Efficacy of MEK inhibition in patients with histiocytic neoplasms

Histiocytic neoplasms are a heterogeneous group of clonal haematopoietic disorders that are marked by diverse mutations in the mitogen-activated protein kinase (MAPK) pathway 1 , 2 . For the 50% of patients with histiocytosis who have BRAF V600 mutations 3 – 5 , RAF inhibition is highly efficacious...

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Veröffentlicht in:	Nature (London) 2019-03, Vol.567 (7749), p.521-524
Hauptverfasser:	Diamond, Eli L., Durham, Benjamin H., Ulaner, Gary A., Drill, Esther, Buthorn, Justin, Ki, Michelle, Bitner, Lillian, Cho, Hana, Young, Robert J., Francis, Jasmine H., Rampal, Raajit, Lacouture, Mario, Brody, Lynn A., Ozkaya, Neval, Dogan, Ahmet, Rosen, Neal, Iasonos, Alexia, Abdel-Wahab, Omar, Hyman, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 631/67/1059/602 631/67/68 692/308/153 96/106 96/109 Azetidines - pharmacology Azetidines - therapeutic use Cancer therapies Care and treatment Clinical trials Confidence intervals Dependence Effectiveness Extracellular signal-regulated kinase Genotypes Histiocytic Disorders, Malignant - drug therapy Histiocytic Disorders, Malignant - enzymology Histiocytic Disorders, Malignant - genetics Histiocytic Disorders, Malignant - pathology Histiocytosis Histiocytosis - drug therapy Histiocytosis - enzymology Histiocytosis - genetics Histiocytosis - pathology Humanities and Social Sciences Humans Kinase inhibitors Kinases Letter MAP kinase MAP Kinase Kinase 1 - antagonists & inhibitors MAP Kinase Kinase 2 - antagonists & inhibitors MAP Kinase Kinase 2 - genetics MAP Kinase Signaling System - drug effects Medical prognosis Melanoma Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors multidisciplinary Mutation Neoplasms NMR Nuclear magnetic resonance Patient outcomes Patients Physiological aspects Piperidines - pharmacology Piperidines - therapeutic use Progression-Free Survival Protein kinase Proteins Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins c-raf - genetics Raf protein Response rates Science Science (multidisciplinary) Signal transduction Survival analysis Therapy Tumors
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