Severe midaortic syndrome: a stepwise approach to treatment with drug-eluting balloons: a case report
Abstract Background Severe forms of the midaortic syndrome cause persistent arterial hypertension and can lead to angina abdominalis. Untreated, morbidity, and mortality are significant. In addition to palliation through bypass surgery, few other therapeutic approaches lead to a long-term relief. Dr...
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| Veröffentlicht in: | European heart journal : case reports 2019-03, Vol.3 (1), p.ytz017 |
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| container_title | European heart journal : case reports |
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| creator | Zartner, Peter Hart, Christopher Schneider, Martin B E |
| description | Abstract
Background
Severe forms of the midaortic syndrome cause persistent arterial hypertension and can lead to angina abdominalis. Untreated, morbidity, and mortality are significant. In addition to palliation through bypass surgery, few other therapeutic approaches lead to a long-term relief. Drug-eluting balloons (DEB) covered with paclitaxel, a cytostatic drug, have proven to be effective in bifurcational lesions and for in-stent stenoses in coronary arteries.
Case summary
In a 15-year-old girl with severe midaortic syndrome and multiple collateral arteries, four interventional balloon dilatations with DEB of increasing diameters resolved the stenosis within 8 months. After a procedure free interval of now 2.7 years, the anatomical and the physical condition of the patient remained unchanged.
Discussion
This stepwise approach, with a low procedural risk and a lasting result may justify further investigations into this combined treatment. |
| doi_str_mv | 10.1093/ehjcr/ytz017 |
| format | Article |
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Background
Severe forms of the midaortic syndrome cause persistent arterial hypertension and can lead to angina abdominalis. Untreated, morbidity, and mortality are significant. In addition to palliation through bypass surgery, few other therapeutic approaches lead to a long-term relief. Drug-eluting balloons (DEB) covered with paclitaxel, a cytostatic drug, have proven to be effective in bifurcational lesions and for in-stent stenoses in coronary arteries.
Case summary
In a 15-year-old girl with severe midaortic syndrome and multiple collateral arteries, four interventional balloon dilatations with DEB of increasing diameters resolved the stenosis within 8 months. After a procedure free interval of now 2.7 years, the anatomical and the physical condition of the patient remained unchanged.
Discussion
This stepwise approach, with a low procedural risk and a lasting result may justify further investigations into this combined treatment.</description><identifier>ISSN: 2514-2119</identifier><identifier>EISSN: 2514-2119</identifier><identifier>DOI: 10.1093/ehjcr/ytz017</identifier><identifier>PMID: 31020259</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Angina pectoris ; Arteries ; Care and treatment ; Case Reports ; Complications and side effects ; Congenital heart defects ; Coronary artery bypass ; Diseases ; Drug-eluting stents ; Everolimus ; Genetic disorders ; Heart diseases ; Hypertension ; Morbidity ; Mortality ; Stenosis ; Stents ; Surgery ; Teenage girls</subject><ispartof>European heart journal : case reports, 2019-03, Vol.3 (1), p.ytz017</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. 2019</rights><rights>COPYRIGHT 2019 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-c91c98a5c297ef03ee683cabd4974d962b7239154f677b9e8311666b1bcba63c3</citedby><cites>FETCH-LOGICAL-c450t-c91c98a5c297ef03ee683cabd4974d962b7239154f677b9e8311666b1bcba63c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439396/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439396/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31020259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zartner, Peter</creatorcontrib><creatorcontrib>Hart, Christopher</creatorcontrib><creatorcontrib>Schneider, Martin B E</creatorcontrib><title>Severe midaortic syndrome: a stepwise approach to treatment with drug-eluting balloons: a case report</title><title>European heart journal : case reports</title><addtitle>Eur Heart J Case Rep</addtitle><description>Abstract
Background
Severe forms of the midaortic syndrome cause persistent arterial hypertension and can lead to angina abdominalis. Untreated, morbidity, and mortality are significant. In addition to palliation through bypass surgery, few other therapeutic approaches lead to a long-term relief. Drug-eluting balloons (DEB) covered with paclitaxel, a cytostatic drug, have proven to be effective in bifurcational lesions and for in-stent stenoses in coronary arteries.
Case summary
In a 15-year-old girl with severe midaortic syndrome and multiple collateral arteries, four interventional balloon dilatations with DEB of increasing diameters resolved the stenosis within 8 months. After a procedure free interval of now 2.7 years, the anatomical and the physical condition of the patient remained unchanged.
