Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis

Targeted therapies for lung adenocarcinoma (LUAD) have improved patient outcomes; however, drug resistance remains a major problem. One strategy to achieve durable response is to develop combination-based therapies that target both mutated oncogenes and key modifiers of oncogene-driven tumorigenesis...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of thoracic oncology 2019-04, Vol.14 (4), p.656-671
Hauptverfasser:	O’Farrell, Hannah, Harbourne, Bryant, Kurlawala, Zimple, Inoue, Yusuke, Nagelberg, Amy L., Martinez, Victor D., Lu, Daniel, Oh, Min Hee, Coe, Bradley P., Thu, Kelsie L., Somwar, Romel, Lam, Stephen, Lam, Wan L., Unni, Arun M., Beverly, Levi, Lockwood, William W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Animals Carcinogenesis Cell Line, Tumor Chromosome Deletion EGFR ErbB Receptors - genetics ErbB Receptors - metabolism Gene Amplification Genomics HEK293 Cells HeLa Cells Humans Integrative genomics Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Mutation Oncogenes Signal Transduction Signaling Targeted therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!