic>Substance Withdrawal Syndrome - psychology</topic><topic>Sucrose</topic><topic>Sugar</topic><topic>Time Factors</topic><topic>Withdrawal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson, Andrew B.</creatorcontrib><creatorcontrib>Gerson, Julian</creatorcontrib><creatorcontrib>Stolyarova, Alexandra</creatorcontrib><creatorcontrib>Bugarin, Amador</creatorcontrib><creatorcontrib>Hart, Evan E.</creatorcontrib><creatorcontrib>Jentsch, J. David</creatorcontrib><creatorcontrib>Izquierdo, Alicia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson, Andrew B.</au><au>Gerson, Julian</au><au>Stolyarova, Alexandra</au><au>Bugarin, Amador</au><au>Hart, Evan E.</au><au>Jentsch, J. David</au><au>Izquierdo, Alicia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>234</volume><issue>18</issue><spage>2697</spage><epage>2705</epage><pages>2697-2705</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale
Drug addiction can be described as aberrant allocation of effort toward acquiring drug, despite associated costs. It is unclear if this behavioral pattern results from an overvaluation of reward or to an altered sensitivity to costs.
Objective
Present experiments assessed reward sensitivity and effortful choice in rats following 1 week of withdrawal from methamphetamine (mAMPH).
Methods
Rats were treated with either saline or an escalating dose mAMPH regimen, then tested after a week without the drug. In experiment 1, rats were given a free choice between water and various concentrations of sucrose solution to assess general reward sensitivity. In experiment 2, rats were presented with a choice between lever-pressing for sucrose pellets on a progressive ratio schedule or consuming freely-available chow.
Results
In experiment 1, we found no differences in sucrose preference between mAMPH- and saline-pretreated rats. In experiment 2, when selecting between two options, mAMPH-pretreated rats engaged in less lever-pressing for sucrose pellets (
p
< 0.01) and switched from this preferred reward to the chow sooner than saline-pretreated rats (
p
< 0.05). This effect was not consistent with general reward devaluation or loss of motivation.
Conclusions
These findings demonstrate that mAMPH exposure and withdrawal lead to steeper discounting of reward value by effort, an effect that is consistent with the effect of mAMPH on discounting by delay, and which may reflect an underlying shared mechanism.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28584929</pmid><doi>10.1007/s00213-017-4656-z</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Psychopharmacology, 2017-09, Vol.234 (18), p.2697-2705 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animal behavior Animals Biomedical and Life Sciences Biomedicine Central Nervous System Stimulants - pharmacology Choice Behavior - drug effects Choice Behavior - physiology Complications and side effects Delay Discounting - drug effects Delay Discounting - physiology Drug abuse Drug addiction Drug interactions Drug withdrawal Experiments Male Males Methamphetamine Methamphetamine - pharmacology Motivation Motivation - drug effects Motivation - physiology Neurosciences Observations Original Investigation Pellets Pharmacology/Toxicology Psychiatry Psychopharmacology Rats Rats, Long-Evans Reinforcement Reward Rodents Sensitivity Substance Withdrawal Syndrome - psychology Sucrose Sugar Time Factors Withdrawal |
| title | Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats |
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