Transcriptional profiles reveal a stepwise developmental program of memory CD8+ T cell differentiation
Highlights • We perform whole transcriptome analysis of distinct CD8+ T-cell memory populations arising endogenously following immunization with clinical and pre-clinical vaccines regimens. • We find that transcriptional proximity relationships between endogenous TN , TCM , TEM and TEFF place memory...
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| Veröffentlicht in: | Vaccine 2015-02, Vol.33 (7), p.914-923 |
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| container_title | Vaccine |
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| creator | Roychoudhuri, Rahul Lefebvre, Francois Honda, Mitsuo Pan, Li Ji, Yun Klebanoff, Christopher A Nichols, Carmen N Fourati, Slim Hegazy, Ahmed N Goulet, Jean-Philippe Gattinoni, Luca Nabel, Gary J Gilliet, Michel Cameron, Mark Restifo, Nicholas P Sékaly, Rafick P Flatz, Lukas |
| description | Highlights • We perform whole transcriptome analysis of distinct CD8+ T-cell memory populations arising endogenously following immunization with clinical and pre-clinical vaccines regimens. • We find that transcriptional proximity relationships between endogenous TN , TCM , TEM and TEFF place memory cells at an intermediate state of differentiation between TN and TEFF. • We compare transcriptional differences between TN , TCM , TEM and TEFF cells with known changes when CD8+ T cells undergo repeated antigen stimulation. • We find that at a single time-point following vaccination, cells can be found with the transcriptional imprint of distinct exposures to antigen. • Our analysis favors the progressive differentiation model whereby cumulative antigen stimulation drives differentiation specifically from TN > TCM > TEM > TEFF. |
| doi_str_mv | 10.1016/j.vaccine.2014.10.007 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 11, 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-2cfcad7d4eb230a2ffa954c5ae6e379530827087f25360af93e37eef37db8b613</citedby><cites>FETCH-LOGICAL-c653t-2cfcad7d4eb230a2ffa954c5ae6e379530827087f25360af93e37eef37db8b613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1721669224?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25446821$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roychoudhuri, Rahul</creatorcontrib><creatorcontrib>Lefebvre, Francois</creatorcontrib><creatorcontrib>Honda, Mitsuo</creatorcontrib><creatorcontrib>Pan, Li</creatorcontrib><creatorcontrib>Ji, Yun</creatorcontrib><creatorcontrib>Klebanoff, Christopher A</creatorcontrib><creatorcontrib>Nichols, Carmen N</creatorcontrib><creatorcontrib>Fourati, Slim</creatorcontrib><creatorcontrib>Hegazy, Ahmed N</creatorcontrib><creatorcontrib>Goulet, Jean-Philippe</creatorcontrib><creatorcontrib>Gattinoni, Luca</creatorcontrib><creatorcontrib>Nabel, Gary J</creatorcontrib><creatorcontrib>Gilliet, Michel</creatorcontrib><creatorcontrib>Cameron, Mark</creatorcontrib><creatorcontrib>Restifo, Nicholas P</creatorcontrib><creatorcontrib>Sékaly, Rafick P</creatorcontrib><creatorcontrib>Flatz, Lukas</creatorcontrib><title>Transcriptional profiles reveal a stepwise developmental program of memory CD8+ T cell differentiation</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • We perform whole transcriptome analysis of distinct CD8+ T-cell memory populations arising endogenously following immunization with clinical and pre-clinical vaccines regimens. • We find that transcriptional proximity relationships between endogenous TN , TCM , TEM and TEFF place memory cells at an intermediate state of differentiation between TN and TEFF. • We compare transcriptional differences between TN , TCM , TEM and TEFF cells with known changes when CD8+ T cells undergo repeated antigen stimulation. • We find that at a single time-point following vaccination, cells can be found with the transcriptional imprint of distinct exposures to antigen. • Our analysis favors the progressive differentiation model whereby cumulative antigen stimulation drives differentiation specifically from TN > TCM > TEM > TEFF.