Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives

Thiotetronate-containing natural products, including thiolactomycin, thiotetromycin, and thiotetroamide, are potent, broad-spectrum antibacterial compounds that target fatty acid synthesis in bacteria. Natural modifications at the C-5 dialkyl position in this molecular series result in pronounced bi...

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Veröffentlicht in:	Organic & biomolecular chemistry 2019-03, Vol.17 (13), p.3416-3423
Hauptverfasser:	Rothe, Marlene L, Li, Jie, Garibay, Ernesto, Moore, Bradley S, McKinnie, Shaun M K
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthranilate Synthase - metabolism Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Antibacterial materials Biological activity Biological Products - chemistry Biological Products - metabolism Biological Products - pharmacology Cancer Carboxylic acids Cytochrome Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Cytochromes P450 Derivatives Dose-Response Relationship, Drug E coli Enzymes Escherichia coli - drug effects Fatty acids Hydroxylase Hydroxylation Inhibitors Methyltransferase Microbial Sensitivity Tests Molecular Structure N-Methyltransferase Natural products Nicotinamide Nicotinamide N-methyltransferase Nitrogenous Group Transferases - metabolism Oxidation Structure-Activity Relationship Substrates Synthesis Thiolactomycin Thiophenes - chemistry Thiophenes - metabolism Thiophenes - pharmacology Tuberculosis
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