The short‐term efficacy of combined treatments targeting B cell and plasma cell in severe and refractory Anti‐N‐methyl‐D‐aspartate receptor encephalitis: Two case reports
Dear Editor, Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis, which is the most common type of autoimmune encephalitis, usually manifests as a clinical spectrum including psychiatric symptoms, cognitive disorders, epilepsy, and decreased levels of consciousness, autonomic dysfunction wi...
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| Veröffentlicht in: | CNS neuroscience & therapeutics 2019-01, Vol.25 (1), p.151-153 |
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| creator | Zhang, Xiao‐Ting Wang, Chun‐Juan Wang, Bao‐Jie Guo, Shou‐Gang |
| description | Dear Editor, Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis, which is the most common type of autoimmune encephalitis, usually manifests as a clinical spectrum including psychiatric symptoms, cognitive disorders, epilepsy, and decreased levels of consciousness, autonomic dysfunction with or without teratoma. When prednisone was reduced to 10 mg, she relapsed with a rapidly progressive personality disorder, emotional lability, hallucinations, irritability, seizure, and cognitive impairment and visited our hospital. Preliminary data suggested that the protracted clinical course of anti-NMDAR encephalitis is due to antibody production by long-lived plasma cells. |
| doi_str_mv | 10.1111/cns.13078 |
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When prednisone was reduced to 10 mg, she relapsed with a rapidly progressive personality disorder, emotional lability, hallucinations, irritability, seizure, and cognitive impairment and visited our hospital. Preliminary data suggested that the protracted clinical course of anti-NMDAR encephalitis is due to antibody production by long-lived plasma cells.</description><identifier>ISSN: 1755-5930</identifier><identifier>EISSN: 1755-5949</identifier><identifier>DOI: 10.1111/cns.13078</identifier><identifier>PMID: 30345626</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Anti-N-Methyl-D-Aspartate Receptor Encephalitis - blood ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - drug therapy ; B-Lymphocytes - drug effects ; Bortezomib - therapeutic use ; Case reports ; Drug Therapy, Combination ; Encephalitis ; Female ; Hematologic Agents - therapeutic use ; Humans ; Letter to the Editor ; Letters to the Editor ; Lymphocytes B ; Middle Aged ; Retreatment ; Seizures ; Young Adult</subject><ispartof>CNS neuroscience & therapeutics, 2019-01, Vol.25 (1), p.151-153</ispartof><rights>2018 John Wiley & Sons Ltd</rights><rights>2019. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). 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When prednisone was reduced to 10 mg, she relapsed with a rapidly progressive personality disorder, emotional lability, hallucinations, irritability, seizure, and cognitive impairment and visited our hospital. 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Wang, Chun‐Juan ; Wang, Bao‐Jie ; Guo, Shou‐Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4388-933e57bd7c29c122a216a14f60dbbebf6da1fedb71726d49b42bc2adacbff0de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anti-N-Methyl-D-Aspartate Receptor Encephalitis - blood</topic><topic>Anti-N-Methyl-D-Aspartate Receptor Encephalitis - drug therapy</topic><topic>B-Lymphocytes - drug effects</topic><topic>Bortezomib - therapeutic use</topic><topic>Case reports</topic><topic>Drug Therapy, Combination</topic><topic>Encephalitis</topic><topic>Female</topic><topic>Hematologic Agents - therapeutic use</topic><topic>Humans</topic><topic>Letter to the Editor</topic><topic>Letters to the Editor</topic><topic>Lymphocytes B</topic><topic>Middle Aged</topic><topic>Retreatment</topic><topic>Seizures</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiao‐Ting</creatorcontrib><creatorcontrib>Wang, Chun‐Juan</creatorcontrib><creatorcontrib>Wang, Bao‐Jie</creatorcontrib><creatorcontrib>Guo, Shou‐Gang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>CNS neuroscience & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Zhang, Xiao‐Ting</au><au>Wang, Chun‐Juan</au><au>Wang, Bao‐Jie</au><au>Guo, Shou‐Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The short‐term efficacy of combined treatments targeting B cell and plasma cell in severe and refractory Anti‐N‐methyl‐D‐aspartate receptor encephalitis: Two case reports</atitle><jtitle>CNS neuroscience & therapeutics</jtitle><addtitle>CNS Neurosci Ther</addtitle><date>2019-01</date><risdate>2019</risdate><volume>25</volume><issue>1</issue><spage>151</spage><epage>153</epage><pages>151-153</pages><issn>1755-5930</issn><eissn>1755-5949</eissn><abstract>Dear Editor, Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis, which is the most common type of autoimmune encephalitis, usually manifests as a clinical spectrum including psychiatric symptoms, cognitive disorders, epilepsy, and decreased levels of consciousness, autonomic dysfunction with or without teratoma. When prednisone was reduced to 10 mg, she relapsed with a rapidly progressive personality disorder, emotional lability, hallucinations, irritability, seizure, and cognitive impairment and visited our hospital. Preliminary data suggested that the protracted clinical course of anti-NMDAR encephalitis is due to antibody production by long-lived plasma cells.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>30345626</pmid><doi>10.1111/cns.13078</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0003-3821-3602</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-N-Methyl-D-Aspartate Receptor Encephalitis - blood Anti-N-Methyl-D-Aspartate Receptor Encephalitis - drug therapy B-Lymphocytes - drug effects Bortezomib - therapeutic use Case reports Drug Therapy, Combination Encephalitis Female Hematologic Agents - therapeutic use Humans Letter to the Editor Letters to the Editor Lymphocytes B Middle Aged Retreatment Seizures Young Adult |
| title | The short‐term efficacy of combined treatments targeting B cell and plasma cell in severe and refractory Anti‐N‐methyl‐D‐aspartate receptor encephalitis: Two case reports |
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