Cooperativity of E‐prostanoid receptor subtypes in regulating signaling and growth inhibition in human airway smooth muscle

ABSTRACTProstaglandin E2 (PGE2) is produced in the airway during allergic lung inflammation and both promotes and inhibits features of asthma pathology. These mixed effects relate to 4 E‐prostanoid (EP) receptor subtypes (EP1, 2, 3 and 4) expressed at different levels on different resident and infil...

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Veröffentlicht in:	The FASEB journal 2019-04, Vol.33 (4), p.4780-4789
Hauptverfasser:	Michael, James V., Gavrila, Adelina, Nayak, Ajay P., Pera, Tonio, Liberato, Jennifer R., Polischak, Steven R., Shah, Sushrut D., Deshpande, Deepak A., Penn, Raymond B.
Format:	Artikel
Sprache:	eng
Schlagworte:	airway remodeling asthma Calcium - metabolism Cyclic AMP - metabolism EP receptor HEK293 Cells Humans Immunoblotting Microscopy, Confocal Muscle, Smooth - metabolism prostaglandin Receptors, Prostaglandin E, EP2 Subtype - genetics Receptors, Prostaglandin E, EP2 Subtype - metabolism Receptors, Prostaglandin E, EP3 Subtype - genetics Receptors, Prostaglandin E, EP3 Subtype - metabolism Receptors, Prostaglandin E, EP4 Subtype - genetics Receptors, Prostaglandin E, EP4 Subtype - metabolism RNA, Small Interfering - genetics Signal Transduction - physiology
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