The CARMA3-Bcl10-MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor-Positive Breast Cancer

The angiotensin II receptor AGTR1, which mediates vasoconstrictive and inflammatory signaling in vascular disease, is overexpressed aberrantly in some breast cancers. In this study, we established the significance of an AGTR1-responsive NFκB signaling pathway in this breast cancer subset. We documen...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-03, Vol.78 (5), p.1225-1240
Hauptverfasser:	Ekambaram, Prasanna, Lee, Jia-Ying Lloyd, Hubel, Nathaniel E, Hu, Dong, Yerneni, Saigopalakrishna, Campbell, Phil G, Pollock, Netanya, Klei, Linda R, Concel, Vincent J, Delekta, Phillip C, Chinnaiyan, Arul M, Tomlins, Scott A, Rhodes, Daniel R, Priedigkeit, Nolan, Lee, Adrian V, Oesterreich, Steffi, McAllister-Lucas, Linda M, Lucas, Peter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Angiogenesis Angiotensin Angiotensin II Animals Apoptosis B-Cell CLL-Lymphoma 10 Protein - antagonists & inhibitors B-Cell CLL-Lymphoma 10 Protein - genetics B-Cell CLL-Lymphoma 10 Protein - metabolism Bcl-10 protein Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer therapies CARD Signaling Adaptor Proteins - antagonists & inhibitors CARD Signaling Adaptor Proteins - genetics CARD Signaling Adaptor Proteins - metabolism Cell Movement Cell Proliferation Chick Embryo Endothelial cells ErbB-2 protein Female Follow-Up Studies Gene Expression Regulation, Neoplastic Humans Ligands Lymph nodes Metastases Mice Mice, Nude Migration Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein - antagonists & inhibitors Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein - genetics Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein - metabolism Neovascularization, Pathologic NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Prognosis Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Receptors, Angiotensin - chemistry Receptors, Angiotensin - genetics Receptors, Angiotensin - metabolism RNA, Small Interfering - genetics Signal transduction Survival Rate Tumor Cells, Cultured Vascular diseases Xenograft Model Antitumor Assays
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