Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates

Faithful DNA replication is challenged by stalling of replication forks during S phase. Replication stress is further increased in cancer cells or in response to genotoxic insults. Using live single-cell image analysis, we found that CDK2 activity fluctuates throughout an unperturbed S phase. We sho...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell systems 2018-07, Vol.7 (1), p.17-27.e3
Hauptverfasser:	Daigh, Leighton H., Liu, Chad, Chung, Mingyu, Cimprich, Karlene A., Meyer, Tobias
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - metabolism ATR Cdk2 activity reporter Cell Cycle - physiology Cell Cycle Proteins - genetics Cell Division Cell Line Cyclin-Dependent Kinase 2 - metabolism Cyclin-Dependent Kinase 2 - physiology Cyclin-Dependent Kinases - genetics DNA - biosynthesis DNA Damage DNA Replication DNA-Binding Proteins - genetics Humans live-cell-cycle analysis MCF-7 Cells replication stress S Phase - physiology Single-Cell Analysis - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!