Discussion
This stepwise approach, with a low procedural risk and a lasting result may justify further investigations into this combined treatment.</description><subject>Angina pectoris</subject><subject>Arteries</subject><subject>Care and treatment</subject><subject>Case Reports</subject><subject>Complications and side effects</subject><subject>Congenital heart defects</subject><subject>Coronary artery bypass</subject><subject>Diseases</subject><subject>Drug-eluting stents</subject><subject>Everolimus</subject><subject>Genetic disorders</subject><subject>Heart diseases</subject><subject>Hypertension</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Stenosis</subject><subject>Stents</subject><subject>Surgery</subject><subject>Teenage girls</subject><issn>2514-2119</issn><issn>2514-2119</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kc9LBCEUxyWKitpb5xA6dGlKxxldOwQR_YKgQ3UWx3mza8yMg7rF9tdnTS0FER6ePj_fL0-_CO1RckyJZCcwfzb-ZBnfCBVraDsvaZHllMr1H_stNAnhmRCSEya5YJtoi9F0yEu5jeABXsAD7mytnY_W4LDsa-86OMUahwjDqw2A9TB4p80cR4ejBx076CN-tXGOa7-YZdAuou1nuNJt61wfPsRGJ6GHIdnuoo1GtwEmX3UHPV1dPl7cZHf317cX53eZKUoSMyOpkVNdmlwKaAgD4FNmdFUXUhS15HklciZpWTRciErClFHKOa9oZSrNmWE76Gz0HRZVB7VJQ3rdqsHbTvulctqq3ze9nauZe1G8YDJ9TjI4GA1mugVl-8YlzHQ2GHXOqRC0YFORqOM_qLRq6KxxPTQ29X8JjkaB8S4ED81qJErUR5DqM0g1Bpnw_Z_PWMHfsSXgcATcYvjf6h04-Knh</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Zartner, Peter</creator><creator>Hart, Christopher</creator><creator>Schneider, Martin B E</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20190301</creationdate><title>Severe midaortic syndrome: a stepwise approach to treatment with drug-eluting balloons: a case report</title><author>Zartner, Peter ; Hart, Christopher ; Schneider, Martin B E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-c91c98a5c297ef03ee683cabd4974d962b7239154f677b9e8311666b1bcba63c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angina pectoris</topic><topic>Arteries</topic><topic>Care and treatment</topic><topic>Case Reports</topic><topic>Complications and side effects</topic><topic>Congenital heart defects</topic><topic>Coronary artery bypass</topic><topic>Diseases</topic><topic>Drug-eluting stents</topic><topic>Everolimus</topic><topic>Genetic disorders</topic><topic>Heart diseases</topic><topic>Hypertension</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Stenosis</topic><topic>Stents</topic><topic>Surgery</topic><topic>Teenage girls</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zartner, Peter</creatorcontrib><creatorcontrib>Hart, Christopher</creatorcontrib><creatorcontrib>Schneider, Martin B E</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European heart journal : case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zartner, Peter</au><au>Hart, Christopher</au><au>Schneider, Martin B E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe midaortic syndrome: a stepwise approach to treatment with drug-eluting balloons: a case report</atitle><jtitle>European heart journal : case reports</jtitle><addtitle>Eur Heart J Case Rep</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>3</volume><issue>1</issue><spage>ytz017</spage><pages>ytz017-</pages><issn>2514-2119</issn><eissn>2514-2119</eissn><abstract>Abstract
Background
Severe forms of the midaortic syndrome cause persistent arterial hypertension and can lead to angina abdominalis. Untreated, morbidity, and mortality are significant. In addition to palliation through bypass surgery, few other therapeutic approaches lead to a long-term relief. Drug-eluting balloons (DEB) covered with paclitaxel, a cytostatic drug, have proven to be effective in bifurcational lesions and for in-stent stenoses in coronary arteries.
Case summary
In a 15-year-old girl with severe midaortic syndrome and multiple collateral arteries, four interventional balloon dilatations with DEB of increasing diameters resolved the stenosis within 8 months. After a procedure free interval of now 2.7 years, the anatomical and the physical condition of the patient remained unchanged.
Discussion
This stepwise approach, with a low procedural risk and a lasting result may justify further investigations into this combined treatment.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31020259</pmid><doi>10.1093/ehjcr/ytz017</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | European heart journal : case reports, 2019-03, Vol.3 (1), p.ytz017 |
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| language | eng |
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| source | Oxford Journals Open Access Collection; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Angina pectoris Arteries Care and treatment Case Reports Complications and side effects Congenital heart defects Coronary artery bypass Diseases Drug-eluting stents Everolimus Genetic disorders Heart diseases Hypertension Morbidity Mortality Stenosis Stents Surgery Teenage girls |
| title | Severe midaortic syndrome: a stepwise approach to treatment with drug-eluting balloons: a case report |
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