</description><subject>Adenovirus vector</subject><subject>Adenoviruses</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antigens</subject><subject>CD8</subject><subject>CD8-Positive T-Lymphocytes - cytology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - physiology</subject><subject>Cells, Cultured</subject><subject>Experiments</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Gene expression</subject><subject>Hypotheses</subject><subject>Immunization</subject><subject>Immunologic Memory - immunology</subject><subject>Immunologic Memory - physiology</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>LCMV vector</subject><subject>Lymphocytes</subject><subject>Memory T cells</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Prime-boost vaccination</subject><subject>T cell memory</subject><subject>T cell receptors</subject><subject>Vaccines</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk2P0zAQhi0EYsvCTwBZ4oKEUvzt5LIIlU9pJQ4UaW-W64wXlyTO2mlR_z2OWhbYC5wsj595PTPvIPSUkiUlVL3aLvfWuTDAkhEqSmxJiL6HFrTWvGKS1vfRgjAlKkHJ1Rl6lPOWECI5bR6iMyaFUDWjC-TXyQ7ZpTBOIQ62w2OKPnSQcYI9lLvFeYLxR8iA2xLp4tjDMB3B62R7HD3uoY_pgFdv65d4jR10HW6D95AKGews_Bg98LbL8OR0nqOv79-tVx-ry88fPq3eXFZOST5VzHlnW90K2DBOLPPeNlI4aUEB143kpGaa1NozyRWxvuElDOC5bjf1RlF-ji6OuuNu00PrSgHJdmZMobfpYKIN5u-XIXwz13FvlOCNUE0ReHESSPFmB3kyfchzR3aAuMuGKkUEFZKo_0AlE7Sh9Yw-v4Nu4y6VcRdKs6LZMCYKJY-USzHnBP62bkrMbLrZmpPpZjZ9DhfTS96zP5u-zfrlcgFeHwEoo98HSCa7AIODNiRwk2lj-OcXF3cUXBeG4Gz3HQ6Qf3djMjPEfJk3b148KgjlSl_xn44Y1uA</recordid><startdate>20150211</startdate><enddate>20150211</enddate><creator>Roychoudhuri, Rahul</creator><creator>Lefebvre, Francois</creator><creator>Honda, Mitsuo</creator><creator>Pan, Li</creator><creator>Ji, Yun</creator><creator>Klebanoff, Christopher A</creator><creator>Nichols, Carmen N</creator><creator>Fourati, Slim</creator><creator>Hegazy, Ahmed N</creator><creator>Goulet, Jean-Philippe</creator><creator>Gattinoni, Luca</creator><creator>Nabel, Gary J</creator><creator>Gilliet, Michel</creator><creator>Cameron, Mark</creator><creator>Restifo, Nicholas P</creator><creator>Sékaly, Rafick P</creator><creator>Flatz, Lukas</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150211</creationdate><title>Transcriptional profiles reveal a stepwise developmental program of memory CD8+ T cell differentiation</title><author>Roychoudhuri, Rahul ; Lefebvre, Francois ; Honda, Mitsuo ; Pan, Li ; Ji, Yun ; Klebanoff, Christopher A ; Nichols, Carmen N ; Fourati, Slim ; Hegazy, Ahmed N ; Goulet, Jean-Philippe ; Gattinoni, Luca ; Nabel, Gary J ; Gilliet, Michel ; Cameron, Mark ; Restifo, Nicholas P ; Sékaly, Rafick P ; Flatz, Lukas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-2cfcad7d4eb230a2ffa954c5ae6e379530827087f25360af93e37eef37db8b613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenovirus vector</topic><topic>Adenoviruses</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antigens</topic><topic>CD8</topic><topic>CD8-Positive T-Lymphocytes - cytology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - metabolism</topic><topic>Cell differentiation</topic><topic>Cell Differentiation - physiology</topic><topic>Cells, Cultured</topic><topic>Experiments</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Gene expression</topic><topic>Hypotheses</topic><topic>Immunization</topic><topic>Immunologic Memory - immunology</topic><topic>Immunologic Memory - physiology</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>LCMV vector</topic><topic>Lymphocytes</topic><topic>Memory T cells</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Prime-boost vaccination</topic><topic>T cell memory</topic><topic>T cell receptors</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roychoudhuri, Rahul</creatorcontrib><creatorcontrib>Lefebvre, Francois</creatorcontrib><creatorcontrib>Honda, Mitsuo</creatorcontrib><creatorcontrib>Pan, Li</creatorcontrib><creatorcontrib>Ji, Yun</creatorcontrib><creatorcontrib>Klebanoff, Christopher A</creatorcontrib><creatorcontrib>Nichols, Carmen N</creatorcontrib><creatorcontrib>Fourati, Slim</creatorcontrib><creatorcontrib>Hegazy, Ahmed N</creatorcontrib><creatorcontrib>Goulet, Jean-Philippe</creatorcontrib><creatorcontrib>Gattinoni, Luca</creatorcontrib><creatorcontrib>Nabel, Gary J</creatorcontrib><creatorcontrib>Gilliet, Michel</creatorcontrib><creatorcontrib>Cameron, Mark</creatorcontrib><creatorcontrib>Restifo, Nicholas P</creatorcontrib><creatorcontrib>Sékaly, Rafick P</creatorcontrib><creatorcontrib>Flatz, Lukas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - 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| ispartof | Vaccine, 2015-02, Vol.33 (7), p.914-923 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Adenovirus vector Adenoviruses Allergy and Immunology Animals Antigens CD8 CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell differentiation Cell Differentiation - physiology Cells, Cultured Experiments Female Flow Cytometry Gene expression Hypotheses Immunization Immunologic Memory - immunology Immunologic Memory - physiology Infections Infectious diseases LCMV vector Lymphocytes Memory T cells Mice Mice, Inbred BALB C Oligonucleotide Array Sequence Analysis Prime-boost vaccination T cell memory T cell receptors Vaccines |
| title | Transcriptional profiles reveal a stepwise developmental program of memory CD8+ T cell differentiation |
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