Epithelial cell-derived cytokines: more than just signaling the alarm

The epithelial cell-derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 are central regulators of type 2 immunity, which drives a broad array of allergic responses. Often characterized as "alarmins" that are released by the barrier epithelium in response to external ins...

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Veröffentlicht in:	The Journal of clinical investigation 2019-04, Vol.129 (4), p.1441-1451
Hauptverfasser:	Roan, Florence, Obata-Ninomiya, Kazushige, Ziegler, Steven F
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy Animals Antibodies Asthma Biomedical research Blocking antibodies Cytokines Cytokines - immunology Dendritic cells Dermatitis Disease Epithelial cells Epithelial Cells - immunology Epithelial Cells - pathology Epithelium Food allergies Gastrointestinal system Growth factors Helper cells Humans Hypersensitivity Hypersensitivity - immunology Hypersensitivity - pathology Immune response Immunity, Innate Immunological memory Inflammation Lungs Lymphocytes Lymphocytes - immunology Lymphocytes - pathology Lymphocytes T Lymphoid cells Regulation Review Series Skin Thymic stromal lymphopoietin Thymus Transcription factors Websites
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