The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats
Metabolic surgery ameliorates insulin resistance and is associated with long-term, effective weight loss, but the mechanisms involved remain unknown. Here, the duodenal-jejunal omega switch (DJOS) surgery in combination with highfat, high-carbohydrate diet was performed on diet obese rats and joint...
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| creator | Stygar, Dominika Skrzep-Poloczek, Bronisława Romuk, Ewa Chełmecka, Elżbieta Poloczek, Jakub Sawczyn, Tomasz Maciarz, Justyna Kukla, Michał Karcz, Konrad W. Jochem, Jerzy |
| description | Metabolic surgery ameliorates insulin resistance and is associated with long-term, effective weight loss, but the mechanisms involved remain unknown. Here, the duodenal-jejunal omega switch (DJOS) surgery in combination with highfat, high-carbohydrate diet was performed on diet obese rats and joint effects of bariatric surgery and different dietary patterns on heat shock protein 70 (HSP70) and HSP90 plasma and liver concentrations were measured. We found that plasma and liver levels of HSP70 were lower after DJOS surgery in comparison to the control in the groups of animals kept on control diet (CD) and high-fat, high-sugar diet (HFS) but the postoperative change of the diet led to the increase in HSP70 in plasma and liver concentration in DJOS-operated animals. A high-calorie meal, rich in carbohydrates and fats, significantly increased circulating levels of HSP90, reducing the normalising effect of DJOS. The HFS diet applied during all stages of the experiment led to the higher levels of liver HSP90 concentration. The combination of CD and DJOS surgery was the most efficient in the lowering of the HSP90 liver concentration. The normalisation of circulating levels and liver concentrations of HSP70 and HSP90 may be achieved in a combination of DJOS procedure with a proper dietary plan. |
| doi_str_mv | 10.1007/s12192-019-00976-2 |
| format | Article |
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Here, the duodenal-jejunal omega switch (DJOS) surgery in combination with highfat, high-carbohydrate diet was performed on diet obese rats and joint effects of bariatric surgery and different dietary patterns on heat shock protein 70 (HSP70) and HSP90 plasma and liver concentrations were measured. We found that plasma and liver levels of HSP70 were lower after DJOS surgery in comparison to the control in the groups of animals kept on control diet (CD) and high-fat, high-sugar diet (HFS) but the postoperative change of the diet led to the increase in HSP70 in plasma and liver concentration in DJOS-operated animals. A high-calorie meal, rich in carbohydrates and fats, significantly increased circulating levels of HSP90, reducing the normalising effect of DJOS. The HFS diet applied during all stages of the experiment led to the higher levels of liver HSP90 concentration. The combination of CD and DJOS surgery was the most efficient in the lowering of the HSP90 liver concentration. The normalisation of circulating levels and liver concentrations of HSP70 and HSP90 may be achieved in a combination of DJOS procedure with a proper dietary plan.</description><identifier>ISSN: 1355-8145</identifier><identifier>EISSN: 1466-1268</identifier><identifier>DOI: 10.1007/s12192-019-00976-2</identifier><identifier>PMID: 30840227</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Animals ; Bariatric Surgery - methods ; Biochemistry ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; Body weight loss ; Cancer Research ; Carbohydrates ; Cell Biology ; Diet ; Diet, Carbohydrate Loading ; Diet, High-Fat ; Disease Models, Animal ; Fats ; Gastrointestinal surgery ; Heat shock proteins ; High carbohydrate diet ; High fat diet ; HSP70 Heat-Shock Proteins - blood ; Hsp70 protein ; HSP90 Heat-Shock Proteins - blood ; Hsp90 protein ; Immunology ; Insulin ; Insulin resistance ; Liver ; Liver - metabolism ; Male ; Neurosciences ; Obesity - diet therapy ; Obesity - surgery ; Original Paper ; Oxidative stress ; Plasma ; Rats ; Rats, Sprague-Dawley ; Rodents ; Sugar ; Surgery ; Weight loss</subject><ispartof>Cell stress & chaperones, 2019-03, Vol.24 (2), p.427-439</ispartof><rights>Cell Stress Society International 2019</rights><rights>The Author(s) 2019</rights><rights>Cell Stress and Chaperones is a copyright of Springer, (2019). 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Here, the duodenal-jejunal omega switch (DJOS) surgery in combination with highfat, high-carbohydrate diet was performed on diet obese rats and joint effects of bariatric surgery and different dietary patterns on heat shock protein 70 (HSP70) and HSP90 plasma and liver concentrations were measured. We found that plasma and liver levels of HSP70 were lower after DJOS surgery in comparison to the control in the groups of animals kept on control diet (CD) and high-fat, high-sugar diet (HFS) but the postoperative change of the diet led to the increase in HSP70 in plasma and liver concentration in DJOS-operated animals. A high-calorie meal, rich in carbohydrates and fats, significantly increased circulating levels of HSP90, reducing the normalising effect of DJOS. The HFS diet applied during all stages of the experiment led to the higher levels of liver HSP90 concentration. The combination of CD and DJOS surgery was the most efficient in the lowering of the HSP90 liver concentration. 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Here, the duodenal-jejunal omega switch (DJOS) surgery in combination with highfat, high-carbohydrate diet was performed on diet obese rats and joint effects of bariatric surgery and different dietary patterns on heat shock protein 70 (HSP70) and HSP90 plasma and liver concentrations were measured. We found that plasma and liver levels of HSP70 were lower after DJOS surgery in comparison to the control in the groups of animals kept on control diet (CD) and high-fat, high-sugar diet (HFS) but the postoperative change of the diet led to the increase in HSP70 in plasma and liver concentration in DJOS-operated animals. A high-calorie meal, rich in carbohydrates and fats, significantly increased circulating levels of HSP90, reducing the normalising effect of DJOS. The HFS diet applied during all stages of the experiment led to the higher levels of liver HSP90 concentration. The combination of CD and DJOS surgery was the most efficient in the lowering of the HSP90 liver concentration. 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| subjects | Animals Bariatric Surgery - methods Biochemistry Biomarkers - blood Biomedical and Life Sciences Biomedicine Body weight loss Cancer Research Carbohydrates Cell Biology Diet Diet, Carbohydrate Loading Diet, High-Fat Disease Models, Animal Fats Gastrointestinal surgery Heat shock proteins High carbohydrate diet High fat diet HSP70 Heat-Shock Proteins - blood Hsp70 protein HSP90 Heat-Shock Proteins - blood Hsp90 protein Immunology Insulin Insulin resistance Liver Liver - metabolism Male Neurosciences Obesity - diet therapy Obesity - surgery Original Paper Oxidative stress Plasma Rats Rats, Sprague-Dawley Rodents Sugar Surgery Weight loss |
| title | The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats |
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